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Cutting Edge: β-Catenin Is Dispensable for T Cell Effector Differentiation, Memory Formation, and Recall Responses
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| Zeitschriftentitel: | The Journal of Immunology |
|---|---|
| Personen und Körperschaften: | , |
| In: | The Journal of Immunology, 187, 2011, 4, S. 1542-1546 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
The American Association of Immunologists
|
| Schlagwörter: |
| author_facet |
Prlic, Martin Bevan, Michael J. Prlic, Martin Bevan, Michael J. |
|---|---|
| author |
Prlic, Martin Bevan, Michael J. |
| spellingShingle |
Prlic, Martin Bevan, Michael J. The Journal of Immunology Cutting Edge: β-Catenin Is Dispensable for T Cell Effector Differentiation, Memory Formation, and Recall Responses Immunology Immunology and Allergy |
| author_sort |
prlic, martin |
| spelling |
Prlic, Martin Bevan, Michael J. 0022-1767 1550-6606 The American Association of Immunologists Immunology Immunology and Allergy http://dx.doi.org/10.4049/jimmunol.1100907 <jats:title>Abstract</jats:title> <jats:p>The molecular mechanisms that regulate mature T cell fate and enable cells to differentiate into memory T cells are largely unknown. Memory T cells share certain key features with stem cells: they both have the ability to self-renew and are long-lived. The Wnt–β-catenin signaling pathway is a key player in regulating stem cell self-renewal and differentiation. We generated a conditional knockout mouse that specifically lacks β-catenin in mature T cells and report in this article that β-catenin is not involved in regulating effector versus memory T cell differentiation. β-catenin–deficient memory T cells were phenotypically and functionally indistinguishable from control cells and made normal recall responses. β-catenin deficiency does not affect T cell migration, T cell function in a model of chronic infection, or lymphopenia-induced proliferation. Together, our data suggest that self-renewal and differentiation are regulated differently in memory T cells compared with epithelial and hematopoietic stem cells.</jats:p> Cutting Edge: β-Catenin Is Dispensable for T Cell Effector Differentiation, Memory Formation, and Recall Responses The Journal of Immunology |
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The American Association of Immunologists, 2011 |
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The American Association of Immunologists, 2011 |
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0022-1767 1550-6606 |
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The Journal of Immunology |
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| title |
Cutting Edge: β-Catenin Is Dispensable for T Cell Effector Differentiation, Memory Formation, and Recall Responses |
| title_unstemmed |
Cutting Edge: β-Catenin Is Dispensable for T Cell Effector Differentiation, Memory Formation, and Recall Responses |
| title_full |
Cutting Edge: β-Catenin Is Dispensable for T Cell Effector Differentiation, Memory Formation, and Recall Responses |
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Cutting Edge: β-Catenin Is Dispensable for T Cell Effector Differentiation, Memory Formation, and Recall Responses |
| title_full_unstemmed |
Cutting Edge: β-Catenin Is Dispensable for T Cell Effector Differentiation, Memory Formation, and Recall Responses |
| title_short |
Cutting Edge: β-Catenin Is Dispensable for T Cell Effector Differentiation, Memory Formation, and Recall Responses |
| title_sort |
cutting edge: β-catenin is dispensable for t cell effector differentiation, memory formation, and recall responses |
| topic |
Immunology Immunology and Allergy |
| url |
http://dx.doi.org/10.4049/jimmunol.1100907 |
| publishDate |
2011 |
| physical |
1542-1546 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>The molecular mechanisms that regulate mature T cell fate and enable cells to differentiate into memory T cells are largely unknown. Memory T cells share certain key features with stem cells: they both have the ability to self-renew and are long-lived. The Wnt–β-catenin signaling pathway is a key player in regulating stem cell self-renewal and differentiation. We generated a conditional knockout mouse that specifically lacks β-catenin in mature T cells and report in this article that β-catenin is not involved in regulating effector versus memory T cell differentiation. β-catenin–deficient memory T cells were phenotypically and functionally indistinguishable from control cells and made normal recall responses. β-catenin deficiency does not affect T cell migration, T cell function in a model of chronic infection, or lymphopenia-induced proliferation. Together, our data suggest that self-renewal and differentiation are regulated differently in memory T cells compared with epithelial and hematopoietic stem cells.</jats:p> |
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| author | Prlic, Martin, Bevan, Michael J. |
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| description | <jats:title>Abstract</jats:title> <jats:p>The molecular mechanisms that regulate mature T cell fate and enable cells to differentiate into memory T cells are largely unknown. Memory T cells share certain key features with stem cells: they both have the ability to self-renew and are long-lived. The Wnt–β-catenin signaling pathway is a key player in regulating stem cell self-renewal and differentiation. We generated a conditional knockout mouse that specifically lacks β-catenin in mature T cells and report in this article that β-catenin is not involved in regulating effector versus memory T cell differentiation. β-catenin–deficient memory T cells were phenotypically and functionally indistinguishable from control cells and made normal recall responses. β-catenin deficiency does not affect T cell migration, T cell function in a model of chronic infection, or lymphopenia-induced proliferation. Together, our data suggest that self-renewal and differentiation are regulated differently in memory T cells compared with epithelial and hematopoietic stem cells.</jats:p> |
| doi_str_mv | 10.4049/jimmunol.1100907 |
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| imprint | The American Association of Immunologists, 2011 |
| imprint_str_mv | The American Association of Immunologists, 2011 |
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| physical | 1542-1546 |
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| spelling | Prlic, Martin Bevan, Michael J. 0022-1767 1550-6606 The American Association of Immunologists Immunology Immunology and Allergy http://dx.doi.org/10.4049/jimmunol.1100907 <jats:title>Abstract</jats:title> <jats:p>The molecular mechanisms that regulate mature T cell fate and enable cells to differentiate into memory T cells are largely unknown. Memory T cells share certain key features with stem cells: they both have the ability to self-renew and are long-lived. The Wnt–β-catenin signaling pathway is a key player in regulating stem cell self-renewal and differentiation. We generated a conditional knockout mouse that specifically lacks β-catenin in mature T cells and report in this article that β-catenin is not involved in regulating effector versus memory T cell differentiation. β-catenin–deficient memory T cells were phenotypically and functionally indistinguishable from control cells and made normal recall responses. β-catenin deficiency does not affect T cell migration, T cell function in a model of chronic infection, or lymphopenia-induced proliferation. Together, our data suggest that self-renewal and differentiation are regulated differently in memory T cells compared with epithelial and hematopoietic stem cells.</jats:p> Cutting Edge: β-Catenin Is Dispensable for T Cell Effector Differentiation, Memory Formation, and Recall Responses The Journal of Immunology |
| spellingShingle | Prlic, Martin, Bevan, Michael J., The Journal of Immunology, Cutting Edge: β-Catenin Is Dispensable for T Cell Effector Differentiation, Memory Formation, and Recall Responses, Immunology, Immunology and Allergy |
| title | Cutting Edge: β-Catenin Is Dispensable for T Cell Effector Differentiation, Memory Formation, and Recall Responses |
| title_full | Cutting Edge: β-Catenin Is Dispensable for T Cell Effector Differentiation, Memory Formation, and Recall Responses |
| title_fullStr | Cutting Edge: β-Catenin Is Dispensable for T Cell Effector Differentiation, Memory Formation, and Recall Responses |
| title_full_unstemmed | Cutting Edge: β-Catenin Is Dispensable for T Cell Effector Differentiation, Memory Formation, and Recall Responses |
| title_short | Cutting Edge: β-Catenin Is Dispensable for T Cell Effector Differentiation, Memory Formation, and Recall Responses |
| title_sort | cutting edge: β-catenin is dispensable for t cell effector differentiation, memory formation, and recall responses |
| title_unstemmed | Cutting Edge: β-Catenin Is Dispensable for T Cell Effector Differentiation, Memory Formation, and Recall Responses |
| topic | Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.4049/jimmunol.1100907 |