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Cutting Edge: β-Catenin Is Dispensable for T Cell Effector Differentiation, Memory Formation, and Recall Responses
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| Zeitschriftentitel: | The Journal of Immunology |
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| Personen und Körperschaften: | , |
| In: | The Journal of Immunology, 187, 2011, 4, S. 1542-1546 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
The American Association of Immunologists
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| Schlagwörter: |
| Zusammenfassung: | <jats:title>Abstract</jats:title> <jats:p>The molecular mechanisms that regulate mature T cell fate and enable cells to differentiate into memory T cells are largely unknown. Memory T cells share certain key features with stem cells: they both have the ability to self-renew and are long-lived. The Wnt–β-catenin signaling pathway is a key player in regulating stem cell self-renewal and differentiation. We generated a conditional knockout mouse that specifically lacks β-catenin in mature T cells and report in this article that β-catenin is not involved in regulating effector versus memory T cell differentiation. β-catenin–deficient memory T cells were phenotypically and functionally indistinguishable from control cells and made normal recall responses. β-catenin deficiency does not affect T cell migration, T cell function in a model of chronic infection, or lymphopenia-induced proliferation. Together, our data suggest that self-renewal and differentiation are regulated differently in memory T cells compared with epithelial and hematopoietic stem cells.</jats:p> |
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| Umfang: | 1542-1546 |
| ISSN: |
0022-1767
1550-6606 |
| DOI: | 10.4049/jimmunol.1100907 |