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A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines
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| Zeitschriftentitel: | Beilstein Journal of Organic Chemistry |
|---|---|
| Personen und Körperschaften: | , |
| In: | Beilstein Journal of Organic Chemistry, 12, 2016, S. 1-4 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Beilstein Institut
|
| Schlagwörter: |
| author_facet |
Johnson, Tarn C Marsden, Stephen P Johnson, Tarn C Marsden, Stephen P |
|---|---|
| author |
Johnson, Tarn C Marsden, Stephen P |
| spellingShingle |
Johnson, Tarn C Marsden, Stephen P Beilstein Journal of Organic Chemistry A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines Organic Chemistry |
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johnson, tarn c |
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Johnson, Tarn C Marsden, Stephen P 1860-5397 Beilstein Institut Organic Chemistry http://dx.doi.org/10.3762/bjoc.12.1 <jats:p>A convenient, one-pot, two-component synthesis of 2-(1-amidoalkyl)pyridines is reported, based upon the substitution of suitably-activated pyridine <jats:italic>N</jats:italic>-oxides by azlactone nucleophiles, followed by decarboxylative azlactone ring-opening. The synthesis obviates the need for precious metal catalysts to achieve a formal enolate arylation reaction, and constitutes a formally ‘umpoled’ approach to this valuable class of bioactive structures.</jats:p> A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines Beilstein Journal of Organic Chemistry |
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| title |
A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines |
| title_unstemmed |
A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines |
| title_full |
A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines |
| title_fullStr |
A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines |
| title_full_unstemmed |
A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines |
| title_short |
A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines |
| title_sort |
a convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines |
| topic |
Organic Chemistry |
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http://dx.doi.org/10.3762/bjoc.12.1 |
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2016 |
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1-4 |
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<jats:p>A convenient, one-pot, two-component synthesis of 2-(1-amidoalkyl)pyridines is reported, based upon the substitution of suitably-activated pyridine <jats:italic>N</jats:italic>-oxides by azlactone nucleophiles, followed by decarboxylative azlactone ring-opening. The synthesis obviates the need for precious metal catalysts to achieve a formal enolate arylation reaction, and constitutes a formally ‘umpoled’ approach to this valuable class of bioactive structures.</jats:p> |
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| author | Johnson, Tarn C, Marsden, Stephen P |
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| description | <jats:p>A convenient, one-pot, two-component synthesis of 2-(1-amidoalkyl)pyridines is reported, based upon the substitution of suitably-activated pyridine <jats:italic>N</jats:italic>-oxides by azlactone nucleophiles, followed by decarboxylative azlactone ring-opening. The synthesis obviates the need for precious metal catalysts to achieve a formal enolate arylation reaction, and constitutes a formally ‘umpoled’ approach to this valuable class of bioactive structures.</jats:p> |
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| spelling | Johnson, Tarn C Marsden, Stephen P 1860-5397 Beilstein Institut Organic Chemistry http://dx.doi.org/10.3762/bjoc.12.1 <jats:p>A convenient, one-pot, two-component synthesis of 2-(1-amidoalkyl)pyridines is reported, based upon the substitution of suitably-activated pyridine <jats:italic>N</jats:italic>-oxides by azlactone nucleophiles, followed by decarboxylative azlactone ring-opening. The synthesis obviates the need for precious metal catalysts to achieve a formal enolate arylation reaction, and constitutes a formally ‘umpoled’ approach to this valuable class of bioactive structures.</jats:p> A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines Beilstein Journal of Organic Chemistry |
| spellingShingle | Johnson, Tarn C, Marsden, Stephen P, Beilstein Journal of Organic Chemistry, A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines, Organic Chemistry |
| title | A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines |
| title_full | A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines |
| title_fullStr | A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines |
| title_full_unstemmed | A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines |
| title_short | A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines |
| title_sort | a convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines |
| title_unstemmed | A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines |
| topic | Organic Chemistry |
| url | http://dx.doi.org/10.3762/bjoc.12.1 |