A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines

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Bibliographische Detailangaben
Zeitschriftentitel:	Beilstein Journal of Organic Chemistry
Personen und Körperschaften:	Johnson, Tarn C, Marsden, Stephen P
In:	Beilstein Journal of Organic Chemistry, 12, 2016, S. 1-4
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	Beilstein Institut
Schlagwörter:	Organic Chemistry

Details
Zusammenfassung:	<jats:p>A convenient, one-pot, two-component synthesis of 2-(1-amidoalkyl)pyridines is reported, based upon the substitution of suitably-activated pyridine <jats:italic>N</jats:italic>-oxides by azlactone nucleophiles, followed by decarboxylative azlactone ring-opening. The synthesis obviates the need for precious metal catalysts to achieve a formal enolate arylation reaction, and constitutes a formally ‘umpoled’ approach to this valuable class of bioactive structures.</jats:p>
Umfang:	1-4
ISSN:	1860-5397
DOI:	10.3762/bjoc.12.1