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RNA-Binding Proteins in Acute Leukemias
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| Zeitschriftentitel: | International Journal of Molecular Sciences |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | International Journal of Molecular Sciences, 21, 2020, 10, S. 3409 |
| Format: | E-Article |
| Sprache: | Englisch |
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MDPI AG
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Schuschel, Konstantin Helwig, Matthias Hüttelmaier, Stefan Heckl, Dirk Klusmann, Jan-Henning Hoell, Jessica I Schuschel, Konstantin Helwig, Matthias Hüttelmaier, Stefan Heckl, Dirk Klusmann, Jan-Henning Hoell, Jessica I |
|---|---|
| author |
Schuschel, Konstantin Helwig, Matthias Hüttelmaier, Stefan Heckl, Dirk Klusmann, Jan-Henning Hoell, Jessica I |
| spellingShingle |
Schuschel, Konstantin Helwig, Matthias Hüttelmaier, Stefan Heckl, Dirk Klusmann, Jan-Henning Hoell, Jessica I International Journal of Molecular Sciences RNA-Binding Proteins in Acute Leukemias Inorganic Chemistry Organic Chemistry Physical and Theoretical Chemistry Computer Science Applications Spectroscopy Molecular Biology General Medicine Catalysis |
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schuschel, konstantin |
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Schuschel, Konstantin Helwig, Matthias Hüttelmaier, Stefan Heckl, Dirk Klusmann, Jan-Henning Hoell, Jessica I 1422-0067 MDPI AG Inorganic Chemistry Organic Chemistry Physical and Theoretical Chemistry Computer Science Applications Spectroscopy Molecular Biology General Medicine Catalysis http://dx.doi.org/10.3390/ijms21103409 <jats:p>Acute leukemias are genetic diseases caused by translocations or mutations, which dysregulate hematopoiesis towards malignant transformation. However, the molecular mode of action is highly versatile and ranges from direct transcriptional to post-transcriptional control, which includes RNA-binding proteins (RBPs) as crucial regulators of cell fate. RBPs coordinate RNA dynamics, including subcellular localization, translational efficiency and metabolism, by binding to their target messenger RNAs (mRNAs), thereby controlling the expression of the encoded proteins. In view of the growing interest in these regulators, this review summarizes recent research regarding the most influential RBPs relevant in acute leukemias in particular. The reported RBPs, either dysregulated or as components of fusion proteins, are described with respect to their functional domains, the pathways they affect, and clinical aspects associated with their dysregulation or altered functions.</jats:p> RNA-Binding Proteins in Acute Leukemias International Journal of Molecular Sciences |
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| title |
RNA-Binding Proteins in Acute Leukemias |
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RNA-Binding Proteins in Acute Leukemias |
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RNA-Binding Proteins in Acute Leukemias |
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RNA-Binding Proteins in Acute Leukemias |
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RNA-Binding Proteins in Acute Leukemias |
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RNA-Binding Proteins in Acute Leukemias |
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rna-binding proteins in acute leukemias |
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Inorganic Chemistry Organic Chemistry Physical and Theoretical Chemistry Computer Science Applications Spectroscopy Molecular Biology General Medicine Catalysis |
| url |
http://dx.doi.org/10.3390/ijms21103409 |
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2020 |
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3409 |
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<jats:p>Acute leukemias are genetic diseases caused by translocations or mutations, which dysregulate hematopoiesis towards malignant transformation. However, the molecular mode of action is highly versatile and ranges from direct transcriptional to post-transcriptional control, which includes RNA-binding proteins (RBPs) as crucial regulators of cell fate. RBPs coordinate RNA dynamics, including subcellular localization, translational efficiency and metabolism, by binding to their target messenger RNAs (mRNAs), thereby controlling the expression of the encoded proteins. In view of the growing interest in these regulators, this review summarizes recent research regarding the most influential RBPs relevant in acute leukemias in particular. The reported RBPs, either dysregulated or as components of fusion proteins, are described with respect to their functional domains, the pathways they affect, and clinical aspects associated with their dysregulation or altered functions.</jats:p> |
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| author | Schuschel, Konstantin, Helwig, Matthias, Hüttelmaier, Stefan, Heckl, Dirk, Klusmann, Jan-Henning, Hoell, Jessica I |
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| description | <jats:p>Acute leukemias are genetic diseases caused by translocations or mutations, which dysregulate hematopoiesis towards malignant transformation. However, the molecular mode of action is highly versatile and ranges from direct transcriptional to post-transcriptional control, which includes RNA-binding proteins (RBPs) as crucial regulators of cell fate. RBPs coordinate RNA dynamics, including subcellular localization, translational efficiency and metabolism, by binding to their target messenger RNAs (mRNAs), thereby controlling the expression of the encoded proteins. In view of the growing interest in these regulators, this review summarizes recent research regarding the most influential RBPs relevant in acute leukemias in particular. The reported RBPs, either dysregulated or as components of fusion proteins, are described with respect to their functional domains, the pathways they affect, and clinical aspects associated with their dysregulation or altered functions.</jats:p> |
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| spelling | Schuschel, Konstantin Helwig, Matthias Hüttelmaier, Stefan Heckl, Dirk Klusmann, Jan-Henning Hoell, Jessica I 1422-0067 MDPI AG Inorganic Chemistry Organic Chemistry Physical and Theoretical Chemistry Computer Science Applications Spectroscopy Molecular Biology General Medicine Catalysis http://dx.doi.org/10.3390/ijms21103409 <jats:p>Acute leukemias are genetic diseases caused by translocations or mutations, which dysregulate hematopoiesis towards malignant transformation. However, the molecular mode of action is highly versatile and ranges from direct transcriptional to post-transcriptional control, which includes RNA-binding proteins (RBPs) as crucial regulators of cell fate. RBPs coordinate RNA dynamics, including subcellular localization, translational efficiency and metabolism, by binding to their target messenger RNAs (mRNAs), thereby controlling the expression of the encoded proteins. In view of the growing interest in these regulators, this review summarizes recent research regarding the most influential RBPs relevant in acute leukemias in particular. The reported RBPs, either dysregulated or as components of fusion proteins, are described with respect to their functional domains, the pathways they affect, and clinical aspects associated with their dysregulation or altered functions.</jats:p> RNA-Binding Proteins in Acute Leukemias International Journal of Molecular Sciences |
| spellingShingle | Schuschel, Konstantin, Helwig, Matthias, Hüttelmaier, Stefan, Heckl, Dirk, Klusmann, Jan-Henning, Hoell, Jessica I, International Journal of Molecular Sciences, RNA-Binding Proteins in Acute Leukemias, Inorganic Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Computer Science Applications, Spectroscopy, Molecular Biology, General Medicine, Catalysis |
| title | RNA-Binding Proteins in Acute Leukemias |
| title_full | RNA-Binding Proteins in Acute Leukemias |
| title_fullStr | RNA-Binding Proteins in Acute Leukemias |
| title_full_unstemmed | RNA-Binding Proteins in Acute Leukemias |
| title_short | RNA-Binding Proteins in Acute Leukemias |
| title_sort | rna-binding proteins in acute leukemias |
| title_unstemmed | RNA-Binding Proteins in Acute Leukemias |
| topic | Inorganic Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Computer Science Applications, Spectroscopy, Molecular Biology, General Medicine, Catalysis |
| url | http://dx.doi.org/10.3390/ijms21103409 |