RNA-Binding Proteins in Acute Leukemias

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Bibliographische Detailangaben
Zeitschriftentitel:	International Journal of Molecular Sciences
Personen und Körperschaften:	Schuschel, Konstantin, Helwig, Matthias, Hüttelmaier, Stefan, Heckl, Dirk, Klusmann, Jan-Henning, Hoell, Jessica I
In:	International Journal of Molecular Sciences, 21, 2020, 10, S. 3409
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	MDPI AG
Schlagwörter:	Inorganic Chemistry Organic Chemistry Physical and Theoretical Chemistry Computer Science Applications Spectroscopy Molecular Biology General Medicine Catalysis

Details
Zusammenfassung:	<jats:p>Acute leukemias are genetic diseases caused by translocations or mutations, which dysregulate hematopoiesis towards malignant transformation. However, the molecular mode of action is highly versatile and ranges from direct transcriptional to post-transcriptional control, which includes RNA-binding proteins (RBPs) as crucial regulators of cell fate. RBPs coordinate RNA dynamics, including subcellular localization, translational efficiency and metabolism, by binding to their target messenger RNAs (mRNAs), thereby controlling the expression of the encoded proteins. In view of the growing interest in these regulators, this review summarizes recent research regarding the most influential RBPs relevant in acute leukemias in particular. The reported RBPs, either dysregulated or as components of fusion proteins, are described with respect to their functional domains, the pathways they affect, and clinical aspects associated with their dysregulation or altered functions.</jats:p>
Umfang:	3409
ISSN:	1422-0067
DOI:	10.3390/ijms21103409