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Hes1 Regulates Corneal Development and the Function of Corneal Epithelial Stem/Progenitor Cells
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| Zeitschriftentitel: | Stem Cells |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Stem Cells, 26, 2008, 5, S. 1265-1274 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Oxford University Press (OUP)
|
| Schlagwörter: |
| author_facet |
Nakamura, Takahiro Ohtsuka, Toshiyuki Sekiyama, Eiichi Cooper, Leanne J. Kokubu, Hiroshi Fullwood, Nigel J. Barrandon, Yann Kageyama, Ryoichiro Kinoshita, Shigeru Nakamura, Takahiro Ohtsuka, Toshiyuki Sekiyama, Eiichi Cooper, Leanne J. Kokubu, Hiroshi Fullwood, Nigel J. Barrandon, Yann Kageyama, Ryoichiro Kinoshita, Shigeru |
|---|---|
| author |
Nakamura, Takahiro Ohtsuka, Toshiyuki Sekiyama, Eiichi Cooper, Leanne J. Kokubu, Hiroshi Fullwood, Nigel J. Barrandon, Yann Kageyama, Ryoichiro Kinoshita, Shigeru |
| spellingShingle |
Nakamura, Takahiro Ohtsuka, Toshiyuki Sekiyama, Eiichi Cooper, Leanne J. Kokubu, Hiroshi Fullwood, Nigel J. Barrandon, Yann Kageyama, Ryoichiro Kinoshita, Shigeru Stem Cells Hes1 Regulates Corneal Development and the Function of Corneal Epithelial Stem/Progenitor Cells Cell Biology Developmental Biology Molecular Medicine |
| author_sort |
nakamura, takahiro |
| spelling |
Nakamura, Takahiro Ohtsuka, Toshiyuki Sekiyama, Eiichi Cooper, Leanne J. Kokubu, Hiroshi Fullwood, Nigel J. Barrandon, Yann Kageyama, Ryoichiro Kinoshita, Shigeru 1066-5099 1549-4918 Oxford University Press (OUP) Cell Biology Developmental Biology Molecular Medicine http://dx.doi.org/10.1634/stemcells.2007-1067 <jats:title>Abstract</jats:title> <jats:p>Hes1, a major target gene in Notch signaling, regulates the fate and differentiation of various cell types in many developmental systems. To gain a novel insight into the role of Hes1 in corneal tissue, we performed gain-of-function and loss-of-function studies. We show that corneal development was severely disturbed in Hes1-null mice. Hes1-null corneas manifested abnormal junctional specialization, cell differentiation, and less cell proliferation ability. Worthy of note, Hes1 is expressed mainly in the corneal epithelial stem/progenitor cells and is not detected in the differentiated corneal epithelial cells. Expression of Hes1 is closely linked with corneal epithelial stem/progenitor cell proliferation activity in vivo. Moreover, forced Hes1 expression inhibits the differentiation of corneal epithelial stem/progenitor cells and maintains these cells' undifferentiated state. Our data provide the first evidence that Hes1 regulates corneal development and the homeostatic function of corneal epithelial stem/progenitor cells.</jats:p> <jats:p>Disclosure of potential conflicts of interest is found at the end of this article.</jats:p> Hes1 Regulates Corneal Development and the Function of Corneal Epithelial Stem/Progenitor Cells Stem Cells |
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Oxford University Press (OUP), 2008 |
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Oxford University Press (OUP), 2008 |
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| title |
Hes1 Regulates Corneal Development and the Function of Corneal Epithelial Stem/Progenitor Cells |
| title_unstemmed |
Hes1 Regulates Corneal Development and the Function of Corneal Epithelial Stem/Progenitor Cells |
| title_full |
Hes1 Regulates Corneal Development and the Function of Corneal Epithelial Stem/Progenitor Cells |
| title_fullStr |
Hes1 Regulates Corneal Development and the Function of Corneal Epithelial Stem/Progenitor Cells |
| title_full_unstemmed |
Hes1 Regulates Corneal Development and the Function of Corneal Epithelial Stem/Progenitor Cells |
| title_short |
Hes1 Regulates Corneal Development and the Function of Corneal Epithelial Stem/Progenitor Cells |
| title_sort |
hes1 regulates corneal development and the function of corneal epithelial stem/progenitor cells |
| topic |
Cell Biology Developmental Biology Molecular Medicine |
| url |
http://dx.doi.org/10.1634/stemcells.2007-1067 |
| publishDate |
2008 |
| physical |
1265-1274 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Hes1, a major target gene in Notch signaling, regulates the fate and differentiation of various cell types in many developmental systems. To gain a novel insight into the role of Hes1 in corneal tissue, we performed gain-of-function and loss-of-function studies. We show that corneal development was severely disturbed in Hes1-null mice. Hes1-null corneas manifested abnormal junctional specialization, cell differentiation, and less cell proliferation ability. Worthy of note, Hes1 is expressed mainly in the corneal epithelial stem/progenitor cells and is not detected in the differentiated corneal epithelial cells. Expression of Hes1 is closely linked with corneal epithelial stem/progenitor cell proliferation activity in vivo. Moreover, forced Hes1 expression inhibits the differentiation of corneal epithelial stem/progenitor cells and maintains these cells' undifferentiated state. Our data provide the first evidence that Hes1 regulates corneal development and the homeostatic function of corneal epithelial stem/progenitor cells.</jats:p>
<jats:p>Disclosure of potential conflicts of interest is found at the end of this article.</jats:p> |
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| author | Nakamura, Takahiro, Ohtsuka, Toshiyuki, Sekiyama, Eiichi, Cooper, Leanne J., Kokubu, Hiroshi, Fullwood, Nigel J., Barrandon, Yann, Kageyama, Ryoichiro, Kinoshita, Shigeru |
| author_facet | Nakamura, Takahiro, Ohtsuka, Toshiyuki, Sekiyama, Eiichi, Cooper, Leanne J., Kokubu, Hiroshi, Fullwood, Nigel J., Barrandon, Yann, Kageyama, Ryoichiro, Kinoshita, Shigeru, Nakamura, Takahiro, Ohtsuka, Toshiyuki, Sekiyama, Eiichi, Cooper, Leanne J., Kokubu, Hiroshi, Fullwood, Nigel J., Barrandon, Yann, Kageyama, Ryoichiro, Kinoshita, Shigeru |
| author_sort | nakamura, takahiro |
| container_issue | 5 |
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| description | <jats:title>Abstract</jats:title> <jats:p>Hes1, a major target gene in Notch signaling, regulates the fate and differentiation of various cell types in many developmental systems. To gain a novel insight into the role of Hes1 in corneal tissue, we performed gain-of-function and loss-of-function studies. We show that corneal development was severely disturbed in Hes1-null mice. Hes1-null corneas manifested abnormal junctional specialization, cell differentiation, and less cell proliferation ability. Worthy of note, Hes1 is expressed mainly in the corneal epithelial stem/progenitor cells and is not detected in the differentiated corneal epithelial cells. Expression of Hes1 is closely linked with corneal epithelial stem/progenitor cell proliferation activity in vivo. Moreover, forced Hes1 expression inhibits the differentiation of corneal epithelial stem/progenitor cells and maintains these cells' undifferentiated state. Our data provide the first evidence that Hes1 regulates corneal development and the homeostatic function of corneal epithelial stem/progenitor cells.</jats:p> <jats:p>Disclosure of potential conflicts of interest is found at the end of this article.</jats:p> |
| doi_str_mv | 10.1634/stemcells.2007-1067 |
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| imprint | Oxford University Press (OUP), 2008 |
| imprint_str_mv | Oxford University Press (OUP), 2008 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 1066-5099, 1549-4918 |
| issn_str_mv | 1066-5099, 1549-4918 |
| language | English |
| last_indexed | 2024-03-01T14:48:14.091Z |
| match_str | nakamura2008hes1regulatescornealdevelopmentandthefunctionofcornealepithelialstemprogenitorcells |
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| physical | 1265-1274 |
| publishDate | 2008 |
| publishDateSort | 2008 |
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| spelling | Nakamura, Takahiro Ohtsuka, Toshiyuki Sekiyama, Eiichi Cooper, Leanne J. Kokubu, Hiroshi Fullwood, Nigel J. Barrandon, Yann Kageyama, Ryoichiro Kinoshita, Shigeru 1066-5099 1549-4918 Oxford University Press (OUP) Cell Biology Developmental Biology Molecular Medicine http://dx.doi.org/10.1634/stemcells.2007-1067 <jats:title>Abstract</jats:title> <jats:p>Hes1, a major target gene in Notch signaling, regulates the fate and differentiation of various cell types in many developmental systems. To gain a novel insight into the role of Hes1 in corneal tissue, we performed gain-of-function and loss-of-function studies. We show that corneal development was severely disturbed in Hes1-null mice. Hes1-null corneas manifested abnormal junctional specialization, cell differentiation, and less cell proliferation ability. Worthy of note, Hes1 is expressed mainly in the corneal epithelial stem/progenitor cells and is not detected in the differentiated corneal epithelial cells. Expression of Hes1 is closely linked with corneal epithelial stem/progenitor cell proliferation activity in vivo. Moreover, forced Hes1 expression inhibits the differentiation of corneal epithelial stem/progenitor cells and maintains these cells' undifferentiated state. Our data provide the first evidence that Hes1 regulates corneal development and the homeostatic function of corneal epithelial stem/progenitor cells.</jats:p> <jats:p>Disclosure of potential conflicts of interest is found at the end of this article.</jats:p> Hes1 Regulates Corneal Development and the Function of Corneal Epithelial Stem/Progenitor Cells Stem Cells |
| spellingShingle | Nakamura, Takahiro, Ohtsuka, Toshiyuki, Sekiyama, Eiichi, Cooper, Leanne J., Kokubu, Hiroshi, Fullwood, Nigel J., Barrandon, Yann, Kageyama, Ryoichiro, Kinoshita, Shigeru, Stem Cells, Hes1 Regulates Corneal Development and the Function of Corneal Epithelial Stem/Progenitor Cells, Cell Biology, Developmental Biology, Molecular Medicine |
| title | Hes1 Regulates Corneal Development and the Function of Corneal Epithelial Stem/Progenitor Cells |
| title_full | Hes1 Regulates Corneal Development and the Function of Corneal Epithelial Stem/Progenitor Cells |
| title_fullStr | Hes1 Regulates Corneal Development and the Function of Corneal Epithelial Stem/Progenitor Cells |
| title_full_unstemmed | Hes1 Regulates Corneal Development and the Function of Corneal Epithelial Stem/Progenitor Cells |
| title_short | Hes1 Regulates Corneal Development and the Function of Corneal Epithelial Stem/Progenitor Cells |
| title_sort | hes1 regulates corneal development and the function of corneal epithelial stem/progenitor cells |
| title_unstemmed | Hes1 Regulates Corneal Development and the Function of Corneal Epithelial Stem/Progenitor Cells |
| topic | Cell Biology, Developmental Biology, Molecular Medicine |
| url | http://dx.doi.org/10.1634/stemcells.2007-1067 |