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Hes1 Regulates Corneal Development and the Function of Corneal Epithelial Stem/Progenitor Cells
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| Zeitschriftentitel: | Stem Cells |
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| Personen und Körperschaften: | , , , , , , , , |
| In: | Stem Cells, 26, 2008, 5, S. 1265-1274 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Oxford University Press (OUP)
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| Schlagwörter: |
| Zusammenfassung: | <jats:title>Abstract</jats:title> <jats:p>Hes1, a major target gene in Notch signaling, regulates the fate and differentiation of various cell types in many developmental systems. To gain a novel insight into the role of Hes1 in corneal tissue, we performed gain-of-function and loss-of-function studies. We show that corneal development was severely disturbed in Hes1-null mice. Hes1-null corneas manifested abnormal junctional specialization, cell differentiation, and less cell proliferation ability. Worthy of note, Hes1 is expressed mainly in the corneal epithelial stem/progenitor cells and is not detected in the differentiated corneal epithelial cells. Expression of Hes1 is closely linked with corneal epithelial stem/progenitor cell proliferation activity in vivo. Moreover, forced Hes1 expression inhibits the differentiation of corneal epithelial stem/progenitor cells and maintains these cells' undifferentiated state. Our data provide the first evidence that Hes1 regulates corneal development and the homeostatic function of corneal epithelial stem/progenitor cells.</jats:p> <jats:p>Disclosure of potential conflicts of interest is found at the end of this article.</jats:p> |
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| Umfang: | 1265-1274 |
| ISSN: |
1066-5099
1549-4918 |
| DOI: | 10.1634/stemcells.2007-1067 |