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Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin
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| Zeitschriftentitel: | The Journal of Neuroscience |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | The Journal of Neuroscience, 30, 2010, 30, S. 9984-9989 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Society for Neuroscience
|
| Schlagwörter: |
| author_facet |
Bozdagi, Ozlem Wang, Xiao-bin Nikitczuk, Jessica S. Anderson, Tonya R. Bloss, Erik B. Radice, Glenn L. Zhou, Qiang Benson, Deanna L. Huntley, George W. Bozdagi, Ozlem Wang, Xiao-bin Nikitczuk, Jessica S. Anderson, Tonya R. Bloss, Erik B. Radice, Glenn L. Zhou, Qiang Benson, Deanna L. Huntley, George W. |
|---|---|
| author |
Bozdagi, Ozlem Wang, Xiao-bin Nikitczuk, Jessica S. Anderson, Tonya R. Bloss, Erik B. Radice, Glenn L. Zhou, Qiang Benson, Deanna L. Huntley, George W. |
| spellingShingle |
Bozdagi, Ozlem Wang, Xiao-bin Nikitczuk, Jessica S. Anderson, Tonya R. Bloss, Erik B. Radice, Glenn L. Zhou, Qiang Benson, Deanna L. Huntley, George W. The Journal of Neuroscience Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin General Neuroscience |
| author_sort |
bozdagi, ozlem |
| spelling |
Bozdagi, Ozlem Wang, Xiao-bin Nikitczuk, Jessica S. Anderson, Tonya R. Bloss, Erik B. Radice, Glenn L. Zhou, Qiang Benson, Deanna L. Huntley, George W. 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.1223-10.2010 <jats:p>Persistent changes in spine shape are coupled to long-lasting synaptic plasticity in hippocampus. The molecules that coordinate such persistent structural and functional plasticity are unknown. Here, we generated mice in which the cell adhesion molecule N-cadherin was conditionally ablated from postnatal, excitatory synapses in hippocampus. We applied to adult mice of either sex a combination of whole-cell recording, two-photon microscopy, and spine morphometric analysis to show that postnatal ablation of N-cadherin has profound effects on the stability of coordinated spine enlargement and long-term potentiation (LTP) at mature CA1 synapses, with no effects on baseline spine density or morphology, baseline properties of synaptic neurotransmission, or long-term depression. Thus, N-cadherin couples persistent spine structural modifications with long-lasting synaptic functional modifications associated selectively with LTP, revealing unexpectedly distinct roles at mature synapses in comparison with earlier, broader functions in synapse and spine development.</jats:p> Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin The Journal of Neuroscience |
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| title |
Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin |
| title_unstemmed |
Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin |
| title_full |
Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin |
| title_fullStr |
Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin |
| title_full_unstemmed |
Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin |
| title_short |
Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin |
| title_sort |
persistence of coordinated long-term potentiation and dendritic spine enlargement at mature hippocampal ca1 synapses requires n-cadherin |
| topic |
General Neuroscience |
| url |
http://dx.doi.org/10.1523/jneurosci.1223-10.2010 |
| publishDate |
2010 |
| physical |
9984-9989 |
| description |
<jats:p>Persistent changes in spine shape are coupled to long-lasting synaptic plasticity in hippocampus. The molecules that coordinate such persistent structural and functional plasticity are unknown. Here, we generated mice in which the cell adhesion molecule N-cadherin was conditionally ablated from postnatal, excitatory synapses in hippocampus. We applied to adult mice of either sex a combination of whole-cell recording, two-photon microscopy, and spine morphometric analysis to show that postnatal ablation of N-cadherin has profound effects on the stability of coordinated spine enlargement and long-term potentiation (LTP) at mature CA1 synapses, with no effects on baseline spine density or morphology, baseline properties of synaptic neurotransmission, or long-term depression. Thus, N-cadherin couples persistent spine structural modifications with long-lasting synaptic functional modifications associated selectively with LTP, revealing unexpectedly distinct roles at mature synapses in comparison with earlier, broader functions in synapse and spine development.</jats:p> |
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| author | Bozdagi, Ozlem, Wang, Xiao-bin, Nikitczuk, Jessica S., Anderson, Tonya R., Bloss, Erik B., Radice, Glenn L., Zhou, Qiang, Benson, Deanna L., Huntley, George W. |
| author_facet | Bozdagi, Ozlem, Wang, Xiao-bin, Nikitczuk, Jessica S., Anderson, Tonya R., Bloss, Erik B., Radice, Glenn L., Zhou, Qiang, Benson, Deanna L., Huntley, George W., Bozdagi, Ozlem, Wang, Xiao-bin, Nikitczuk, Jessica S., Anderson, Tonya R., Bloss, Erik B., Radice, Glenn L., Zhou, Qiang, Benson, Deanna L., Huntley, George W. |
| author_sort | bozdagi, ozlem |
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| description | <jats:p>Persistent changes in spine shape are coupled to long-lasting synaptic plasticity in hippocampus. The molecules that coordinate such persistent structural and functional plasticity are unknown. Here, we generated mice in which the cell adhesion molecule N-cadherin was conditionally ablated from postnatal, excitatory synapses in hippocampus. We applied to adult mice of either sex a combination of whole-cell recording, two-photon microscopy, and spine morphometric analysis to show that postnatal ablation of N-cadherin has profound effects on the stability of coordinated spine enlargement and long-term potentiation (LTP) at mature CA1 synapses, with no effects on baseline spine density or morphology, baseline properties of synaptic neurotransmission, or long-term depression. Thus, N-cadherin couples persistent spine structural modifications with long-lasting synaptic functional modifications associated selectively with LTP, revealing unexpectedly distinct roles at mature synapses in comparison with earlier, broader functions in synapse and spine development.</jats:p> |
| doi_str_mv | 10.1523/jneurosci.1223-10.2010 |
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| imprint_str_mv | Society for Neuroscience, 2010 |
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| physical | 9984-9989 |
| publishDate | 2010 |
| publishDateSort | 2010 |
| publisher | Society for Neuroscience |
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| series | The Journal of Neuroscience |
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| spelling | Bozdagi, Ozlem Wang, Xiao-bin Nikitczuk, Jessica S. Anderson, Tonya R. Bloss, Erik B. Radice, Glenn L. Zhou, Qiang Benson, Deanna L. Huntley, George W. 0270-6474 1529-2401 Society for Neuroscience General Neuroscience http://dx.doi.org/10.1523/jneurosci.1223-10.2010 <jats:p>Persistent changes in spine shape are coupled to long-lasting synaptic plasticity in hippocampus. The molecules that coordinate such persistent structural and functional plasticity are unknown. Here, we generated mice in which the cell adhesion molecule N-cadherin was conditionally ablated from postnatal, excitatory synapses in hippocampus. We applied to adult mice of either sex a combination of whole-cell recording, two-photon microscopy, and spine morphometric analysis to show that postnatal ablation of N-cadherin has profound effects on the stability of coordinated spine enlargement and long-term potentiation (LTP) at mature CA1 synapses, with no effects on baseline spine density or morphology, baseline properties of synaptic neurotransmission, or long-term depression. Thus, N-cadherin couples persistent spine structural modifications with long-lasting synaptic functional modifications associated selectively with LTP, revealing unexpectedly distinct roles at mature synapses in comparison with earlier, broader functions in synapse and spine development.</jats:p> Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin The Journal of Neuroscience |
| spellingShingle | Bozdagi, Ozlem, Wang, Xiao-bin, Nikitczuk, Jessica S., Anderson, Tonya R., Bloss, Erik B., Radice, Glenn L., Zhou, Qiang, Benson, Deanna L., Huntley, George W., The Journal of Neuroscience, Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin, General Neuroscience |
| title | Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin |
| title_full | Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin |
| title_fullStr | Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin |
| title_full_unstemmed | Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin |
| title_short | Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin |
| title_sort | persistence of coordinated long-term potentiation and dendritic spine enlargement at mature hippocampal ca1 synapses requires n-cadherin |
| title_unstemmed | Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin |
| topic | General Neuroscience |
| url | http://dx.doi.org/10.1523/jneurosci.1223-10.2010 |