Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin

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Bibliographische Detailangaben
Zeitschriftentitel:	The Journal of Neuroscience
Personen und Körperschaften:	Bozdagi, Ozlem, Wang, Xiao-bin, Nikitczuk, Jessica S., Anderson, Tonya R., Bloss, Erik B., Radice, Glenn L., Zhou, Qiang, Benson, Deanna L., Huntley, George W.
In:	The Journal of Neuroscience, 30, 2010, 30, S. 9984-9989
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	Society for Neuroscience
Schlagwörter:	General Neuroscience

Details
Zusammenfassung:	<jats:p>Persistent changes in spine shape are coupled to long-lasting synaptic plasticity in hippocampus. The molecules that coordinate such persistent structural and functional plasticity are unknown. Here, we generated mice in which the cell adhesion molecule N-cadherin was conditionally ablated from postnatal, excitatory synapses in hippocampus. We applied to adult mice of either sex a combination of whole-cell recording, two-photon microscopy, and spine morphometric analysis to show that postnatal ablation of N-cadherin has profound effects on the stability of coordinated spine enlargement and long-term potentiation (LTP) at mature CA1 synapses, with no effects on baseline spine density or morphology, baseline properties of synaptic neurotransmission, or long-term depression. Thus, N-cadherin couples persistent spine structural modifications with long-lasting synaptic functional modifications associated selectively with LTP, revealing unexpectedly distinct roles at mature synapses in comparison with earlier, broader functions in synapse and spine development.</jats:p>
Umfang:	9984-9989
ISSN:	0270-6474 1529-2401
DOI:	10.1523/jneurosci.1223-10.2010