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Familial Risks Between Urolithiasis and Cancer
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| Zeitschriftentitel: | Journal of Global Oncology |
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| Personen und Körperschaften: | |
| In: | Journal of Global Oncology, 4, 2018, Supplement 2, S. 13s-13s |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Clinical Oncology (ASCO)
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| Schlagwörter: |
| Zusammenfassung: | <jats:p> Background: Urolithiasis (UL, urinary tract stone disease) has been reported to increase subsequent cancers in the urinary tract. Recently, we showed data that surveillance bias may be an important confounder in the reported associations. Aim: In the present approach we want to address the question of possible cancer risk posed by UL mechanistically. Both UL and cancer have strong genetic components and we hypothesize that familial association between UL and cancer may be plausible. We thus assess familial risks between UL and cancer, hoping to find an explanation why UL may pose a risk of cancer. Methods: UL patients were identified from hospital inpatient and outpatient records and they were organized in families based on the multigeneration register into which also national cancer data were linked. Standardized incidence ratios were calculated for cancer in the offspring generation when parents were diagnosed with UL, and conversely for UL when parents were diagnosed with cancer. Results: Familial risks between UL and cancer were generally small and inconsistent providing no convincing support of genetic sharing between UL and cancer. However, bladder UL was associated weakly with prostate cancer, and ureter and bladder UL were associated with salivary gland cancer. The current study did not provide data in support of UL leading to systemic cancers. Nor did we find any strong support for the induction of local tumors in the urinary tract; however, as the cause for local tumors may be chronic mechanical wear and inflammation, a family study may not find such a link. Conclusion: We found support for a weak familial association of bladder UL and prostate cancer but could not distinguish between genetic or familial prostate hyperplasia mechanisms. Unexpected findings showed associations of ureter and bladder UL with salivary gland cancers. The likely initial link was familial predisposition to both salivary gland and urinary tract stones but the necessary final link between salivary gland stones and salivary gland cancer needs yet to be demonstrated. </jats:p> |
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| Umfang: | 13s-13s |
| ISSN: |
2378-9506
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| DOI: | 10.1200/jgo.18.43000 |