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A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum
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| Zeitschriftentitel: | mBio |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | mBio, 10, 2019, 4 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| author_facet |
Jacquier, Nicolas Yadav, Akhilesh K. Pillonel, Trestan Viollier, Patrick H. Cava, Felipe Greub, Gilbert Jacquier, Nicolas Yadav, Akhilesh K. Pillonel, Trestan Viollier, Patrick H. Cava, Felipe Greub, Gilbert |
|---|---|
| author |
Jacquier, Nicolas Yadav, Akhilesh K. Pillonel, Trestan Viollier, Patrick H. Cava, Felipe Greub, Gilbert |
| spellingShingle |
Jacquier, Nicolas Yadav, Akhilesh K. Pillonel, Trestan Viollier, Patrick H. Cava, Felipe Greub, Gilbert mBio A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum Virology Microbiology |
| author_sort |
jacquier, nicolas |
| spelling |
Jacquier, Nicolas Yadav, Akhilesh K. Pillonel, Trestan Viollier, Patrick H. Cava, Felipe Greub, Gilbert 2161-2129 2150-7511 American Society for Microbiology Virology Microbiology http://dx.doi.org/10.1128/mbio.01128-19 <jats:p> <jats:italic>Chlamydiales</jats:italic> species are obligate intracellular bacteria and important human pathogens that have a minimal division machinery lacking the proteins that are essential for bacterial division in other species, such as FtsZ. Chlamydial division requires synthesis of peptidoglycan, which forms a ring at the division septum and is rapidly turned over. However, little is known of peptidoglycan degradation, because many peptidoglycan-degrading enzymes are not encoded by chlamydial genomes. Here we show that an homologue of SpoIID, a peptidoglycan-degrading enzyme involved in sporulation of bacteria such as <jats:named-content content-type="genus-species">Bacillus subtilis</jats:named-content> , is expressed in <jats:italic>Chlamydiales</jats:italic> , localizes at the division septum, and degrades peptidoglycan <jats:italic>in vitro</jats:italic> , indicating that SpoIID is not only involved in sporulation but also likely implicated in division of some bacteria. </jats:p> A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum mBio |
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| title |
A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum |
| title_unstemmed |
A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum |
| title_full |
A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum |
| title_fullStr |
A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum |
| title_full_unstemmed |
A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum |
| title_short |
A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum |
| title_sort |
a spoiid homolog cleaves glycan strands at the chlamydial division septum |
| topic |
Virology Microbiology |
| url |
http://dx.doi.org/10.1128/mbio.01128-19 |
| publishDate |
2019 |
| physical |
|
| description |
<jats:p>
<jats:italic>Chlamydiales</jats:italic>
species are obligate intracellular bacteria and important human pathogens that have a minimal division machinery lacking the proteins that are essential for bacterial division in other species, such as FtsZ. Chlamydial division requires synthesis of peptidoglycan, which forms a ring at the division septum and is rapidly turned over. However, little is known of peptidoglycan degradation, because many peptidoglycan-degrading enzymes are not encoded by chlamydial genomes. Here we show that an homologue of SpoIID, a peptidoglycan-degrading enzyme involved in sporulation of bacteria such as
<jats:named-content content-type="genus-species">Bacillus subtilis</jats:named-content>
, is expressed in
<jats:italic>Chlamydiales</jats:italic>
, localizes at the division septum, and degrades peptidoglycan
<jats:italic>in vitro</jats:italic>
, indicating that SpoIID is not only involved in sporulation but also likely implicated in division of some bacteria.
</jats:p> |
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| author | Jacquier, Nicolas, Yadav, Akhilesh K., Pillonel, Trestan, Viollier, Patrick H., Cava, Felipe, Greub, Gilbert |
| author_facet | Jacquier, Nicolas, Yadav, Akhilesh K., Pillonel, Trestan, Viollier, Patrick H., Cava, Felipe, Greub, Gilbert, Jacquier, Nicolas, Yadav, Akhilesh K., Pillonel, Trestan, Viollier, Patrick H., Cava, Felipe, Greub, Gilbert |
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| description | <jats:p> <jats:italic>Chlamydiales</jats:italic> species are obligate intracellular bacteria and important human pathogens that have a minimal division machinery lacking the proteins that are essential for bacterial division in other species, such as FtsZ. Chlamydial division requires synthesis of peptidoglycan, which forms a ring at the division septum and is rapidly turned over. However, little is known of peptidoglycan degradation, because many peptidoglycan-degrading enzymes are not encoded by chlamydial genomes. Here we show that an homologue of SpoIID, a peptidoglycan-degrading enzyme involved in sporulation of bacteria such as <jats:named-content content-type="genus-species">Bacillus subtilis</jats:named-content> , is expressed in <jats:italic>Chlamydiales</jats:italic> , localizes at the division septum, and degrades peptidoglycan <jats:italic>in vitro</jats:italic> , indicating that SpoIID is not only involved in sporulation but also likely implicated in division of some bacteria. </jats:p> |
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| spelling | Jacquier, Nicolas Yadav, Akhilesh K. Pillonel, Trestan Viollier, Patrick H. Cava, Felipe Greub, Gilbert 2161-2129 2150-7511 American Society for Microbiology Virology Microbiology http://dx.doi.org/10.1128/mbio.01128-19 <jats:p> <jats:italic>Chlamydiales</jats:italic> species are obligate intracellular bacteria and important human pathogens that have a minimal division machinery lacking the proteins that are essential for bacterial division in other species, such as FtsZ. Chlamydial division requires synthesis of peptidoglycan, which forms a ring at the division septum and is rapidly turned over. However, little is known of peptidoglycan degradation, because many peptidoglycan-degrading enzymes are not encoded by chlamydial genomes. Here we show that an homologue of SpoIID, a peptidoglycan-degrading enzyme involved in sporulation of bacteria such as <jats:named-content content-type="genus-species">Bacillus subtilis</jats:named-content> , is expressed in <jats:italic>Chlamydiales</jats:italic> , localizes at the division septum, and degrades peptidoglycan <jats:italic>in vitro</jats:italic> , indicating that SpoIID is not only involved in sporulation but also likely implicated in division of some bacteria. </jats:p> A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum mBio |
| spellingShingle | Jacquier, Nicolas, Yadav, Akhilesh K., Pillonel, Trestan, Viollier, Patrick H., Cava, Felipe, Greub, Gilbert, mBio, A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum, Virology, Microbiology |
| title | A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum |
| title_full | A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum |
| title_fullStr | A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum |
| title_full_unstemmed | A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum |
| title_short | A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum |
| title_sort | a spoiid homolog cleaves glycan strands at the chlamydial division septum |
| title_unstemmed | A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum |
| topic | Virology, Microbiology |
| url | http://dx.doi.org/10.1128/mbio.01128-19 |