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A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum
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| Zeitschriftentitel: | mBio |
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| Personen und Körperschaften: | , , , , , |
| In: | mBio, 10, 2019, 4 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| Zusammenfassung: | <jats:p> <jats:italic>Chlamydiales</jats:italic> species are obligate intracellular bacteria and important human pathogens that have a minimal division machinery lacking the proteins that are essential for bacterial division in other species, such as FtsZ. Chlamydial division requires synthesis of peptidoglycan, which forms a ring at the division septum and is rapidly turned over. However, little is known of peptidoglycan degradation, because many peptidoglycan-degrading enzymes are not encoded by chlamydial genomes. Here we show that an homologue of SpoIID, a peptidoglycan-degrading enzyme involved in sporulation of bacteria such as <jats:named-content content-type="genus-species">Bacillus subtilis</jats:named-content> , is expressed in <jats:italic>Chlamydiales</jats:italic> , localizes at the division septum, and degrades peptidoglycan <jats:italic>in vitro</jats:italic> , indicating that SpoIID is not only involved in sporulation but also likely implicated in division of some bacteria. </jats:p> |
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| ISSN: |
2161-2129
2150-7511 |
| DOI: | 10.1128/mbio.01128-19 |