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Programmed Delay of a Virulence Circuit Promotes Salmonella Pathogenicity
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| Zeitschriftentitel: | mBio |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | mBio, 10, 2019, 2 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| author_facet |
Choi, Jeongjoon Kim, Heeju Chang, Yoonjee Yoo, Woongjae Kim, Dajeong Ryu, Sangryeol Choi, Jeongjoon Kim, Heeju Chang, Yoonjee Yoo, Woongjae Kim, Dajeong Ryu, Sangryeol |
|---|---|
| author |
Choi, Jeongjoon Kim, Heeju Chang, Yoonjee Yoo, Woongjae Kim, Dajeong Ryu, Sangryeol |
| spellingShingle |
Choi, Jeongjoon Kim, Heeju Chang, Yoonjee Yoo, Woongjae Kim, Dajeong Ryu, Sangryeol mBio Programmed Delay of a Virulence Circuit Promotes Salmonella Pathogenicity Virology Microbiology |
| author_sort |
choi, jeongjoon |
| spelling |
Choi, Jeongjoon Kim, Heeju Chang, Yoonjee Yoo, Woongjae Kim, Dajeong Ryu, Sangryeol 2161-2129 2150-7511 American Society for Microbiology Virology Microbiology http://dx.doi.org/10.1128/mbio.00291-19 <jats:p> To accomplish successful infection, pathogens must operate their virulence programs in a precise, time-sensitive, and coordinated manner. A major question is how pathogens control the timing of virulence gene expression during infection. Here we report that the intracellular pathogen <jats:italic>Salmonella</jats:italic> controls the timing and level of virulence gene expression by using an inhibitory protein, EIIA <jats:sup>Ntr</jats:sup> . A DNA binding master virulence regulator, PhoP, controls various virulence genes inside acidic phagosomes. <jats:italic>Salmonella</jats:italic> decreases EIIA <jats:sup>Ntr</jats:sup> amounts at acidic pH in a Lon- and PhoP-dependent manner. This, in turn, promotes expression of the PhoP-activated virulence program because EIIA <jats:sup>Ntr</jats:sup> hampers activation of PhoP-regulated genes by interfering with PhoP binding to DNA. EIIA <jats:sup>Ntr</jats:sup> enables <jats:italic>Salmonella</jats:italic> to impede the activation of PhoP-regulated gene expression inside macrophages. Our findings suggest that <jats:italic>Salmonella</jats:italic> achieves programmed delay of virulence gene activation by adjusting levels of an inhibitory factor. </jats:p> Programmed Delay of a Virulence Circuit Promotes <i>Salmonella</i> Pathogenicity mBio |
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10.1128/mbio.00291-19 |
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American Society for Microbiology, 2019 |
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American Society for Microbiology, 2019 |
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2161-2129 2150-7511 |
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American Society for Microbiology |
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| title |
Programmed Delay of a Virulence Circuit Promotes Salmonella Pathogenicity |
| title_unstemmed |
Programmed Delay of a Virulence Circuit Promotes Salmonella Pathogenicity |
| title_full |
Programmed Delay of a Virulence Circuit Promotes Salmonella Pathogenicity |
| title_fullStr |
Programmed Delay of a Virulence Circuit Promotes Salmonella Pathogenicity |
| title_full_unstemmed |
Programmed Delay of a Virulence Circuit Promotes Salmonella Pathogenicity |
| title_short |
Programmed Delay of a Virulence Circuit Promotes Salmonella Pathogenicity |
| title_sort |
programmed delay of a virulence circuit promotes
<i>salmonella</i>
pathogenicity |
| topic |
Virology Microbiology |
| url |
http://dx.doi.org/10.1128/mbio.00291-19 |
| publishDate |
2019 |
| physical |
|
| description |
<jats:p>
To accomplish successful infection, pathogens must operate their virulence programs in a precise, time-sensitive, and coordinated manner. A major question is how pathogens control the timing of virulence gene expression during infection. Here we report that the intracellular pathogen
<jats:italic>Salmonella</jats:italic>
controls the timing and level of virulence gene expression by using an inhibitory protein, EIIA
<jats:sup>Ntr</jats:sup>
. A DNA binding master virulence regulator, PhoP, controls various virulence genes inside acidic phagosomes.
<jats:italic>Salmonella</jats:italic>
decreases EIIA
<jats:sup>Ntr</jats:sup>
amounts at acidic pH in a Lon- and PhoP-dependent manner. This, in turn, promotes expression of the PhoP-activated virulence program because EIIA
<jats:sup>Ntr</jats:sup>
hampers activation of PhoP-regulated genes by interfering with PhoP binding to DNA. EIIA
<jats:sup>Ntr</jats:sup>
enables
<jats:italic>Salmonella</jats:italic>
to impede the activation of PhoP-regulated gene expression inside macrophages. Our findings suggest that
<jats:italic>Salmonella</jats:italic>
achieves programmed delay of virulence gene activation by adjusting levels of an inhibitory factor.
</jats:p> |
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| author | Choi, Jeongjoon, Kim, Heeju, Chang, Yoonjee, Yoo, Woongjae, Kim, Dajeong, Ryu, Sangryeol |
| author_facet | Choi, Jeongjoon, Kim, Heeju, Chang, Yoonjee, Yoo, Woongjae, Kim, Dajeong, Ryu, Sangryeol, Choi, Jeongjoon, Kim, Heeju, Chang, Yoonjee, Yoo, Woongjae, Kim, Dajeong, Ryu, Sangryeol |
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| description | <jats:p> To accomplish successful infection, pathogens must operate their virulence programs in a precise, time-sensitive, and coordinated manner. A major question is how pathogens control the timing of virulence gene expression during infection. Here we report that the intracellular pathogen <jats:italic>Salmonella</jats:italic> controls the timing and level of virulence gene expression by using an inhibitory protein, EIIA <jats:sup>Ntr</jats:sup> . A DNA binding master virulence regulator, PhoP, controls various virulence genes inside acidic phagosomes. <jats:italic>Salmonella</jats:italic> decreases EIIA <jats:sup>Ntr</jats:sup> amounts at acidic pH in a Lon- and PhoP-dependent manner. This, in turn, promotes expression of the PhoP-activated virulence program because EIIA <jats:sup>Ntr</jats:sup> hampers activation of PhoP-regulated genes by interfering with PhoP binding to DNA. EIIA <jats:sup>Ntr</jats:sup> enables <jats:italic>Salmonella</jats:italic> to impede the activation of PhoP-regulated gene expression inside macrophages. Our findings suggest that <jats:italic>Salmonella</jats:italic> achieves programmed delay of virulence gene activation by adjusting levels of an inhibitory factor. </jats:p> |
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| spelling | Choi, Jeongjoon Kim, Heeju Chang, Yoonjee Yoo, Woongjae Kim, Dajeong Ryu, Sangryeol 2161-2129 2150-7511 American Society for Microbiology Virology Microbiology http://dx.doi.org/10.1128/mbio.00291-19 <jats:p> To accomplish successful infection, pathogens must operate their virulence programs in a precise, time-sensitive, and coordinated manner. A major question is how pathogens control the timing of virulence gene expression during infection. Here we report that the intracellular pathogen <jats:italic>Salmonella</jats:italic> controls the timing and level of virulence gene expression by using an inhibitory protein, EIIA <jats:sup>Ntr</jats:sup> . A DNA binding master virulence regulator, PhoP, controls various virulence genes inside acidic phagosomes. <jats:italic>Salmonella</jats:italic> decreases EIIA <jats:sup>Ntr</jats:sup> amounts at acidic pH in a Lon- and PhoP-dependent manner. This, in turn, promotes expression of the PhoP-activated virulence program because EIIA <jats:sup>Ntr</jats:sup> hampers activation of PhoP-regulated genes by interfering with PhoP binding to DNA. EIIA <jats:sup>Ntr</jats:sup> enables <jats:italic>Salmonella</jats:italic> to impede the activation of PhoP-regulated gene expression inside macrophages. Our findings suggest that <jats:italic>Salmonella</jats:italic> achieves programmed delay of virulence gene activation by adjusting levels of an inhibitory factor. </jats:p> Programmed Delay of a Virulence Circuit Promotes <i>Salmonella</i> Pathogenicity mBio |
| spellingShingle | Choi, Jeongjoon, Kim, Heeju, Chang, Yoonjee, Yoo, Woongjae, Kim, Dajeong, Ryu, Sangryeol, mBio, Programmed Delay of a Virulence Circuit Promotes Salmonella Pathogenicity, Virology, Microbiology |
| title | Programmed Delay of a Virulence Circuit Promotes Salmonella Pathogenicity |
| title_full | Programmed Delay of a Virulence Circuit Promotes Salmonella Pathogenicity |
| title_fullStr | Programmed Delay of a Virulence Circuit Promotes Salmonella Pathogenicity |
| title_full_unstemmed | Programmed Delay of a Virulence Circuit Promotes Salmonella Pathogenicity |
| title_short | Programmed Delay of a Virulence Circuit Promotes Salmonella Pathogenicity |
| title_sort | programmed delay of a virulence circuit promotes <i>salmonella</i> pathogenicity |
| title_unstemmed | Programmed Delay of a Virulence Circuit Promotes Salmonella Pathogenicity |
| topic | Virology, Microbiology |
| url | http://dx.doi.org/10.1128/mbio.00291-19 |