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Bovine Viral Diarrhea Virus Entry Is Dependent on Clathrin-Mediated Endocytosis
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| Zeitschriftentitel: | Journal of Virology |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Journal of Virology, 79, 2005, 16, S. 10826-10829 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
|
| Schlagwörter: |
| author_facet |
Lecot, Steve Belouzard, Sandrine Dubuisson, Jean Rouillé, Yves Lecot, Steve Belouzard, Sandrine Dubuisson, Jean Rouillé, Yves |
|---|---|
| author |
Lecot, Steve Belouzard, Sandrine Dubuisson, Jean Rouillé, Yves |
| spellingShingle |
Lecot, Steve Belouzard, Sandrine Dubuisson, Jean Rouillé, Yves Journal of Virology Bovine Viral Diarrhea Virus Entry Is Dependent on Clathrin-Mediated Endocytosis Virology Insect Science Immunology Microbiology |
| author_sort |
lecot, steve |
| spelling |
Lecot, Steve Belouzard, Sandrine Dubuisson, Jean Rouillé, Yves 0022-538X 1098-5514 American Society for Microbiology Virology Insect Science Immunology Microbiology http://dx.doi.org/10.1128/jvi.79.16.10826-10829.2005 <jats:title>ABSTRACT</jats:title> <jats:p>Cellular mechanisms of bovine viral diarrhea virus (BVDV) entry in MDBK cells were investigated. Chloroquine, bafilomycin A1, or ammonium chloride inhibited BVDV infection, indicating that an acidic endosomal pH is required for BVDV entry. The tyrosine kinase inhibitor genistein partially inhibited BVDV infection at a postentry step, whereas BVDV entry was strongly inhibited by chlorpromazine or by the overexpression of a dominant-negative form of EPS15, a protein essential for the formation of clathrin-coated vesicles at the plasma membrane. Together, these data indicate that BVDV infection requires an active clathrin-dependent endocytic pathway.</jats:p> Bovine Viral Diarrhea Virus Entry Is Dependent on Clathrin-Mediated Endocytosis Journal of Virology |
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| title |
Bovine Viral Diarrhea Virus Entry Is Dependent on Clathrin-Mediated Endocytosis |
| title_unstemmed |
Bovine Viral Diarrhea Virus Entry Is Dependent on Clathrin-Mediated Endocytosis |
| title_full |
Bovine Viral Diarrhea Virus Entry Is Dependent on Clathrin-Mediated Endocytosis |
| title_fullStr |
Bovine Viral Diarrhea Virus Entry Is Dependent on Clathrin-Mediated Endocytosis |
| title_full_unstemmed |
Bovine Viral Diarrhea Virus Entry Is Dependent on Clathrin-Mediated Endocytosis |
| title_short |
Bovine Viral Diarrhea Virus Entry Is Dependent on Clathrin-Mediated Endocytosis |
| title_sort |
bovine viral diarrhea virus entry is dependent on clathrin-mediated endocytosis |
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Virology Insect Science Immunology Microbiology |
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http://dx.doi.org/10.1128/jvi.79.16.10826-10829.2005 |
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2005 |
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10826-10829 |
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<jats:title>ABSTRACT</jats:title>
<jats:p>Cellular mechanisms of bovine viral diarrhea virus (BVDV) entry in MDBK cells were investigated. Chloroquine, bafilomycin A1, or ammonium chloride inhibited BVDV infection, indicating that an acidic endosomal pH is required for BVDV entry. The tyrosine kinase inhibitor genistein partially inhibited BVDV infection at a postentry step, whereas BVDV entry was strongly inhibited by chlorpromazine or by the overexpression of a dominant-negative form of EPS15, a protein essential for the formation of clathrin-coated vesicles at the plasma membrane. Together, these data indicate that BVDV infection requires an active clathrin-dependent endocytic pathway.</jats:p> |
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| author | Lecot, Steve, Belouzard, Sandrine, Dubuisson, Jean, Rouillé, Yves |
| author_facet | Lecot, Steve, Belouzard, Sandrine, Dubuisson, Jean, Rouillé, Yves, Lecot, Steve, Belouzard, Sandrine, Dubuisson, Jean, Rouillé, Yves |
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| description | <jats:title>ABSTRACT</jats:title> <jats:p>Cellular mechanisms of bovine viral diarrhea virus (BVDV) entry in MDBK cells were investigated. Chloroquine, bafilomycin A1, or ammonium chloride inhibited BVDV infection, indicating that an acidic endosomal pH is required for BVDV entry. The tyrosine kinase inhibitor genistein partially inhibited BVDV infection at a postentry step, whereas BVDV entry was strongly inhibited by chlorpromazine or by the overexpression of a dominant-negative form of EPS15, a protein essential for the formation of clathrin-coated vesicles at the plasma membrane. Together, these data indicate that BVDV infection requires an active clathrin-dependent endocytic pathway.</jats:p> |
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| spelling | Lecot, Steve Belouzard, Sandrine Dubuisson, Jean Rouillé, Yves 0022-538X 1098-5514 American Society for Microbiology Virology Insect Science Immunology Microbiology http://dx.doi.org/10.1128/jvi.79.16.10826-10829.2005 <jats:title>ABSTRACT</jats:title> <jats:p>Cellular mechanisms of bovine viral diarrhea virus (BVDV) entry in MDBK cells were investigated. Chloroquine, bafilomycin A1, or ammonium chloride inhibited BVDV infection, indicating that an acidic endosomal pH is required for BVDV entry. The tyrosine kinase inhibitor genistein partially inhibited BVDV infection at a postentry step, whereas BVDV entry was strongly inhibited by chlorpromazine or by the overexpression of a dominant-negative form of EPS15, a protein essential for the formation of clathrin-coated vesicles at the plasma membrane. Together, these data indicate that BVDV infection requires an active clathrin-dependent endocytic pathway.</jats:p> Bovine Viral Diarrhea Virus Entry Is Dependent on Clathrin-Mediated Endocytosis Journal of Virology |
| spellingShingle | Lecot, Steve, Belouzard, Sandrine, Dubuisson, Jean, Rouillé, Yves, Journal of Virology, Bovine Viral Diarrhea Virus Entry Is Dependent on Clathrin-Mediated Endocytosis, Virology, Insect Science, Immunology, Microbiology |
| title | Bovine Viral Diarrhea Virus Entry Is Dependent on Clathrin-Mediated Endocytosis |
| title_full | Bovine Viral Diarrhea Virus Entry Is Dependent on Clathrin-Mediated Endocytosis |
| title_fullStr | Bovine Viral Diarrhea Virus Entry Is Dependent on Clathrin-Mediated Endocytosis |
| title_full_unstemmed | Bovine Viral Diarrhea Virus Entry Is Dependent on Clathrin-Mediated Endocytosis |
| title_short | Bovine Viral Diarrhea Virus Entry Is Dependent on Clathrin-Mediated Endocytosis |
| title_sort | bovine viral diarrhea virus entry is dependent on clathrin-mediated endocytosis |
| title_unstemmed | Bovine Viral Diarrhea Virus Entry Is Dependent on Clathrin-Mediated Endocytosis |
| topic | Virology, Insect Science, Immunology, Microbiology |
| url | http://dx.doi.org/10.1128/jvi.79.16.10826-10829.2005 |