Eintrag weiter verarbeiten
A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans
Gespeichert in:
| Zeitschriftentitel: | Journal of Virology |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Journal of Virology, 61, 1987, 9, S. 2917-2920 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
|
| Schlagwörter: |
| author_facet |
La Monica, N Almond, J W Racaniello, V R La Monica, N Almond, J W Racaniello, V R |
|---|---|
| author |
La Monica, N Almond, J W Racaniello, V R |
| spellingShingle |
La Monica, N Almond, J W Racaniello, V R Journal of Virology A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans Virology Insect Science Immunology Microbiology |
| author_sort |
la monica, n |
| spelling |
La Monica, N Almond, J W Racaniello, V R 0022-538X 1098-5514 American Society for Microbiology Virology Insect Science Immunology Microbiology http://dx.doi.org/10.1128/jvi.61.9.2917-2920.1987 <jats:p>A mutation in the genome of poliovirus type 3 that is known to reduce neurovirulence in humans similarly reduces neurovirulence in mice when incorporated into a mouse-adapted-human poliovirus recombinant. Viral recombinants with a uracil at nucleotide position 472 in the 5'-noncoding regions of their genomes are unable to replicate in the mouse brain. Viral recombinants with a cytosine at this position are neurovirulent in mice. Neurovirulence of poliovirus in mice may therefore prove to be a useful indicator of the genetic stability of new attenuating mutations created by site-directed mutagenesis.</jats:p> A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans Journal of Virology |
| doi_str_mv |
10.1128/jvi.61.9.2917-2920.1987 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin Biologie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyOC9qdmkuNjEuOS4yOTE3LTI5MjAuMTk4Nw |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyOC9qdmkuNjEuOS4yOTE3LTI5MjAuMTk4Nw |
| institution |
DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 |
| imprint |
American Society for Microbiology, 1987 |
| imprint_str_mv |
American Society for Microbiology, 1987 |
| issn |
0022-538X 1098-5514 |
| issn_str_mv |
0022-538X 1098-5514 |
| language |
English |
| mega_collection |
American Society for Microbiology (CrossRef) |
| match_str |
lamonica1987amousemodelforpoliovirusneurovirulenceidentifiesmutationsthatattenuatethevirusforhumans |
| publishDateSort |
1987 |
| publisher |
American Society for Microbiology |
| recordtype |
ai |
| record_format |
ai |
| series |
Journal of Virology |
| source_id |
49 |
| title |
A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans |
| title_unstemmed |
A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans |
| title_full |
A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans |
| title_fullStr |
A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans |
| title_full_unstemmed |
A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans |
| title_short |
A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans |
| title_sort |
a mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans |
| topic |
Virology Insect Science Immunology Microbiology |
| url |
http://dx.doi.org/10.1128/jvi.61.9.2917-2920.1987 |
| publishDate |
1987 |
| physical |
2917-2920 |
| description |
<jats:p>A mutation in the genome of poliovirus type 3 that is known to reduce neurovirulence in humans similarly reduces neurovirulence in mice when incorporated into a mouse-adapted-human poliovirus recombinant. Viral recombinants with a uracil at nucleotide position 472 in the 5'-noncoding regions of their genomes are unable to replicate in the mouse brain. Viral recombinants with a cytosine at this position are neurovirulent in mice. Neurovirulence of poliovirus in mice may therefore prove to be a useful indicator of the genetic stability of new attenuating mutations created by site-directed mutagenesis.</jats:p> |
| container_issue |
9 |
| container_start_page |
2917 |
| container_title |
Journal of Virology |
| container_volume |
61 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792343176201109508 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T16:47:32.886Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=A+mouse+model+for+poliovirus+neurovirulence+identifies+mutations+that+attenuate+the+virus+for+humans&rft.date=1987-09-01&genre=article&issn=1098-5514&volume=61&issue=9&spage=2917&epage=2920&pages=2917-2920&jtitle=Journal+of+Virology&atitle=A+mouse+model+for+poliovirus+neurovirulence+identifies+mutations+that+attenuate+the+virus+for+humans&aulast=Racaniello&aufirst=V+R&rft_id=info%3Adoi%2F10.1128%2Fjvi.61.9.2917-2920.1987&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792343176201109508 |
| author | La Monica, N, Almond, J W, Racaniello, V R |
| author_facet | La Monica, N, Almond, J W, Racaniello, V R, La Monica, N, Almond, J W, Racaniello, V R |
| author_sort | la monica, n |
| container_issue | 9 |
| container_start_page | 2917 |
| container_title | Journal of Virology |
| container_volume | 61 |
| description | <jats:p>A mutation in the genome of poliovirus type 3 that is known to reduce neurovirulence in humans similarly reduces neurovirulence in mice when incorporated into a mouse-adapted-human poliovirus recombinant. Viral recombinants with a uracil at nucleotide position 472 in the 5'-noncoding regions of their genomes are unable to replicate in the mouse brain. Viral recombinants with a cytosine at this position are neurovirulent in mice. Neurovirulence of poliovirus in mice may therefore prove to be a useful indicator of the genetic stability of new attenuating mutations created by site-directed mutagenesis.</jats:p> |
| doi_str_mv | 10.1128/jvi.61.9.2917-2920.1987 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin, Biologie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyOC9qdmkuNjEuOS4yOTE3LTI5MjAuMTk4Nw |
| imprint | American Society for Microbiology, 1987 |
| imprint_str_mv | American Society for Microbiology, 1987 |
| institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1 |
| issn | 0022-538X, 1098-5514 |
| issn_str_mv | 0022-538X, 1098-5514 |
| language | English |
| last_indexed | 2024-03-01T16:47:32.886Z |
| match_str | lamonica1987amousemodelforpoliovirusneurovirulenceidentifiesmutationsthatattenuatethevirusforhumans |
| mega_collection | American Society for Microbiology (CrossRef) |
| physical | 2917-2920 |
| publishDate | 1987 |
| publishDateSort | 1987 |
| publisher | American Society for Microbiology |
| record_format | ai |
| recordtype | ai |
| series | Journal of Virology |
| source_id | 49 |
| spelling | La Monica, N Almond, J W Racaniello, V R 0022-538X 1098-5514 American Society for Microbiology Virology Insect Science Immunology Microbiology http://dx.doi.org/10.1128/jvi.61.9.2917-2920.1987 <jats:p>A mutation in the genome of poliovirus type 3 that is known to reduce neurovirulence in humans similarly reduces neurovirulence in mice when incorporated into a mouse-adapted-human poliovirus recombinant. Viral recombinants with a uracil at nucleotide position 472 in the 5'-noncoding regions of their genomes are unable to replicate in the mouse brain. Viral recombinants with a cytosine at this position are neurovirulent in mice. Neurovirulence of poliovirus in mice may therefore prove to be a useful indicator of the genetic stability of new attenuating mutations created by site-directed mutagenesis.</jats:p> A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans Journal of Virology |
| spellingShingle | La Monica, N, Almond, J W, Racaniello, V R, Journal of Virology, A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans, Virology, Insect Science, Immunology, Microbiology |
| title | A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans |
| title_full | A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans |
| title_fullStr | A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans |
| title_full_unstemmed | A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans |
| title_short | A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans |
| title_sort | a mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans |
| title_unstemmed | A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans |
| topic | Virology, Insect Science, Immunology, Microbiology |
| url | http://dx.doi.org/10.1128/jvi.61.9.2917-2920.1987 |