A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans

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Bibliographische Detailangaben
Zeitschriftentitel:	Journal of Virology
Personen und Körperschaften:	La Monica, N, Almond, J W, Racaniello, V R
In:	Journal of Virology, 61, 1987, 9, S. 2917-2920
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	American Society for Microbiology
Schlagwörter:	Virology Insect Science Immunology Microbiology

Details
Zusammenfassung:	<jats:p>A mutation in the genome of poliovirus type 3 that is known to reduce neurovirulence in humans similarly reduces neurovirulence in mice when incorporated into a mouse-adapted-human poliovirus recombinant. Viral recombinants with a uracil at nucleotide position 472 in the 5'-noncoding regions of their genomes are unable to replicate in the mouse brain. Viral recombinants with a cytosine at this position are neurovirulent in mice. Neurovirulence of poliovirus in mice may therefore prove to be a useful indicator of the genetic stability of new attenuating mutations created by site-directed mutagenesis.</jats:p>
Umfang:	2917-2920
ISSN:	0022-538X 1098-5514
DOI:	10.1128/jvi.61.9.2917-2920.1987