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Genetic Informational RNA Is Not Required for Recombinant Prion Infectivity
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| Zeitschriftentitel: | Journal of Virology |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Journal of Virology, 86, 2012, 3, S. 1874-1876 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| author_facet |
Wang, Fei Zhang, Zhihong Wang, Xinhe Li, Jiali Zha, Liang Yuan, Chong-Gang Weissmann, Charles Ma, Jiyan Wang, Fei Zhang, Zhihong Wang, Xinhe Li, Jiali Zha, Liang Yuan, Chong-Gang Weissmann, Charles Ma, Jiyan |
|---|---|
| author |
Wang, Fei Zhang, Zhihong Wang, Xinhe Li, Jiali Zha, Liang Yuan, Chong-Gang Weissmann, Charles Ma, Jiyan |
| spellingShingle |
Wang, Fei Zhang, Zhihong Wang, Xinhe Li, Jiali Zha, Liang Yuan, Chong-Gang Weissmann, Charles Ma, Jiyan Journal of Virology Genetic Informational RNA Is Not Required for Recombinant Prion Infectivity Virology Insect Science Immunology Microbiology |
| author_sort |
wang, fei |
| spelling |
Wang, Fei Zhang, Zhihong Wang, Xinhe Li, Jiali Zha, Liang Yuan, Chong-Gang Weissmann, Charles Ma, Jiyan 0022-538X 1098-5514 American Society for Microbiology Virology Insect Science Immunology Microbiology http://dx.doi.org/10.1128/jvi.06216-11 <jats:title>ABSTRACT</jats:title> <jats:p>Whether a genetic informational nucleic acid is required for the infectivity of transmissible spongiform encephalopathies is central to the debate about the infectious agent. Here we report that an infectious prion formed with bacterially expressed recombinant prion protein plus synthetic polyriboadenylic acid and synthetic phospholipid 1-palmitoyl-2-oleoylphosphatidylglycerol is competent to infect cultured cells and cause prion disease in wild-type mice. Our results show that genetic informational RNA is not required for recombinant prion infectivity.</jats:p> Genetic Informational RNA Is Not Required for Recombinant Prion Infectivity Journal of Virology |
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| title |
Genetic Informational RNA Is Not Required for Recombinant Prion Infectivity |
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Genetic Informational RNA Is Not Required for Recombinant Prion Infectivity |
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Genetic Informational RNA Is Not Required for Recombinant Prion Infectivity |
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Genetic Informational RNA Is Not Required for Recombinant Prion Infectivity |
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Genetic Informational RNA Is Not Required for Recombinant Prion Infectivity |
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Genetic Informational RNA Is Not Required for Recombinant Prion Infectivity |
| title_sort |
genetic informational rna is not required for recombinant prion infectivity |
| topic |
Virology Insect Science Immunology Microbiology |
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http://dx.doi.org/10.1128/jvi.06216-11 |
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2012 |
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1874-1876 |
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<jats:title>ABSTRACT</jats:title>
<jats:p>Whether a genetic informational nucleic acid is required for the infectivity of transmissible spongiform encephalopathies is central to the debate about the infectious agent. Here we report that an infectious prion formed with bacterially expressed recombinant prion protein plus synthetic polyriboadenylic acid and synthetic phospholipid 1-palmitoyl-2-oleoylphosphatidylglycerol is competent to infect cultured cells and cause prion disease in wild-type mice. Our results show that genetic informational RNA is not required for recombinant prion infectivity.</jats:p> |
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| author | Wang, Fei, Zhang, Zhihong, Wang, Xinhe, Li, Jiali, Zha, Liang, Yuan, Chong-Gang, Weissmann, Charles, Ma, Jiyan |
| author_facet | Wang, Fei, Zhang, Zhihong, Wang, Xinhe, Li, Jiali, Zha, Liang, Yuan, Chong-Gang, Weissmann, Charles, Ma, Jiyan, Wang, Fei, Zhang, Zhihong, Wang, Xinhe, Li, Jiali, Zha, Liang, Yuan, Chong-Gang, Weissmann, Charles, Ma, Jiyan |
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| description | <jats:title>ABSTRACT</jats:title> <jats:p>Whether a genetic informational nucleic acid is required for the infectivity of transmissible spongiform encephalopathies is central to the debate about the infectious agent. Here we report that an infectious prion formed with bacterially expressed recombinant prion protein plus synthetic polyriboadenylic acid and synthetic phospholipid 1-palmitoyl-2-oleoylphosphatidylglycerol is competent to infect cultured cells and cause prion disease in wild-type mice. Our results show that genetic informational RNA is not required for recombinant prion infectivity.</jats:p> |
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| physical | 1874-1876 |
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| spelling | Wang, Fei Zhang, Zhihong Wang, Xinhe Li, Jiali Zha, Liang Yuan, Chong-Gang Weissmann, Charles Ma, Jiyan 0022-538X 1098-5514 American Society for Microbiology Virology Insect Science Immunology Microbiology http://dx.doi.org/10.1128/jvi.06216-11 <jats:title>ABSTRACT</jats:title> <jats:p>Whether a genetic informational nucleic acid is required for the infectivity of transmissible spongiform encephalopathies is central to the debate about the infectious agent. Here we report that an infectious prion formed with bacterially expressed recombinant prion protein plus synthetic polyriboadenylic acid and synthetic phospholipid 1-palmitoyl-2-oleoylphosphatidylglycerol is competent to infect cultured cells and cause prion disease in wild-type mice. Our results show that genetic informational RNA is not required for recombinant prion infectivity.</jats:p> Genetic Informational RNA Is Not Required for Recombinant Prion Infectivity Journal of Virology |
| spellingShingle | Wang, Fei, Zhang, Zhihong, Wang, Xinhe, Li, Jiali, Zha, Liang, Yuan, Chong-Gang, Weissmann, Charles, Ma, Jiyan, Journal of Virology, Genetic Informational RNA Is Not Required for Recombinant Prion Infectivity, Virology, Insect Science, Immunology, Microbiology |
| title | Genetic Informational RNA Is Not Required for Recombinant Prion Infectivity |
| title_full | Genetic Informational RNA Is Not Required for Recombinant Prion Infectivity |
| title_fullStr | Genetic Informational RNA Is Not Required for Recombinant Prion Infectivity |
| title_full_unstemmed | Genetic Informational RNA Is Not Required for Recombinant Prion Infectivity |
| title_short | Genetic Informational RNA Is Not Required for Recombinant Prion Infectivity |
| title_sort | genetic informational rna is not required for recombinant prion infectivity |
| title_unstemmed | Genetic Informational RNA Is Not Required for Recombinant Prion Infectivity |
| topic | Virology, Insect Science, Immunology, Microbiology |
| url | http://dx.doi.org/10.1128/jvi.06216-11 |