Genetic Informational RNA Is Not Required for Recombinant Prion Infectivity

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Bibliographische Detailangaben
Zeitschriftentitel:	Journal of Virology
Personen und Körperschaften:	Wang, Fei, Zhang, Zhihong, Wang, Xinhe, Li, Jiali, Zha, Liang, Yuan, Chong-Gang, Weissmann, Charles, Ma, Jiyan
In:	Journal of Virology, 86, 2012, 3, S. 1874-1876
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	American Society for Microbiology
Schlagwörter:	Virology Insect Science Immunology Microbiology

Details
Zusammenfassung:	<jats:title>ABSTRACT</jats:title> <jats:p>Whether a genetic informational nucleic acid is required for the infectivity of transmissible spongiform encephalopathies is central to the debate about the infectious agent. Here we report that an infectious prion formed with bacterially expressed recombinant prion protein plus synthetic polyriboadenylic acid and synthetic phospholipid 1-palmitoyl-2-oleoylphosphatidylglycerol is competent to infect cultured cells and cause prion disease in wild-type mice. Our results show that genetic informational RNA is not required for recombinant prion infectivity.</jats:p>
Umfang:	1874-1876
ISSN:	0022-538X 1098-5514
DOI:	10.1128/jvi.06216-11