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Cottontail Rabbit Papillomavirus E1 and E2 Proteins Mutually Influence Their Subcellular Localizations
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| Zeitschriftentitel: | Journal of Virology |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Journal of Virology, 92, 2018, 21 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
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Schneider, Markus Yigitliler, Aylin Stubenrauch, Frank Iftner, Thomas Schneider, Markus Yigitliler, Aylin Stubenrauch, Frank Iftner, Thomas |
|---|---|
| author |
Schneider, Markus Yigitliler, Aylin Stubenrauch, Frank Iftner, Thomas |
| spellingShingle |
Schneider, Markus Yigitliler, Aylin Stubenrauch, Frank Iftner, Thomas Journal of Virology Cottontail Rabbit Papillomavirus E1 and E2 Proteins Mutually Influence Their Subcellular Localizations Virology Insect Science Immunology Microbiology |
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schneider, markus |
| spelling |
Schneider, Markus Yigitliler, Aylin Stubenrauch, Frank Iftner, Thomas 0022-538X 1098-5514 American Society for Microbiology Virology Insect Science Immunology Microbiology http://dx.doi.org/10.1128/jvi.00704-18 <jats:p>Papillomaviruses encode the DNA-binding E1 and E2 proteins, which form a complex and are essential for genome replication. Both proteins are targeted to the nucleus via nuclear localization signals. Our studies have uncovered that cytoplasmic mutant E1 or E2 proteins can be localized to the nucleus when E1 or E2 is also present. An interaction between E1 and E2 is necessary to target cytoplasmic E1 mutant proteins to the nucleus, but cytoplasmic E2 mutant proteins can be targeted to the nucleus without a direct interaction, which points to a novel function of E1.</jats:p> Cottontail Rabbit Papillomavirus E1 and E2 Proteins Mutually Influence Their Subcellular Localizations Journal of Virology |
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American Society for Microbiology, 2018 |
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| title |
Cottontail Rabbit Papillomavirus E1 and E2 Proteins Mutually Influence Their Subcellular Localizations |
| title_unstemmed |
Cottontail Rabbit Papillomavirus E1 and E2 Proteins Mutually Influence Their Subcellular Localizations |
| title_full |
Cottontail Rabbit Papillomavirus E1 and E2 Proteins Mutually Influence Their Subcellular Localizations |
| title_fullStr |
Cottontail Rabbit Papillomavirus E1 and E2 Proteins Mutually Influence Their Subcellular Localizations |
| title_full_unstemmed |
Cottontail Rabbit Papillomavirus E1 and E2 Proteins Mutually Influence Their Subcellular Localizations |
| title_short |
Cottontail Rabbit Papillomavirus E1 and E2 Proteins Mutually Influence Their Subcellular Localizations |
| title_sort |
cottontail rabbit papillomavirus e1 and e2 proteins mutually influence their subcellular localizations |
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Virology Insect Science Immunology Microbiology |
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http://dx.doi.org/10.1128/jvi.00704-18 |
| publishDate |
2018 |
| physical |
|
| description |
<jats:p>Papillomaviruses encode the DNA-binding E1 and E2 proteins, which form a complex and are essential for genome replication. Both proteins are targeted to the nucleus via nuclear localization signals. Our studies have uncovered that cytoplasmic mutant E1 or E2 proteins can be localized to the nucleus when E1 or E2 is also present. An interaction between E1 and E2 is necessary to target cytoplasmic E1 mutant proteins to the nucleus, but cytoplasmic E2 mutant proteins can be targeted to the nucleus without a direct interaction, which points to a novel function of E1.</jats:p> |
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| author | Schneider, Markus, Yigitliler, Aylin, Stubenrauch, Frank, Iftner, Thomas |
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| description | <jats:p>Papillomaviruses encode the DNA-binding E1 and E2 proteins, which form a complex and are essential for genome replication. Both proteins are targeted to the nucleus via nuclear localization signals. Our studies have uncovered that cytoplasmic mutant E1 or E2 proteins can be localized to the nucleus when E1 or E2 is also present. An interaction between E1 and E2 is necessary to target cytoplasmic E1 mutant proteins to the nucleus, but cytoplasmic E2 mutant proteins can be targeted to the nucleus without a direct interaction, which points to a novel function of E1.</jats:p> |
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| spelling | Schneider, Markus Yigitliler, Aylin Stubenrauch, Frank Iftner, Thomas 0022-538X 1098-5514 American Society for Microbiology Virology Insect Science Immunology Microbiology http://dx.doi.org/10.1128/jvi.00704-18 <jats:p>Papillomaviruses encode the DNA-binding E1 and E2 proteins, which form a complex and are essential for genome replication. Both proteins are targeted to the nucleus via nuclear localization signals. Our studies have uncovered that cytoplasmic mutant E1 or E2 proteins can be localized to the nucleus when E1 or E2 is also present. An interaction between E1 and E2 is necessary to target cytoplasmic E1 mutant proteins to the nucleus, but cytoplasmic E2 mutant proteins can be targeted to the nucleus without a direct interaction, which points to a novel function of E1.</jats:p> Cottontail Rabbit Papillomavirus E1 and E2 Proteins Mutually Influence Their Subcellular Localizations Journal of Virology |
| spellingShingle | Schneider, Markus, Yigitliler, Aylin, Stubenrauch, Frank, Iftner, Thomas, Journal of Virology, Cottontail Rabbit Papillomavirus E1 and E2 Proteins Mutually Influence Their Subcellular Localizations, Virology, Insect Science, Immunology, Microbiology |
| title | Cottontail Rabbit Papillomavirus E1 and E2 Proteins Mutually Influence Their Subcellular Localizations |
| title_full | Cottontail Rabbit Papillomavirus E1 and E2 Proteins Mutually Influence Their Subcellular Localizations |
| title_fullStr | Cottontail Rabbit Papillomavirus E1 and E2 Proteins Mutually Influence Their Subcellular Localizations |
| title_full_unstemmed | Cottontail Rabbit Papillomavirus E1 and E2 Proteins Mutually Influence Their Subcellular Localizations |
| title_short | Cottontail Rabbit Papillomavirus E1 and E2 Proteins Mutually Influence Their Subcellular Localizations |
| title_sort | cottontail rabbit papillomavirus e1 and e2 proteins mutually influence their subcellular localizations |
| title_unstemmed | Cottontail Rabbit Papillomavirus E1 and E2 Proteins Mutually Influence Their Subcellular Localizations |
| topic | Virology, Insect Science, Immunology, Microbiology |
| url | http://dx.doi.org/10.1128/jvi.00704-18 |