Cottontail Rabbit Papillomavirus E1 and E2 Proteins Mutually Influence Their Subcellular Localizations

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Bibliographische Detailangaben
Zeitschriftentitel:	Journal of Virology
Personen und Körperschaften:	Schneider, Markus, Yigitliler, Aylin, Stubenrauch, Frank, Iftner, Thomas
In:	Journal of Virology, 92, 2018, 21
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	American Society for Microbiology
Schlagwörter:	Virology Insect Science Immunology Microbiology

Details
Zusammenfassung:	<jats:p>Papillomaviruses encode the DNA-binding E1 and E2 proteins, which form a complex and are essential for genome replication. Both proteins are targeted to the nucleus via nuclear localization signals. Our studies have uncovered that cytoplasmic mutant E1 or E2 proteins can be localized to the nucleus when E1 or E2 is also present. An interaction between E1 and E2 is necessary to target cytoplasmic E1 mutant proteins to the nucleus, but cytoplasmic E2 mutant proteins can be targeted to the nucleus without a direct interaction, which points to a novel function of E1.</jats:p>
ISSN:	0022-538X 1098-5514
DOI:	10.1128/jvi.00704-18