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Evolutionary relationships among extradiol dioxygenases
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| Zeitschriftentitel: | Journal of Bacteriology |
|---|---|
| Personen und Körperschaften: | , |
| In: | Journal of Bacteriology, 178, 1996, 20, S. 5930-5937 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
|
| Schlagwörter: |
| author_facet |
Eltis, L D Bolin, J T Eltis, L D Bolin, J T |
|---|---|
| author |
Eltis, L D Bolin, J T |
| spellingShingle |
Eltis, L D Bolin, J T Journal of Bacteriology Evolutionary relationships among extradiol dioxygenases Molecular Biology Microbiology |
| author_sort |
eltis, l d |
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Eltis, L D Bolin, J T 0021-9193 1098-5530 American Society for Microbiology Molecular Biology Microbiology http://dx.doi.org/10.1128/jb.178.20.5930-5937.1996 <jats:p>A structure-validated alignment of 35 extradiol dioxygenase sequences including two-domain and one-domain enzymes was derived. Strictly conserved residues include the metal ion ligands and several catalytically essential active site residues, as well as a number of structurally important residues that are remote from the active site. Phylogenetic analyses based on this alignment indicate that the ancestral extradiol dioxygenase was a one-domain enzyme and that the two-domain enzymes arose from a single genetic duplication event. Subsequent divergence among the two-domain dioxygenases has resulted in several families, two of which are based on substrate preference. In several cases, the two domains of a given enzyme express different phylogenies, suggesting the possibility that such enzymes arose from the recombination of genes encoding different dioxygenases. A phylogeny-based classification system for extradiol dioxygenases is proposed.</jats:p> Evolutionary relationships among extradiol dioxygenases Journal of Bacteriology |
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| title |
Evolutionary relationships among extradiol dioxygenases |
| title_unstemmed |
Evolutionary relationships among extradiol dioxygenases |
| title_full |
Evolutionary relationships among extradiol dioxygenases |
| title_fullStr |
Evolutionary relationships among extradiol dioxygenases |
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Evolutionary relationships among extradiol dioxygenases |
| title_short |
Evolutionary relationships among extradiol dioxygenases |
| title_sort |
evolutionary relationships among extradiol dioxygenases |
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Molecular Biology Microbiology |
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http://dx.doi.org/10.1128/jb.178.20.5930-5937.1996 |
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5930-5937 |
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<jats:p>A structure-validated alignment of 35 extradiol dioxygenase sequences including two-domain and one-domain enzymes was derived. Strictly conserved residues include the metal ion ligands and several catalytically essential active site residues, as well as a number of structurally important residues that are remote from the active site. Phylogenetic analyses based on this alignment indicate that the ancestral extradiol dioxygenase was a one-domain enzyme and that the two-domain enzymes arose from a single genetic duplication event. Subsequent divergence among the two-domain dioxygenases has resulted in several families, two of which are based on substrate preference. In several cases, the two domains of a given enzyme express different phylogenies, suggesting the possibility that such enzymes arose from the recombination of genes encoding different dioxygenases. A phylogeny-based classification system for extradiol dioxygenases is proposed.</jats:p> |
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| description | <jats:p>A structure-validated alignment of 35 extradiol dioxygenase sequences including two-domain and one-domain enzymes was derived. Strictly conserved residues include the metal ion ligands and several catalytically essential active site residues, as well as a number of structurally important residues that are remote from the active site. Phylogenetic analyses based on this alignment indicate that the ancestral extradiol dioxygenase was a one-domain enzyme and that the two-domain enzymes arose from a single genetic duplication event. Subsequent divergence among the two-domain dioxygenases has resulted in several families, two of which are based on substrate preference. In several cases, the two domains of a given enzyme express different phylogenies, suggesting the possibility that such enzymes arose from the recombination of genes encoding different dioxygenases. A phylogeny-based classification system for extradiol dioxygenases is proposed.</jats:p> |
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| imprint | American Society for Microbiology, 1996 |
| imprint_str_mv | American Society for Microbiology, 1996 |
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| spelling | Eltis, L D Bolin, J T 0021-9193 1098-5530 American Society for Microbiology Molecular Biology Microbiology http://dx.doi.org/10.1128/jb.178.20.5930-5937.1996 <jats:p>A structure-validated alignment of 35 extradiol dioxygenase sequences including two-domain and one-domain enzymes was derived. Strictly conserved residues include the metal ion ligands and several catalytically essential active site residues, as well as a number of structurally important residues that are remote from the active site. Phylogenetic analyses based on this alignment indicate that the ancestral extradiol dioxygenase was a one-domain enzyme and that the two-domain enzymes arose from a single genetic duplication event. Subsequent divergence among the two-domain dioxygenases has resulted in several families, two of which are based on substrate preference. In several cases, the two domains of a given enzyme express different phylogenies, suggesting the possibility that such enzymes arose from the recombination of genes encoding different dioxygenases. A phylogeny-based classification system for extradiol dioxygenases is proposed.</jats:p> Evolutionary relationships among extradiol dioxygenases Journal of Bacteriology |
| spellingShingle | Eltis, L D, Bolin, J T, Journal of Bacteriology, Evolutionary relationships among extradiol dioxygenases, Molecular Biology, Microbiology |
| title | Evolutionary relationships among extradiol dioxygenases |
| title_full | Evolutionary relationships among extradiol dioxygenases |
| title_fullStr | Evolutionary relationships among extradiol dioxygenases |
| title_full_unstemmed | Evolutionary relationships among extradiol dioxygenases |
| title_short | Evolutionary relationships among extradiol dioxygenases |
| title_sort | evolutionary relationships among extradiol dioxygenases |
| title_unstemmed | Evolutionary relationships among extradiol dioxygenases |
| topic | Molecular Biology, Microbiology |
| url | http://dx.doi.org/10.1128/jb.178.20.5930-5937.1996 |