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Protein Serine/Threonine Kinase StkP Positively Controls Virulence and Competence in Streptococcus pneumoniae
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| Zeitschriftentitel: | Infection and Immunity |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Infection and Immunity, 72, 2004, 4, S. 2434-2437 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
|
| Schlagwörter: |
| author_facet |
Echenique, Jose Kadioglu, Aras Romao, Susana Andrew, Peter W. Trombe, Marie-Claude Echenique, Jose Kadioglu, Aras Romao, Susana Andrew, Peter W. Trombe, Marie-Claude |
|---|---|
| author |
Echenique, Jose Kadioglu, Aras Romao, Susana Andrew, Peter W. Trombe, Marie-Claude |
| spellingShingle |
Echenique, Jose Kadioglu, Aras Romao, Susana Andrew, Peter W. Trombe, Marie-Claude Infection and Immunity Protein Serine/Threonine Kinase StkP Positively Controls Virulence and Competence in Streptococcus pneumoniae Infectious Diseases Immunology Microbiology Parasitology |
| author_sort |
echenique, jose |
| spelling |
Echenique, Jose Kadioglu, Aras Romao, Susana Andrew, Peter W. Trombe, Marie-Claude 0019-9567 1098-5522 American Society for Microbiology Infectious Diseases Immunology Microbiology Parasitology http://dx.doi.org/10.1128/iai.72.4.2434-2437.2004 <jats:title>ABSTRACT</jats:title> <jats:p> In the <jats:italic>Streptococcus pneumoniae</jats:italic> genome, <jats:italic>stkP</jats:italic> , encoding a membrane-associated serine/threonine kinase, is not redundant (L. Novakova, S. Romao, J. Echenique, P. Branny, and M.-C. Trombe, unpublished results). The data presented here demonstrate that StkP belongs to the signaling network involved in competence triggering in vitro and lung infection and bloodstream invasion in vivo. In competence, functional StkP is required for activation of <jats:italic>comCDE</jats:italic> upstream of the autoregulated ring orchestrated by the competence-stimulating peptide. This is the first description of positive regulation of <jats:italic>comCDE</jats:italic> transcription in balance with its repression by CiaRH. </jats:p> Protein Serine/Threonine Kinase StkP Positively Controls Virulence and Competence in <i>Streptococcus pneumoniae</i> Infection and Immunity |
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10.1128/iai.72.4.2434-2437.2004 |
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American Society for Microbiology, 2004 |
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American Society for Microbiology, 2004 |
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0019-9567 1098-5522 |
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| title |
Protein Serine/Threonine Kinase StkP Positively Controls Virulence and Competence in Streptococcus pneumoniae |
| title_unstemmed |
Protein Serine/Threonine Kinase StkP Positively Controls Virulence and Competence in Streptococcus pneumoniae |
| title_full |
Protein Serine/Threonine Kinase StkP Positively Controls Virulence and Competence in Streptococcus pneumoniae |
| title_fullStr |
Protein Serine/Threonine Kinase StkP Positively Controls Virulence and Competence in Streptococcus pneumoniae |
| title_full_unstemmed |
Protein Serine/Threonine Kinase StkP Positively Controls Virulence and Competence in Streptococcus pneumoniae |
| title_short |
Protein Serine/Threonine Kinase StkP Positively Controls Virulence and Competence in Streptococcus pneumoniae |
| title_sort |
protein serine/threonine kinase stkp positively controls virulence and competence in
<i>streptococcus pneumoniae</i> |
| topic |
Infectious Diseases Immunology Microbiology Parasitology |
| url |
http://dx.doi.org/10.1128/iai.72.4.2434-2437.2004 |
| publishDate |
2004 |
| physical |
2434-2437 |
| description |
<jats:title>ABSTRACT</jats:title>
<jats:p>
In the
<jats:italic>Streptococcus pneumoniae</jats:italic>
genome,
<jats:italic>stkP</jats:italic>
, encoding a membrane-associated serine/threonine kinase, is not redundant (L. Novakova, S. Romao, J. Echenique, P. Branny, and M.-C. Trombe, unpublished results). The data presented here demonstrate that StkP belongs to the signaling network involved in competence triggering in vitro and lung infection and bloodstream invasion in vivo. In competence, functional StkP is required for activation of
<jats:italic>comCDE</jats:italic>
upstream of the autoregulated ring orchestrated by the competence-stimulating peptide. This is the first description of positive regulation of
<jats:italic>comCDE</jats:italic>
transcription in balance with its repression by CiaRH.
</jats:p> |
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| author | Echenique, Jose, Kadioglu, Aras, Romao, Susana, Andrew, Peter W., Trombe, Marie-Claude |
| author_facet | Echenique, Jose, Kadioglu, Aras, Romao, Susana, Andrew, Peter W., Trombe, Marie-Claude, Echenique, Jose, Kadioglu, Aras, Romao, Susana, Andrew, Peter W., Trombe, Marie-Claude |
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| description | <jats:title>ABSTRACT</jats:title> <jats:p> In the <jats:italic>Streptococcus pneumoniae</jats:italic> genome, <jats:italic>stkP</jats:italic> , encoding a membrane-associated serine/threonine kinase, is not redundant (L. Novakova, S. Romao, J. Echenique, P. Branny, and M.-C. Trombe, unpublished results). The data presented here demonstrate that StkP belongs to the signaling network involved in competence triggering in vitro and lung infection and bloodstream invasion in vivo. In competence, functional StkP is required for activation of <jats:italic>comCDE</jats:italic> upstream of the autoregulated ring orchestrated by the competence-stimulating peptide. This is the first description of positive regulation of <jats:italic>comCDE</jats:italic> transcription in balance with its repression by CiaRH. </jats:p> |
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| imprint | American Society for Microbiology, 2004 |
| imprint_str_mv | American Society for Microbiology, 2004 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, FID-BBI-DE-23, DE-105, DE-14, DE-Ch1, DE-L229 |
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| spelling | Echenique, Jose Kadioglu, Aras Romao, Susana Andrew, Peter W. Trombe, Marie-Claude 0019-9567 1098-5522 American Society for Microbiology Infectious Diseases Immunology Microbiology Parasitology http://dx.doi.org/10.1128/iai.72.4.2434-2437.2004 <jats:title>ABSTRACT</jats:title> <jats:p> In the <jats:italic>Streptococcus pneumoniae</jats:italic> genome, <jats:italic>stkP</jats:italic> , encoding a membrane-associated serine/threonine kinase, is not redundant (L. Novakova, S. Romao, J. Echenique, P. Branny, and M.-C. Trombe, unpublished results). The data presented here demonstrate that StkP belongs to the signaling network involved in competence triggering in vitro and lung infection and bloodstream invasion in vivo. In competence, functional StkP is required for activation of <jats:italic>comCDE</jats:italic> upstream of the autoregulated ring orchestrated by the competence-stimulating peptide. This is the first description of positive regulation of <jats:italic>comCDE</jats:italic> transcription in balance with its repression by CiaRH. </jats:p> Protein Serine/Threonine Kinase StkP Positively Controls Virulence and Competence in <i>Streptococcus pneumoniae</i> Infection and Immunity |
| spellingShingle | Echenique, Jose, Kadioglu, Aras, Romao, Susana, Andrew, Peter W., Trombe, Marie-Claude, Infection and Immunity, Protein Serine/Threonine Kinase StkP Positively Controls Virulence and Competence in Streptococcus pneumoniae, Infectious Diseases, Immunology, Microbiology, Parasitology |
| title | Protein Serine/Threonine Kinase StkP Positively Controls Virulence and Competence in Streptococcus pneumoniae |
| title_full | Protein Serine/Threonine Kinase StkP Positively Controls Virulence and Competence in Streptococcus pneumoniae |
| title_fullStr | Protein Serine/Threonine Kinase StkP Positively Controls Virulence and Competence in Streptococcus pneumoniae |
| title_full_unstemmed | Protein Serine/Threonine Kinase StkP Positively Controls Virulence and Competence in Streptococcus pneumoniae |
| title_short | Protein Serine/Threonine Kinase StkP Positively Controls Virulence and Competence in Streptococcus pneumoniae |
| title_sort | protein serine/threonine kinase stkp positively controls virulence and competence in <i>streptococcus pneumoniae</i> |
| title_unstemmed | Protein Serine/Threonine Kinase StkP Positively Controls Virulence and Competence in Streptococcus pneumoniae |
| topic | Infectious Diseases, Immunology, Microbiology, Parasitology |
| url | http://dx.doi.org/10.1128/iai.72.4.2434-2437.2004 |