Protein Serine/Threonine Kinase StkP Positively Controls Virulence and Competence in Streptococcus pneumoniae

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Bibliographische Detailangaben
Zeitschriftentitel:	Infection and Immunity
Personen und Körperschaften:	Echenique, Jose, Kadioglu, Aras, Romao, Susana, Andrew, Peter W., Trombe, Marie-Claude
In:	Infection and Immunity, 72, 2004, 4, S. 2434-2437
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	American Society for Microbiology
Schlagwörter:	Infectious Diseases Immunology Microbiology Parasitology

Details
Zusammenfassung:	<jats:title>ABSTRACT</jats:title> <jats:p> In the <jats:italic>Streptococcus pneumoniae</jats:italic> genome, <jats:italic>stkP</jats:italic> , encoding a membrane-associated serine/threonine kinase, is not redundant (L. Novakova, S. Romao, J. Echenique, P. Branny, and M.-C. Trombe, unpublished results). The data presented here demonstrate that StkP belongs to the signaling network involved in competence triggering in vitro and lung infection and bloodstream invasion in vivo. In competence, functional StkP is required for activation of <jats:italic>comCDE</jats:italic> upstream of the autoregulated ring orchestrated by the competence-stimulating peptide. This is the first description of positive regulation of <jats:italic>comCDE</jats:italic> transcription in balance with its repression by CiaRH. </jats:p>
Umfang:	2434-2437
ISSN:	0019-9567 1098-5522
DOI:	10.1128/iai.72.4.2434-2437.2004