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Francisella tularensisInduces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication
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| Zeitschriftentitel: | Infection and Immunity |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Infection and Immunity, 69, 2001, 7, S. 4691-4694 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| author_facet |
Lai, Xin-He Golovliov, Igor Sjöstedt, Anders Lai, Xin-He Golovliov, Igor Sjöstedt, Anders |
|---|---|
| author |
Lai, Xin-He Golovliov, Igor Sjöstedt, Anders |
| spellingShingle |
Lai, Xin-He Golovliov, Igor Sjöstedt, Anders Infection and Immunity Francisella tularensisInduces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication Infectious Diseases Immunology Microbiology Parasitology |
| author_sort |
lai, xin-he |
| spelling |
Lai, Xin-He Golovliov, Igor Sjöstedt, Anders 0019-9567 1098-5522 American Society for Microbiology Infectious Diseases Immunology Microbiology Parasitology http://dx.doi.org/10.1128/iai.69.7.4691-4694.2001 <jats:title>ABSTRACT</jats:title><jats:p>The murine macrophage-like cell line J774.A1 ingests and allows intracellular growth of<jats:italic>Francisella tularensis</jats:italic>. We demonstrate that, after 24 h of infection, a pronounced cytopathogenicity resulted and the J774 cells were undergoing apoptosis. Despite this host cell apoptosis, no decrease in bacterial numbers was observed. When internalization of bacteria was prevented or intracellularly located<jats:italic>F. tularensis</jats:italic>bacteria were eradicated within 12 h, the progression of host cell cytopathogenicity and apoptosis was prevented.</jats:p> <i>Francisella tularensis</i>Induces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication Infection and Immunity |
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10.1128/iai.69.7.4691-4694.2001 |
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American Society for Microbiology, 2001 |
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| title |
Francisella tularensisInduces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication |
| title_unstemmed |
Francisella tularensisInduces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication |
| title_full |
Francisella tularensisInduces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication |
| title_fullStr |
Francisella tularensisInduces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication |
| title_full_unstemmed |
Francisella tularensisInduces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication |
| title_short |
Francisella tularensisInduces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication |
| title_sort |
<i>francisella tularensis</i>induces cytopathogenicity and apoptosis in murine macrophages via a mechanism that requires intracellular bacterial multiplication |
| topic |
Infectious Diseases Immunology Microbiology Parasitology |
| url |
http://dx.doi.org/10.1128/iai.69.7.4691-4694.2001 |
| publishDate |
2001 |
| physical |
4691-4694 |
| description |
<jats:title>ABSTRACT</jats:title><jats:p>The murine macrophage-like cell line J774.A1 ingests and allows intracellular growth of<jats:italic>Francisella tularensis</jats:italic>. We demonstrate that, after 24 h of infection, a pronounced cytopathogenicity resulted and the J774 cells were undergoing apoptosis. Despite this host cell apoptosis, no decrease in bacterial numbers was observed. When internalization of bacteria was prevented or intracellularly located<jats:italic>F. tularensis</jats:italic>bacteria were eradicated within 12 h, the progression of host cell cytopathogenicity and apoptosis was prevented.</jats:p> |
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| description | <jats:title>ABSTRACT</jats:title><jats:p>The murine macrophage-like cell line J774.A1 ingests and allows intracellular growth of<jats:italic>Francisella tularensis</jats:italic>. We demonstrate that, after 24 h of infection, a pronounced cytopathogenicity resulted and the J774 cells were undergoing apoptosis. Despite this host cell apoptosis, no decrease in bacterial numbers was observed. When internalization of bacteria was prevented or intracellularly located<jats:italic>F. tularensis</jats:italic>bacteria were eradicated within 12 h, the progression of host cell cytopathogenicity and apoptosis was prevented.</jats:p> |
| doi_str_mv | 10.1128/iai.69.7.4691-4694.2001 |
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| imprint_str_mv | American Society for Microbiology, 2001 |
| institution | DE-Pl11, DE-Rs1, FID-BBI-DE-23, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15 |
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| physical | 4691-4694 |
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| spelling | Lai, Xin-He Golovliov, Igor Sjöstedt, Anders 0019-9567 1098-5522 American Society for Microbiology Infectious Diseases Immunology Microbiology Parasitology http://dx.doi.org/10.1128/iai.69.7.4691-4694.2001 <jats:title>ABSTRACT</jats:title><jats:p>The murine macrophage-like cell line J774.A1 ingests and allows intracellular growth of<jats:italic>Francisella tularensis</jats:italic>. We demonstrate that, after 24 h of infection, a pronounced cytopathogenicity resulted and the J774 cells were undergoing apoptosis. Despite this host cell apoptosis, no decrease in bacterial numbers was observed. When internalization of bacteria was prevented or intracellularly located<jats:italic>F. tularensis</jats:italic>bacteria were eradicated within 12 h, the progression of host cell cytopathogenicity and apoptosis was prevented.</jats:p> <i>Francisella tularensis</i>Induces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication Infection and Immunity |
| spellingShingle | Lai, Xin-He, Golovliov, Igor, Sjöstedt, Anders, Infection and Immunity, Francisella tularensisInduces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication, Infectious Diseases, Immunology, Microbiology, Parasitology |
| title | Francisella tularensisInduces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication |
| title_full | Francisella tularensisInduces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication |
| title_fullStr | Francisella tularensisInduces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication |
| title_full_unstemmed | Francisella tularensisInduces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication |
| title_short | Francisella tularensisInduces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication |
| title_sort | <i>francisella tularensis</i>induces cytopathogenicity and apoptosis in murine macrophages via a mechanism that requires intracellular bacterial multiplication |
| title_unstemmed | Francisella tularensisInduces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication |
| topic | Infectious Diseases, Immunology, Microbiology, Parasitology |
| url | http://dx.doi.org/10.1128/iai.69.7.4691-4694.2001 |