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Francisella tularensisInduces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication
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| Zeitschriftentitel: | Infection and Immunity |
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| Personen und Körperschaften: | , , |
| In: | Infection and Immunity, 69, 2001, 7, S. 4691-4694 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| Zusammenfassung: | <jats:title>ABSTRACT</jats:title><jats:p>The murine macrophage-like cell line J774.A1 ingests and allows intracellular growth of<jats:italic>Francisella tularensis</jats:italic>. We demonstrate that, after 24 h of infection, a pronounced cytopathogenicity resulted and the J774 cells were undergoing apoptosis. Despite this host cell apoptosis, no decrease in bacterial numbers was observed. When internalization of bacteria was prevented or intracellularly located<jats:italic>F. tularensis</jats:italic>bacteria were eradicated within 12 h, the progression of host cell cytopathogenicity and apoptosis was prevented.</jats:p> |
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| Umfang: | 4691-4694 |
| ISSN: |
0019-9567
1098-5522 |
| DOI: | 10.1128/iai.69.7.4691-4694.2001 |