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Interactions ofNeisseria gonorrhoeaewith Mature Human Macrophage Opacity Proteins Influence Production of Proinflammatory Cytokines
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| Zeitschriftentitel: | Infection and Immunity |
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| Personen und Körperschaften: | , , , |
| In: | Infection and Immunity, 69, 2001, 3, S. 1909-1913 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| Zusammenfassung: | <jats:title>ABSTRACT</jats:title><jats:p>The pathological features of ascending gonococcal infection suggest that proinflammatory mediators secreted by tissue-resident macrophages are important components of the host response. Challenge of fully differentiated, mature macrophages with variants of<jats:italic>Neisseria gonorrhoeae</jats:italic>strain P9 or purified bacterial surface components (pili, lipooligosaccharide, and outer membrane vesicles) induced the secretion of interleukin 6 (IL-6), tumor necrosis factor alpha, growth-related protein α, macrophage inflammatory protein 1α (MIP-1α), and RANTES cytokines but had no effect on IL-8 production. No secretion of IL-1β, epithelial-derived neutrophil attractant 78, granulocyte-macrophage colony-stimulating factor, IL-10, or IL-12 cytokines was observed. Notably, the P9-Opa<jats:sub>b</jats:sub>protein, in comparison to P9-Opa<jats:sub>a</jats:sub>, increased the association of gonococci with macrophages and elevated the secretion of cytokines. Thus, variation in Opa protein expression by the gonococcus may be a determining factor in the severity of pelvic inflammatory disease.</jats:p> |
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| Umfang: | 1909-1913 |
| ISSN: |
0019-9567
1098-5522 |
| DOI: | 10.1128/iai.69.3.1909-1913.2001 |