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Efficacy of Telavancin against Penicillin-Resistant Pneumococci and Staphylococcus aureus in a Rabbit Meningitis Model and Determination of Kinetic Parameters
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| Zeitschriftentitel: | Antimicrobial Agents and Chemotherapy |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Antimicrobial Agents and Chemotherapy, 50, 2006, 2, S. 770-773 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
|
| Schlagwörter: |
| author_facet |
Stucki, Armin Gerber, Peter Acosta, Fernando Cottagnoud, Marianne Cottagnoud, Philippe Stucki, Armin Gerber, Peter Acosta, Fernando Cottagnoud, Marianne Cottagnoud, Philippe |
|---|---|
| author |
Stucki, Armin Gerber, Peter Acosta, Fernando Cottagnoud, Marianne Cottagnoud, Philippe |
| spellingShingle |
Stucki, Armin Gerber, Peter Acosta, Fernando Cottagnoud, Marianne Cottagnoud, Philippe Antimicrobial Agents and Chemotherapy Efficacy of Telavancin against Penicillin-Resistant Pneumococci and Staphylococcus aureus in a Rabbit Meningitis Model and Determination of Kinetic Parameters Infectious Diseases Pharmacology (medical) Pharmacology |
| author_sort |
stucki, armin |
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Stucki, Armin Gerber, Peter Acosta, Fernando Cottagnoud, Marianne Cottagnoud, Philippe 0066-4804 1098-6596 American Society for Microbiology Infectious Diseases Pharmacology (medical) Pharmacology http://dx.doi.org/10.1128/aac.50.2.770-773.2006 <jats:title>ABSTRACT</jats:title> <jats:p>The penetration of telavancin was 2% into inflamed meninges and ca. 1‰ into noninflamed meninges after two intravenous injections (30 mg/kg of body weight). In experimental meningitis, telavancin was significantly superior to vancomycin combined with ceftriaxone against a penicillin-resistant pneumococcal strain. Against a methicillin-sensitive staphylococcal strain, telavancin was slightly but not significantly superior to vancomycin.</jats:p> Efficacy of Telavancin against Penicillin-Resistant Pneumococci and <i>Staphylococcus aureus</i> in a Rabbit Meningitis Model and Determination of Kinetic Parameters Antimicrobial Agents and Chemotherapy |
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Efficacy of Telavancin against Penicillin-Resistant Pneumococci and Staphylococcus aureus in a Rabbit Meningitis Model and Determination of Kinetic Parameters |
| title_unstemmed |
Efficacy of Telavancin against Penicillin-Resistant Pneumococci and Staphylococcus aureus in a Rabbit Meningitis Model and Determination of Kinetic Parameters |
| title_full |
Efficacy of Telavancin against Penicillin-Resistant Pneumococci and Staphylococcus aureus in a Rabbit Meningitis Model and Determination of Kinetic Parameters |
| title_fullStr |
Efficacy of Telavancin against Penicillin-Resistant Pneumococci and Staphylococcus aureus in a Rabbit Meningitis Model and Determination of Kinetic Parameters |
| title_full_unstemmed |
Efficacy of Telavancin against Penicillin-Resistant Pneumococci and Staphylococcus aureus in a Rabbit Meningitis Model and Determination of Kinetic Parameters |
| title_short |
Efficacy of Telavancin against Penicillin-Resistant Pneumococci and Staphylococcus aureus in a Rabbit Meningitis Model and Determination of Kinetic Parameters |
| title_sort |
efficacy of telavancin against penicillin-resistant pneumococci and
<i>staphylococcus aureus</i>
in a rabbit meningitis model and determination of kinetic parameters |
| topic |
Infectious Diseases Pharmacology (medical) Pharmacology |
| url |
http://dx.doi.org/10.1128/aac.50.2.770-773.2006 |
| publishDate |
2006 |
| physical |
770-773 |
| description |
<jats:title>ABSTRACT</jats:title>
<jats:p>The penetration of telavancin was 2% into inflamed meninges and ca. 1‰ into noninflamed meninges after two intravenous injections (30 mg/kg of body weight). In experimental meningitis, telavancin was significantly superior to vancomycin combined with ceftriaxone against a penicillin-resistant pneumococcal strain. Against a methicillin-sensitive staphylococcal strain, telavancin was slightly but not significantly superior to vancomycin.</jats:p> |
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| description | <jats:title>ABSTRACT</jats:title> <jats:p>The penetration of telavancin was 2% into inflamed meninges and ca. 1‰ into noninflamed meninges after two intravenous injections (30 mg/kg of body weight). In experimental meningitis, telavancin was significantly superior to vancomycin combined with ceftriaxone against a penicillin-resistant pneumococcal strain. Against a methicillin-sensitive staphylococcal strain, telavancin was slightly but not significantly superior to vancomycin.</jats:p> |
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| spelling | Stucki, Armin Gerber, Peter Acosta, Fernando Cottagnoud, Marianne Cottagnoud, Philippe 0066-4804 1098-6596 American Society for Microbiology Infectious Diseases Pharmacology (medical) Pharmacology http://dx.doi.org/10.1128/aac.50.2.770-773.2006 <jats:title>ABSTRACT</jats:title> <jats:p>The penetration of telavancin was 2% into inflamed meninges and ca. 1‰ into noninflamed meninges after two intravenous injections (30 mg/kg of body weight). In experimental meningitis, telavancin was significantly superior to vancomycin combined with ceftriaxone against a penicillin-resistant pneumococcal strain. Against a methicillin-sensitive staphylococcal strain, telavancin was slightly but not significantly superior to vancomycin.</jats:p> Efficacy of Telavancin against Penicillin-Resistant Pneumococci and <i>Staphylococcus aureus</i> in a Rabbit Meningitis Model and Determination of Kinetic Parameters Antimicrobial Agents and Chemotherapy |
| spellingShingle | Stucki, Armin, Gerber, Peter, Acosta, Fernando, Cottagnoud, Marianne, Cottagnoud, Philippe, Antimicrobial Agents and Chemotherapy, Efficacy of Telavancin against Penicillin-Resistant Pneumococci and Staphylococcus aureus in a Rabbit Meningitis Model and Determination of Kinetic Parameters, Infectious Diseases, Pharmacology (medical), Pharmacology |
| title | Efficacy of Telavancin against Penicillin-Resistant Pneumococci and Staphylococcus aureus in a Rabbit Meningitis Model and Determination of Kinetic Parameters |
| title_full | Efficacy of Telavancin against Penicillin-Resistant Pneumococci and Staphylococcus aureus in a Rabbit Meningitis Model and Determination of Kinetic Parameters |
| title_fullStr | Efficacy of Telavancin against Penicillin-Resistant Pneumococci and Staphylococcus aureus in a Rabbit Meningitis Model and Determination of Kinetic Parameters |
| title_full_unstemmed | Efficacy of Telavancin against Penicillin-Resistant Pneumococci and Staphylococcus aureus in a Rabbit Meningitis Model and Determination of Kinetic Parameters |
| title_short | Efficacy of Telavancin against Penicillin-Resistant Pneumococci and Staphylococcus aureus in a Rabbit Meningitis Model and Determination of Kinetic Parameters |
| title_sort | efficacy of telavancin against penicillin-resistant pneumococci and <i>staphylococcus aureus</i> in a rabbit meningitis model and determination of kinetic parameters |
| title_unstemmed | Efficacy of Telavancin against Penicillin-Resistant Pneumococci and Staphylococcus aureus in a Rabbit Meningitis Model and Determination of Kinetic Parameters |
| topic | Infectious Diseases, Pharmacology (medical), Pharmacology |
| url | http://dx.doi.org/10.1128/aac.50.2.770-773.2006 |