Efficacy of Telavancin against Penicillin-Resistant Pneumococci and Staphylococcus aureus in a Rabbit Meningitis Model and Determination of Kinetic Parameters

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Bibliographische Detailangaben
Zeitschriftentitel:	Antimicrobial Agents and Chemotherapy
Personen und Körperschaften:	Stucki, Armin, Gerber, Peter, Acosta, Fernando, Cottagnoud, Marianne, Cottagnoud, Philippe
In:	Antimicrobial Agents and Chemotherapy, 50, 2006, 2, S. 770-773
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	American Society for Microbiology
Schlagwörter:	Infectious Diseases Pharmacology (medical) Pharmacology

Details
Zusammenfassung:	<jats:title>ABSTRACT</jats:title> <jats:p>The penetration of telavancin was 2% into inflamed meninges and ca. 1‰ into noninflamed meninges after two intravenous injections (30 mg/kg of body weight). In experimental meningitis, telavancin was significantly superior to vancomycin combined with ceftriaxone against a penicillin-resistant pneumococcal strain. Against a methicillin-sensitive staphylococcal strain, telavancin was slightly but not significantly superior to vancomycin.</jats:p>
Umfang:	770-773
ISSN:	0066-4804 1098-6596
DOI:	10.1128/aac.50.2.770-773.2006