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Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones
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| Zeitschriftentitel: | Antimicrobial Agents and Chemotherapy |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | Antimicrobial Agents and Chemotherapy, 47, 2003, 4, S. 1449-1451 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
|
| Schlagwörter: |
| author_facet |
Lunardi, Fabiane Guzela, Michel Rodrigues, Andrea T. Corrêa, Rogério Eger-Mangrich, Iriane Steindel, Mário Grisard, Edmundo C. Assreuy, Jamil Calixto, João B. Santos, Adair R. S. Lunardi, Fabiane Guzela, Michel Rodrigues, Andrea T. Corrêa, Rogério Eger-Mangrich, Iriane Steindel, Mário Grisard, Edmundo C. Assreuy, Jamil Calixto, João B. Santos, Adair R. S. |
|---|---|
| author |
Lunardi, Fabiane Guzela, Michel Rodrigues, Andrea T. Corrêa, Rogério Eger-Mangrich, Iriane Steindel, Mário Grisard, Edmundo C. Assreuy, Jamil Calixto, João B. Santos, Adair R. S. |
| spellingShingle |
Lunardi, Fabiane Guzela, Michel Rodrigues, Andrea T. Corrêa, Rogério Eger-Mangrich, Iriane Steindel, Mário Grisard, Edmundo C. Assreuy, Jamil Calixto, João B. Santos, Adair R. S. Antimicrobial Agents and Chemotherapy Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones Infectious Diseases Pharmacology (medical) Pharmacology |
| author_sort |
lunardi, fabiane |
| spelling |
Lunardi, Fabiane Guzela, Michel Rodrigues, Andrea T. Corrêa, Rogério Eger-Mangrich, Iriane Steindel, Mário Grisard, Edmundo C. Assreuy, Jamil Calixto, João B. Santos, Adair R. S. 0066-4804 1098-6596 American Society for Microbiology Infectious Diseases Pharmacology (medical) Pharmacology http://dx.doi.org/10.1128/aac.47.4.1449-1451.2003 <jats:title>ABSTRACT</jats:title><jats:p>Ten chalcones were synthesized and tested as potential leishmanicidal and trypanocidal agents. All tested compounds caused concentration-dependent inhibition of the in vitro growth of<jats:italic>Leishmania braziliensis</jats:italic>and<jats:italic>Trypanosoma cruzi</jats:italic>with no significant toxic effect towards host macrophages. Our results show that the positions of the substituents seem to be critical for their antiprotozoal activities.</jats:p> Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones Antimicrobial Agents and Chemotherapy |
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| title |
Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones |
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Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones |
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Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones |
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Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones |
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Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones |
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Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones |
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trypanocidal and leishmanicidal properties of substitution-containing chalcones |
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Infectious Diseases Pharmacology (medical) Pharmacology |
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http://dx.doi.org/10.1128/aac.47.4.1449-1451.2003 |
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1449-1451 |
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<jats:title>ABSTRACT</jats:title><jats:p>Ten chalcones were synthesized and tested as potential leishmanicidal and trypanocidal agents. All tested compounds caused concentration-dependent inhibition of the in vitro growth of<jats:italic>Leishmania braziliensis</jats:italic>and<jats:italic>Trypanosoma cruzi</jats:italic>with no significant toxic effect towards host macrophages. Our results show that the positions of the substituents seem to be critical for their antiprotozoal activities.</jats:p> |
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| author | Lunardi, Fabiane, Guzela, Michel, Rodrigues, Andrea T., Corrêa, Rogério, Eger-Mangrich, Iriane, Steindel, Mário, Grisard, Edmundo C., Assreuy, Jamil, Calixto, João B., Santos, Adair R. S. |
| author_facet | Lunardi, Fabiane, Guzela, Michel, Rodrigues, Andrea T., Corrêa, Rogério, Eger-Mangrich, Iriane, Steindel, Mário, Grisard, Edmundo C., Assreuy, Jamil, Calixto, João B., Santos, Adair R. S., Lunardi, Fabiane, Guzela, Michel, Rodrigues, Andrea T., Corrêa, Rogério, Eger-Mangrich, Iriane, Steindel, Mário, Grisard, Edmundo C., Assreuy, Jamil, Calixto, João B., Santos, Adair R. S. |
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| description | <jats:title>ABSTRACT</jats:title><jats:p>Ten chalcones were synthesized and tested as potential leishmanicidal and trypanocidal agents. All tested compounds caused concentration-dependent inhibition of the in vitro growth of<jats:italic>Leishmania braziliensis</jats:italic>and<jats:italic>Trypanosoma cruzi</jats:italic>with no significant toxic effect towards host macrophages. Our results show that the positions of the substituents seem to be critical for their antiprotozoal activities.</jats:p> |
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| spelling | Lunardi, Fabiane Guzela, Michel Rodrigues, Andrea T. Corrêa, Rogério Eger-Mangrich, Iriane Steindel, Mário Grisard, Edmundo C. Assreuy, Jamil Calixto, João B. Santos, Adair R. S. 0066-4804 1098-6596 American Society for Microbiology Infectious Diseases Pharmacology (medical) Pharmacology http://dx.doi.org/10.1128/aac.47.4.1449-1451.2003 <jats:title>ABSTRACT</jats:title><jats:p>Ten chalcones were synthesized and tested as potential leishmanicidal and trypanocidal agents. All tested compounds caused concentration-dependent inhibition of the in vitro growth of<jats:italic>Leishmania braziliensis</jats:italic>and<jats:italic>Trypanosoma cruzi</jats:italic>with no significant toxic effect towards host macrophages. Our results show that the positions of the substituents seem to be critical for their antiprotozoal activities.</jats:p> Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones Antimicrobial Agents and Chemotherapy |
| spellingShingle | Lunardi, Fabiane, Guzela, Michel, Rodrigues, Andrea T., Corrêa, Rogério, Eger-Mangrich, Iriane, Steindel, Mário, Grisard, Edmundo C., Assreuy, Jamil, Calixto, João B., Santos, Adair R. S., Antimicrobial Agents and Chemotherapy, Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones, Infectious Diseases, Pharmacology (medical), Pharmacology |
| title | Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones |
| title_full | Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones |
| title_fullStr | Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones |
| title_full_unstemmed | Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones |
| title_short | Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones |
| title_sort | trypanocidal and leishmanicidal properties of substitution-containing chalcones |
| title_unstemmed | Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones |
| topic | Infectious Diseases, Pharmacology (medical), Pharmacology |
| url | http://dx.doi.org/10.1128/aac.47.4.1449-1451.2003 |