Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones

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Bibliographische Detailangaben
Zeitschriftentitel:	Antimicrobial Agents and Chemotherapy
Personen und Körperschaften:	Lunardi, Fabiane, Guzela, Michel, Rodrigues, Andrea T., Corrêa, Rogério, Eger-Mangrich, Iriane, Steindel, Mário, Grisard, Edmundo C., Assreuy, Jamil, Calixto, João B., Santos, Adair R. S.
In:	Antimicrobial Agents and Chemotherapy, 47, 2003, 4, S. 1449-1451
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	American Society for Microbiology
Schlagwörter:	Infectious Diseases Pharmacology (medical) Pharmacology

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Zusammenfassung:	<jats:title>ABSTRACT</jats:title><jats:p>Ten chalcones were synthesized and tested as potential leishmanicidal and trypanocidal agents. All tested compounds caused concentration-dependent inhibition of the in vitro growth of<jats:italic>Leishmania braziliensis</jats:italic>and<jats:italic>Trypanosoma cruzi</jats:italic>with no significant toxic effect towards host macrophages. Our results show that the positions of the substituents seem to be critical for their antiprotozoal activities.</jats:p>
Umfang:	1449-1451
ISSN:	0066-4804 1098-6596
DOI:	10.1128/aac.47.4.1449-1451.2003