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Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae : Contribution of the FCY2 , FCY1 , and...
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| Zeitschriftentitel: | Antimicrobial Agents and Chemotherapy |
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| Personen und Körperschaften: | , , , , , , , |
| In: | Antimicrobial Agents and Chemotherapy, 51, 2007, 1, S. 369-371 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| author_facet |
Papon, Nicolas Noël, Thierry Florent, Martine Gibot-Leclerc, Stéphanie Jean, Dorothée Chastin, Christiane Villard, Jean Chapeland-Leclerc, Florence Papon, Nicolas Noël, Thierry Florent, Martine Gibot-Leclerc, Stéphanie Jean, Dorothée Chastin, Christiane Villard, Jean Chapeland-Leclerc, Florence |
|---|---|
| author |
Papon, Nicolas Noël, Thierry Florent, Martine Gibot-Leclerc, Stéphanie Jean, Dorothée Chastin, Christiane Villard, Jean Chapeland-Leclerc, Florence |
| spellingShingle |
Papon, Nicolas Noël, Thierry Florent, Martine Gibot-Leclerc, Stéphanie Jean, Dorothée Chastin, Christiane Villard, Jean Chapeland-Leclerc, Florence Antimicrobial Agents and Chemotherapy Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae : Contribution of the FCY2 , FCY1 , and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance Infectious Diseases Pharmacology (medical) Pharmacology |
| author_sort |
papon, nicolas |
| spelling |
Papon, Nicolas Noël, Thierry Florent, Martine Gibot-Leclerc, Stéphanie Jean, Dorothée Chastin, Christiane Villard, Jean Chapeland-Leclerc, Florence 0066-4804 1098-6596 American Society for Microbiology Infectious Diseases Pharmacology (medical) Pharmacology http://dx.doi.org/10.1128/aac.00824-06 <jats:title>ABSTRACT</jats:title> <jats:p> Inactivation of the <jats:italic>FCY2</jats:italic> (cytosine permease), <jats:italic>FCY1</jats:italic> (cytosine deaminase), and <jats:italic>FUR1</jats:italic> (uracil phosphoribosyltransferase) genes in <jats:italic>Candida lusitaniae</jats:italic> produced two patterns of resistance to flucytosine. Mutant <jats:italic>fur1</jats:italic> demonstrated resistance to 5-fluorouracil, whereas mutants <jats:italic>fcy1</jats:italic> and <jats:italic>fcy2</jats:italic> demonstrated fluconazole resistance in the presence of subinhibitory flucytosine concentrations. </jats:p> Molecular Mechanism of Flucytosine Resistance in <i>Candida lusitaniae</i> : Contribution of the <i>FCY2</i> , <i>FCY1</i> , and <i>FUR1</i> Genes to 5-Fluorouracil and Fluconazole Cross-Resistance Antimicrobial Agents and Chemotherapy |
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10.1128/aac.00824-06 |
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| title |
Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae : Contribution of the FCY2 , FCY1 , and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance |
| title_unstemmed |
Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae : Contribution of the FCY2 , FCY1 , and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance |
| title_full |
Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae : Contribution of the FCY2 , FCY1 , and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance |
| title_fullStr |
Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae : Contribution of the FCY2 , FCY1 , and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance |
| title_full_unstemmed |
Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae : Contribution of the FCY2 , FCY1 , and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance |
| title_short |
Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae : Contribution of the FCY2 , FCY1 , and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance |
| title_sort |
molecular mechanism of flucytosine resistance in
<i>candida lusitaniae</i>
: contribution of the
<i>fcy2</i>
,
<i>fcy1</i>
, and
<i>fur1</i>
genes to 5-fluorouracil and fluconazole cross-resistance |
| topic |
Infectious Diseases Pharmacology (medical) Pharmacology |
| url |
http://dx.doi.org/10.1128/aac.00824-06 |
| publishDate |
2007 |
| physical |
369-371 |
| description |
<jats:title>ABSTRACT</jats:title>
<jats:p>
Inactivation of the
<jats:italic>FCY2</jats:italic>
(cytosine permease),
<jats:italic>FCY1</jats:italic>
(cytosine deaminase), and
<jats:italic>FUR1</jats:italic>
(uracil phosphoribosyltransferase) genes in
<jats:italic>Candida lusitaniae</jats:italic>
produced two patterns of resistance to flucytosine. Mutant
<jats:italic>fur1</jats:italic>
demonstrated resistance to 5-fluorouracil, whereas mutants
<jats:italic>fcy1</jats:italic>
and
<jats:italic>fcy2</jats:italic>
demonstrated fluconazole resistance in the presence of subinhibitory flucytosine concentrations.
</jats:p> |
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| author | Papon, Nicolas, Noël, Thierry, Florent, Martine, Gibot-Leclerc, Stéphanie, Jean, Dorothée, Chastin, Christiane, Villard, Jean, Chapeland-Leclerc, Florence |
| author_facet | Papon, Nicolas, Noël, Thierry, Florent, Martine, Gibot-Leclerc, Stéphanie, Jean, Dorothée, Chastin, Christiane, Villard, Jean, Chapeland-Leclerc, Florence, Papon, Nicolas, Noël, Thierry, Florent, Martine, Gibot-Leclerc, Stéphanie, Jean, Dorothée, Chastin, Christiane, Villard, Jean, Chapeland-Leclerc, Florence |
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| description | <jats:title>ABSTRACT</jats:title> <jats:p> Inactivation of the <jats:italic>FCY2</jats:italic> (cytosine permease), <jats:italic>FCY1</jats:italic> (cytosine deaminase), and <jats:italic>FUR1</jats:italic> (uracil phosphoribosyltransferase) genes in <jats:italic>Candida lusitaniae</jats:italic> produced two patterns of resistance to flucytosine. Mutant <jats:italic>fur1</jats:italic> demonstrated resistance to 5-fluorouracil, whereas mutants <jats:italic>fcy1</jats:italic> and <jats:italic>fcy2</jats:italic> demonstrated fluconazole resistance in the presence of subinhibitory flucytosine concentrations. </jats:p> |
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| spelling | Papon, Nicolas Noël, Thierry Florent, Martine Gibot-Leclerc, Stéphanie Jean, Dorothée Chastin, Christiane Villard, Jean Chapeland-Leclerc, Florence 0066-4804 1098-6596 American Society for Microbiology Infectious Diseases Pharmacology (medical) Pharmacology http://dx.doi.org/10.1128/aac.00824-06 <jats:title>ABSTRACT</jats:title> <jats:p> Inactivation of the <jats:italic>FCY2</jats:italic> (cytosine permease), <jats:italic>FCY1</jats:italic> (cytosine deaminase), and <jats:italic>FUR1</jats:italic> (uracil phosphoribosyltransferase) genes in <jats:italic>Candida lusitaniae</jats:italic> produced two patterns of resistance to flucytosine. Mutant <jats:italic>fur1</jats:italic> demonstrated resistance to 5-fluorouracil, whereas mutants <jats:italic>fcy1</jats:italic> and <jats:italic>fcy2</jats:italic> demonstrated fluconazole resistance in the presence of subinhibitory flucytosine concentrations. </jats:p> Molecular Mechanism of Flucytosine Resistance in <i>Candida lusitaniae</i> : Contribution of the <i>FCY2</i> , <i>FCY1</i> , and <i>FUR1</i> Genes to 5-Fluorouracil and Fluconazole Cross-Resistance Antimicrobial Agents and Chemotherapy |
| spellingShingle | Papon, Nicolas, Noël, Thierry, Florent, Martine, Gibot-Leclerc, Stéphanie, Jean, Dorothée, Chastin, Christiane, Villard, Jean, Chapeland-Leclerc, Florence, Antimicrobial Agents and Chemotherapy, Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae : Contribution of the FCY2 , FCY1 , and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance, Infectious Diseases, Pharmacology (medical), Pharmacology |
| title | Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae : Contribution of the FCY2 , FCY1 , and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance |
| title_full | Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae : Contribution of the FCY2 , FCY1 , and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance |
| title_fullStr | Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae : Contribution of the FCY2 , FCY1 , and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance |
| title_full_unstemmed | Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae : Contribution of the FCY2 , FCY1 , and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance |
| title_short | Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae : Contribution of the FCY2 , FCY1 , and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance |
| title_sort | molecular mechanism of flucytosine resistance in <i>candida lusitaniae</i> : contribution of the <i>fcy2</i> , <i>fcy1</i> , and <i>fur1</i> genes to 5-fluorouracil and fluconazole cross-resistance |
| title_unstemmed | Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae : Contribution of the FCY2 , FCY1 , and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance |
| topic | Infectious Diseases, Pharmacology (medical), Pharmacology |
| url | http://dx.doi.org/10.1128/aac.00824-06 |