Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae : Contribution of the FCY2 , FCY1 , and...

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Bibliographische Detailangaben
Zeitschriftentitel:	Antimicrobial Agents and Chemotherapy
Personen und Körperschaften:	Papon, Nicolas, Noël, Thierry, Florent, Martine, Gibot-Leclerc, Stéphanie, Jean, Dorothée, Chastin, Christiane, Villard, Jean, Chapeland-Leclerc, Florence
In:	Antimicrobial Agents and Chemotherapy, 51, 2007, 1, S. 369-371
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	American Society for Microbiology
Schlagwörter:	Infectious Diseases Pharmacology (medical) Pharmacology

Details
Zusammenfassung:	<jats:title>ABSTRACT</jats:title> <jats:p> Inactivation of the <jats:italic>FCY2</jats:italic> (cytosine permease), <jats:italic>FCY1</jats:italic> (cytosine deaminase), and <jats:italic>FUR1</jats:italic> (uracil phosphoribosyltransferase) genes in <jats:italic>Candida lusitaniae</jats:italic> produced two patterns of resistance to flucytosine. Mutant <jats:italic>fur1</jats:italic> demonstrated resistance to 5-fluorouracil, whereas mutants <jats:italic>fcy1</jats:italic> and <jats:italic>fcy2</jats:italic> demonstrated fluconazole resistance in the presence of subinhibitory flucytosine concentrations. </jats:p>
Umfang:	369-371
ISSN:	0066-4804 1098-6596
DOI:	10.1128/aac.00824-06