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Effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs.
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| Zeitschriftentitel: | The Journal of Physiology |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | The Journal of Physiology, 251, 1975, 2, S. 271-279 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Chatterjee, I B Gupta, S D Majumder, A K Nandi, B K Subramanian, N Chatterjee, I B Gupta, S D Majumder, A K Nandi, B K Subramanian, N |
|---|---|
| author |
Chatterjee, I B Gupta, S D Majumder, A K Nandi, B K Subramanian, N |
| spellingShingle |
Chatterjee, I B Gupta, S D Majumder, A K Nandi, B K Subramanian, N The Journal of Physiology Effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs. Physiology |
| author_sort |
chatterjee, i b |
| spelling |
Chatterjee, I B Gupta, S D Majumder, A K Nandi, B K Subramanian, N 0022-3751 1469-7793 Wiley Physiology http://dx.doi.org/10.1113/jphysiol.1975.sp011091 <jats:p>1. In guinea‐pigs fed an ascorbic‐acid‐free diet, as the ascorbic acid levels decreased the histamine levels in blood and urine rose steadily to maxima in about 10‐12 days. The elevated histamine levels persisted in the blood and urine of scorbutic guinea‐pigs and the histamine levels in lung, gastric mucosa and spleen also increased. The increased histamine content of the urine, blood and other tissues in the ascorbic‐acid‐depleted condition could be brought back to normal levels by administration of a single dose of ascorbic acid 5 mg/100 g body wt. guinea‐pig. 3. The drop in the elevated histamine level was not due to an indirect effect of ascorbic acid on histamine forming capacity, histaminase activity or histamine release.</jats:p> Effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs. The Journal of Physiology |
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| title |
Effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs. |
| title_unstemmed |
Effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs. |
| title_full |
Effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs. |
| title_fullStr |
Effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs. |
| title_full_unstemmed |
Effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs. |
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Effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs. |
| title_sort |
effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs. |
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Physiology |
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http://dx.doi.org/10.1113/jphysiol.1975.sp011091 |
| publishDate |
1975 |
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271-279 |
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<jats:p>1. In guinea‐pigs fed an ascorbic‐acid‐free diet, as the ascorbic acid levels decreased the histamine levels in blood and urine rose steadily to maxima in about 10‐12 days. The elevated histamine levels persisted in the blood and urine of scorbutic guinea‐pigs and the histamine levels in lung, gastric mucosa and spleen also increased. The increased histamine content of the urine, blood and other tissues in the ascorbic‐acid‐depleted condition could be brought back to normal levels by administration of a single dose of ascorbic acid 5 mg/100 g body wt. guinea‐pig. 3. The drop in the elevated histamine level was not due to an indirect effect of ascorbic acid on histamine forming capacity, histaminase activity or histamine release.</jats:p> |
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| author | Chatterjee, I B, Gupta, S D, Majumder, A K, Nandi, B K, Subramanian, N |
| author_facet | Chatterjee, I B, Gupta, S D, Majumder, A K, Nandi, B K, Subramanian, N, Chatterjee, I B, Gupta, S D, Majumder, A K, Nandi, B K, Subramanian, N |
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| description | <jats:p>1. In guinea‐pigs fed an ascorbic‐acid‐free diet, as the ascorbic acid levels decreased the histamine levels in blood and urine rose steadily to maxima in about 10‐12 days. The elevated histamine levels persisted in the blood and urine of scorbutic guinea‐pigs and the histamine levels in lung, gastric mucosa and spleen also increased. The increased histamine content of the urine, blood and other tissues in the ascorbic‐acid‐depleted condition could be brought back to normal levels by administration of a single dose of ascorbic acid 5 mg/100 g body wt. guinea‐pig. 3. The drop in the elevated histamine level was not due to an indirect effect of ascorbic acid on histamine forming capacity, histaminase activity or histamine release.</jats:p> |
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| physical | 271-279 |
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| spelling | Chatterjee, I B Gupta, S D Majumder, A K Nandi, B K Subramanian, N 0022-3751 1469-7793 Wiley Physiology http://dx.doi.org/10.1113/jphysiol.1975.sp011091 <jats:p>1. In guinea‐pigs fed an ascorbic‐acid‐free diet, as the ascorbic acid levels decreased the histamine levels in blood and urine rose steadily to maxima in about 10‐12 days. The elevated histamine levels persisted in the blood and urine of scorbutic guinea‐pigs and the histamine levels in lung, gastric mucosa and spleen also increased. The increased histamine content of the urine, blood and other tissues in the ascorbic‐acid‐depleted condition could be brought back to normal levels by administration of a single dose of ascorbic acid 5 mg/100 g body wt. guinea‐pig. 3. The drop in the elevated histamine level was not due to an indirect effect of ascorbic acid on histamine forming capacity, histaminase activity or histamine release.</jats:p> Effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs. The Journal of Physiology |
| spellingShingle | Chatterjee, I B, Gupta, S D, Majumder, A K, Nandi, B K, Subramanian, N, The Journal of Physiology, Effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs., Physiology |
| title | Effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs. |
| title_full | Effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs. |
| title_fullStr | Effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs. |
| title_full_unstemmed | Effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs. |
| title_short | Effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs. |
| title_sort | effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs. |
| title_unstemmed | Effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs. |
| topic | Physiology |
| url | http://dx.doi.org/10.1113/jphysiol.1975.sp011091 |