Effect of ascorbic acid on histamine metabolism in scorbutic guinea‐pigs.

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Bibliographische Detailangaben
Zeitschriftentitel:	The Journal of Physiology
Personen und Körperschaften:	Chatterjee, I B, Gupta, S D, Majumder, A K, Nandi, B K, Subramanian, N
In:	The Journal of Physiology, 251, 1975, 2, S. 271-279
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	Wiley
Schlagwörter:	Physiology

Details
Zusammenfassung:	<jats:p>1. In guinea‐pigs fed an ascorbic‐acid‐free diet, as the ascorbic acid levels decreased the histamine levels in blood and urine rose steadily to maxima in about 10‐12 days. The elevated histamine levels persisted in the blood and urine of scorbutic guinea‐pigs and the histamine levels in lung, gastric mucosa and spleen also increased. The increased histamine content of the urine, blood and other tissues in the ascorbic‐acid‐depleted condition could be brought back to normal levels by administration of a single dose of ascorbic acid 5 mg/100 g body wt. guinea‐pig. 3. The drop in the elevated histamine level was not due to an indirect effect of ascorbic acid on histamine forming capacity, histaminase activity or histamine release.</jats:p>
Umfang:	271-279
ISSN:	1469-7793 0022-3751
DOI:	10.1113/jphysiol.1975.sp011091