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Chronic toxicity of pyrazolones: the problem of nitrosation.
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| Zeitschriftentitel: | British Journal of Clinical Pharmacology |
|---|---|
| Personen und Körperschaften: | |
| In: | British Journal of Clinical Pharmacology, 10, 1980, S2 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Kramer, M Kramer, M |
|---|---|
| author |
Kramer, M |
| spellingShingle |
Kramer, M British Journal of Clinical Pharmacology Chronic toxicity of pyrazolones: the problem of nitrosation. Pharmacology (medical) Pharmacology |
| author_sort |
kramer, m |
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Kramer, M 0306-5251 1365-2125 Wiley Pharmacology (medical) Pharmacology http://dx.doi.org/10.1111/j.1365-2125.1980.tb01815.x <jats:p>1 During 6‐month oral toxicity studies of dipyrone in rats and dogs, there was an increase in the number of reticulocytes and Heinz bodies at the highest dose, and a slight haemosiderosis was induced. 2 Similar results were obtained after parenteral administration (intravenously and subcutaneously). 3 These studies fail to contribute to the knowledge of the mechanism of allergic reactions in man. 4 In vitro studies in conditions imitating the physiological environment, show to what extent nitrosation of dipyrone takes place. 5 Subsequent toxicological investigations with the two reaction compounds, or the nitrosation product itself, are powerful instruments to show whether the nitrosamine or nitrosamide formed is dangerous. 6 In the case of pyrazolones, only aminopyrine forms a carcinogenic nitrosamine.</jats:p> Chronic toxicity of pyrazolones: the problem of nitrosation. British Journal of Clinical Pharmacology |
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| title |
Chronic toxicity of pyrazolones: the problem of nitrosation. |
| title_unstemmed |
Chronic toxicity of pyrazolones: the problem of nitrosation. |
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Chronic toxicity of pyrazolones: the problem of nitrosation. |
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Chronic toxicity of pyrazolones: the problem of nitrosation. |
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Chronic toxicity of pyrazolones: the problem of nitrosation. |
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Chronic toxicity of pyrazolones: the problem of nitrosation. |
| title_sort |
chronic toxicity of pyrazolones: the problem of nitrosation. |
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Pharmacology (medical) Pharmacology |
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http://dx.doi.org/10.1111/j.1365-2125.1980.tb01815.x |
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1980 |
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<jats:p>1 During 6‐month oral toxicity studies of dipyrone in rats and dogs, there was an increase in the number of reticulocytes and Heinz bodies at the highest dose, and a slight haemosiderosis was induced. 2 Similar results were obtained after parenteral administration (intravenously and subcutaneously). 3 These studies fail to contribute to the knowledge of the mechanism of allergic reactions in man. 4 In vitro studies in conditions imitating the physiological environment, show to what extent nitrosation of dipyrone takes place. 5 Subsequent toxicological investigations with the two reaction compounds, or the nitrosation product itself, are powerful instruments to show whether the nitrosamine or nitrosamide formed is dangerous. 6 In the case of pyrazolones, only aminopyrine forms a carcinogenic nitrosamine.</jats:p> |
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| description | <jats:p>1 During 6‐month oral toxicity studies of dipyrone in rats and dogs, there was an increase in the number of reticulocytes and Heinz bodies at the highest dose, and a slight haemosiderosis was induced. 2 Similar results were obtained after parenteral administration (intravenously and subcutaneously). 3 These studies fail to contribute to the knowledge of the mechanism of allergic reactions in man. 4 In vitro studies in conditions imitating the physiological environment, show to what extent nitrosation of dipyrone takes place. 5 Subsequent toxicological investigations with the two reaction compounds, or the nitrosation product itself, are powerful instruments to show whether the nitrosamine or nitrosamide formed is dangerous. 6 In the case of pyrazolones, only aminopyrine forms a carcinogenic nitrosamine.</jats:p> |
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| spelling | Kramer, M 0306-5251 1365-2125 Wiley Pharmacology (medical) Pharmacology http://dx.doi.org/10.1111/j.1365-2125.1980.tb01815.x <jats:p>1 During 6‐month oral toxicity studies of dipyrone in rats and dogs, there was an increase in the number of reticulocytes and Heinz bodies at the highest dose, and a slight haemosiderosis was induced. 2 Similar results were obtained after parenteral administration (intravenously and subcutaneously). 3 These studies fail to contribute to the knowledge of the mechanism of allergic reactions in man. 4 In vitro studies in conditions imitating the physiological environment, show to what extent nitrosation of dipyrone takes place. 5 Subsequent toxicological investigations with the two reaction compounds, or the nitrosation product itself, are powerful instruments to show whether the nitrosamine or nitrosamide formed is dangerous. 6 In the case of pyrazolones, only aminopyrine forms a carcinogenic nitrosamine.</jats:p> Chronic toxicity of pyrazolones: the problem of nitrosation. British Journal of Clinical Pharmacology |
| spellingShingle | Kramer, M, British Journal of Clinical Pharmacology, Chronic toxicity of pyrazolones: the problem of nitrosation., Pharmacology (medical), Pharmacology |
| title | Chronic toxicity of pyrazolones: the problem of nitrosation. |
| title_full | Chronic toxicity of pyrazolones: the problem of nitrosation. |
| title_fullStr | Chronic toxicity of pyrazolones: the problem of nitrosation. |
| title_full_unstemmed | Chronic toxicity of pyrazolones: the problem of nitrosation. |
| title_short | Chronic toxicity of pyrazolones: the problem of nitrosation. |
| title_sort | chronic toxicity of pyrazolones: the problem of nitrosation. |
| title_unstemmed | Chronic toxicity of pyrazolones: the problem of nitrosation. |
| topic | Pharmacology (medical), Pharmacology |
| url | http://dx.doi.org/10.1111/j.1365-2125.1980.tb01815.x |