Eintrag weiter verarbeiten
Chronic toxicity of pyrazolones: the problem of nitrosation.
Gespeichert in:
| Zeitschriftentitel: | British Journal of Clinical Pharmacology |
|---|---|
| Personen und Körperschaften: | |
| In: | British Journal of Clinical Pharmacology, 10, 1980, S2 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| Zusammenfassung: | <jats:p>1 During 6‐month oral toxicity studies of dipyrone in rats and dogs, there was an increase in the number of reticulocytes and Heinz bodies at the highest dose, and a slight haemosiderosis was induced. 2 Similar results were obtained after parenteral administration (intravenously and subcutaneously). 3 These studies fail to contribute to the knowledge of the mechanism of allergic reactions in man. 4 In vitro studies in conditions imitating the physiological environment, show to what extent nitrosation of dipyrone takes place. 5 Subsequent toxicological investigations with the two reaction compounds, or the nitrosation product itself, are powerful instruments to show whether the nitrosamine or nitrosamide formed is dangerous. 6 In the case of pyrazolones, only aminopyrine forms a carcinogenic nitrosamine.</jats:p> |
|---|---|
| ISSN: |
0306-5251
1365-2125 |
| DOI: | 10.1111/j.1365-2125.1980.tb01815.x |