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Evaluation of a new rapid immunoassay for the detection of Helicobacter pylori in faeces: a prospective pilot study
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| Zeitschriftentitel: | Alimentary Pharmacology & Therapeutics |
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| Personen und Körperschaften: | , , , , , , |
| In: | Alimentary Pharmacology & Therapeutics, 21, 2005, 4, S. 485-489 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| Zusammenfassung: | <jats:title>Summary</jats:title><jats:p><jats:bold>Background</jats:bold> : Detection of <jats:italic>Helicobacter pylori</jats:italic> antigen in faeces is a valid method to diagnose <jats:italic>H. pylori</jats:italic> infection. Presently available stool tests are performed in the laboratory, and diagnostic report is delayed.</jats:p><jats:p><jats:bold>Aim</jats:bold> : To evaluate a new rapid stool test in a pre‐treatment setting and to compare it with a validated laboratory stool test.</jats:p><jats:p><jats:bold>Methods</jats:bold> : A total of 105 patients underwent gastroscopy with brush cytology, and biopsies for histology and rapid urease test, to assess <jats:italic>H. pylori</jats:italic> presence. <jats:italic>Helicobacter pylori</jats:italic>‐status was considered positive if at least two tests were positive; negative if all tests were negative; indeterminate if one test was positive and two negative. Stool specimens were tested using either a rapid immunoassay kit (ImmunoCard STAT) or a laboratory enzyme immunoassay kit (Hp StAR).</jats:p><jats:p><jats:bold>Results</jats:bold> : Sixty patients were infected with <jats:italic>H. pylori</jats:italic>, 44 non‐infected, one indeterminate. The sensitivity and specificity of ImmunoCard STAT were 85 and 93%; those of Hp StAR were 88 and 100% (not significant).</jats:p><jats:p><jats:bold>Conclusions</jats:bold> : ImmunoCard STAT seems a reliable method for detecting <jats:italic>H. pylori</jats:italic> in untreated patients. It could replace laboratory stool tests, as it is easy and can be performed quickly. These characteristics might be a breakthrough for diagnosing <jats:italic>H. pylori</jats:italic> in the doctor's office.</jats:p> |
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| Umfang: | 485-489 |
| ISSN: |
0269-2813
1365-2036 |
| DOI: | 10.1111/j.1365-2036.2005.02355.x |