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New generation analysis of thrombin generation in retinal vein thrombosis

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Zeitschriftentitel: Acta Ophthalmologica
Personen und Körperschaften: Fruschelli, M., Capozzoli, M., Scapellato, C., Calzoni, P., Puccetti, L.
In: Acta Ophthalmologica, 93, 2015, S255
Format: E-Article
Sprache: Englisch
veröffentlicht:
Wiley
Schlagwörter:
Ophthalmology
General Medicine
Details
Zusammenfassung: <jats:sec><jats:title>Purpose</jats:title><jats:p>To investigate potential mechanisms involved in retinal vein occlusion (<jats:styled-content style="fixed-case">RVO</jats:styled-content>) we evaluated thrombin generation and soluble <jats:styled-content style="fixed-case">CD</jats:styled-content>40 ligand (<jats:styled-content style="fixed-case">sCD</jats:styled-content>40L) with respect to other known thrombophilic factors.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>68 patients affected by <jats:styled-content style="fixed-case">RVO</jats:styled-content> (28 central, 40 branch) and 60 healthy controls were evaluated for endogenous thrombin potential (<jats:styled-content style="fixed-case">ETP</jats:styled-content>) by a chromogenic method and <jats:styled-content style="fixed-case">sCD</jats:styled-content>40L by <jats:styled-content style="fixed-case">ELISA</jats:styled-content> technique. Polymerase chain reaction (<jats:styled-content style="fixed-case">PCR</jats:styled-content>) was employed for genetic polymorphisms and coagulative/chromogenic methods for othe coagulation factors.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Independently of genetic polymorphisms <jats:styled-content style="fixed-case">ETP</jats:styled-content> was increased in patients with <jats:styled-content style="fixed-case">CRVO</jats:styled-content> whereas <jats:styled-content style="fixed-case">sCD</jats:styled-content>40L was higher in the whole cohort.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Our data indicate an involvement of global coagulative activation in <jats:styled-content style="fixed-case">CRVO</jats:styled-content> patients as suggested by <jats:styled-content style="fixed-case">ETP</jats:styled-content>.</jats:p></jats:sec>
ISSN: 1755-375X
1755-3768
DOI: 10.1111/j.1755-3768.2015.1496