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Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats
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| Zeitschriftentitel: | CNS Neuroscience & Therapeutics |
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| Personen und Körperschaften: | , , , , , , , , , , , , , , , |
| In: | CNS Neuroscience & Therapeutics, 26, 2020, 1, S. 55-65 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Qian, Yuan Chen, Xiao‐Xiang Wang, Wei Li, Jun‐Jun Wang, Xian‐Peng Tang, Zhi‐Wei Xu, Jiao‐Tian Lin, Hai Yang, Zhi‐Yong Li, Li‐Yan Song, Xiao‐Bin Guo, Jia‐Zhi Bian, Li‐Gong Zhou, Lei Lu, Di Deng, Xing‐Li Qian, Yuan Chen, Xiao‐Xiang Wang, Wei Li, Jun‐Jun Wang, Xian‐Peng Tang, Zhi‐Wei Xu, Jiao‐Tian Lin, Hai Yang, Zhi‐Yong Li, Li‐Yan Song, Xiao‐Bin Guo, Jia‐Zhi Bian, Li‐Gong Zhou, Lei Lu, Di Deng, Xing‐Li |
|---|---|
| author |
Qian, Yuan Chen, Xiao‐Xiang Wang, Wei Li, Jun‐Jun Wang, Xian‐Peng Tang, Zhi‐Wei Xu, Jiao‐Tian Lin, Hai Yang, Zhi‐Yong Li, Li‐Yan Song, Xiao‐Bin Guo, Jia‐Zhi Bian, Li‐Gong Zhou, Lei Lu, Di Deng, Xing‐Li |
| spellingShingle |
Qian, Yuan Chen, Xiao‐Xiang Wang, Wei Li, Jun‐Jun Wang, Xian‐Peng Tang, Zhi‐Wei Xu, Jiao‐Tian Lin, Hai Yang, Zhi‐Yong Li, Li‐Yan Song, Xiao‐Bin Guo, Jia‐Zhi Bian, Li‐Gong Zhou, Lei Lu, Di Deng, Xing‐Li CNS Neuroscience & Therapeutics Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology |
| author_sort |
qian, yuan |
| spelling |
Qian, Yuan Chen, Xiao‐Xiang Wang, Wei Li, Jun‐Jun Wang, Xian‐Peng Tang, Zhi‐Wei Xu, Jiao‐Tian Lin, Hai Yang, Zhi‐Yong Li, Li‐Yan Song, Xiao‐Bin Guo, Jia‐Zhi Bian, Li‐Gong Zhou, Lei Lu, Di Deng, Xing‐Li 1755-5930 1755-5949 Wiley Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology http://dx.doi.org/10.1111/cns.13149 <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Neural stem cells (NSCs) transplantation is considered a promising treatment for Parkinson's disease. But most NSCs are differentiated into glial cells rather than neurons, and only a few of them survive after transplantation due to the inflammatory environment.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In this study, neural stem cells (NSCs) and microglial cells both forced with the <jats:italic>Nurr1</jats:italic> gene were transplanted into the striatum of the rat model of PD. The results were evaluated through reverse transcription polymerase chain reaction (RT‐PCR), Western blot, and immunofluorescence analysis.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The behavioral abnormalities of PD rats were improved by combined transplantation of NSCs and microglia, both forced with <jats:italic>Nurr1</jats:italic>. The number of tyrosine hydroxylase+ cells in the striatum of PD rats increased, and the number of Iba1+ cells decreased compared with the other groups. Moreover, the dopamine neurons differentiated from grafted NSCs could still be detected in the striatum of PD rats after 5 months.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The results suggested that transplantation of Nurr1‐overexpressing NSCs and microglia could improve the inhospitable host brain environments, which will be a new potential strategy for the cell replacement therapy in PD.</jats:p></jats:sec> Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats CNS Neuroscience & Therapeutics |
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10.1111/cns.13149 |
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Biologie Medizin Psychologie Chemie und Pharmazie |
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Wiley, 2020 |
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| title |
Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats |
| title_unstemmed |
Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats |
| title_full |
Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats |
| title_fullStr |
Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats |
| title_full_unstemmed |
Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats |
| title_short |
Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats |
| title_sort |
transplantation of nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats |
| topic |
Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology |
| url |
http://dx.doi.org/10.1111/cns.13149 |
| publishDate |
2020 |
| physical |
55-65 |
| description |
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Neural stem cells (NSCs) transplantation is considered a promising treatment for Parkinson's disease. But most NSCs are differentiated into glial cells rather than neurons, and only a few of them survive after transplantation due to the inflammatory environment.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In this study, neural stem cells (NSCs) and microglial cells both forced with the <jats:italic>Nurr1</jats:italic> gene were transplanted into the striatum of the rat model of PD. The results were evaluated through reverse transcription polymerase chain reaction (RT‐PCR), Western blot, and immunofluorescence analysis.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The behavioral abnormalities of PD rats were improved by combined transplantation of NSCs and microglia, both forced with <jats:italic>Nurr1</jats:italic>. The number of tyrosine hydroxylase+ cells in the striatum of PD rats increased, and the number of Iba1+ cells decreased compared with the other groups. Moreover, the dopamine neurons differentiated from grafted NSCs could still be detected in the striatum of PD rats after 5 months.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The results suggested that transplantation of Nurr1‐overexpressing NSCs and microglia could improve the inhospitable host brain environments, which will be a new potential strategy for the cell replacement therapy in PD.</jats:p></jats:sec> |
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| author | Qian, Yuan, Chen, Xiao‐Xiang, Wang, Wei, Li, Jun‐Jun, Wang, Xian‐Peng, Tang, Zhi‐Wei, Xu, Jiao‐Tian, Lin, Hai, Yang, Zhi‐Yong, Li, Li‐Yan, Song, Xiao‐Bin, Guo, Jia‐Zhi, Bian, Li‐Gong, Zhou, Lei, Lu, Di, Deng, Xing‐Li |
| author_facet | Qian, Yuan, Chen, Xiao‐Xiang, Wang, Wei, Li, Jun‐Jun, Wang, Xian‐Peng, Tang, Zhi‐Wei, Xu, Jiao‐Tian, Lin, Hai, Yang, Zhi‐Yong, Li, Li‐Yan, Song, Xiao‐Bin, Guo, Jia‐Zhi, Bian, Li‐Gong, Zhou, Lei, Lu, Di, Deng, Xing‐Li, Qian, Yuan, Chen, Xiao‐Xiang, Wang, Wei, Li, Jun‐Jun, Wang, Xian‐Peng, Tang, Zhi‐Wei, Xu, Jiao‐Tian, Lin, Hai, Yang, Zhi‐Yong, Li, Li‐Yan, Song, Xiao‐Bin, Guo, Jia‐Zhi, Bian, Li‐Gong, Zhou, Lei, Lu, Di, Deng, Xing‐Li |
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| description | <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Neural stem cells (NSCs) transplantation is considered a promising treatment for Parkinson's disease. But most NSCs are differentiated into glial cells rather than neurons, and only a few of them survive after transplantation due to the inflammatory environment.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In this study, neural stem cells (NSCs) and microglial cells both forced with the <jats:italic>Nurr1</jats:italic> gene were transplanted into the striatum of the rat model of PD. The results were evaluated through reverse transcription polymerase chain reaction (RT‐PCR), Western blot, and immunofluorescence analysis.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The behavioral abnormalities of PD rats were improved by combined transplantation of NSCs and microglia, both forced with <jats:italic>Nurr1</jats:italic>. The number of tyrosine hydroxylase+ cells in the striatum of PD rats increased, and the number of Iba1+ cells decreased compared with the other groups. Moreover, the dopamine neurons differentiated from grafted NSCs could still be detected in the striatum of PD rats after 5 months.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The results suggested that transplantation of Nurr1‐overexpressing NSCs and microglia could improve the inhospitable host brain environments, which will be a new potential strategy for the cell replacement therapy in PD.</jats:p></jats:sec> |
| doi_str_mv | 10.1111/cns.13149 |
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| imprint | Wiley, 2020 |
| imprint_str_mv | Wiley, 2020 |
| institution | DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14 |
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| publisher | Wiley |
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| series | CNS Neuroscience & Therapeutics |
| source_id | 49 |
| spelling | Qian, Yuan Chen, Xiao‐Xiang Wang, Wei Li, Jun‐Jun Wang, Xian‐Peng Tang, Zhi‐Wei Xu, Jiao‐Tian Lin, Hai Yang, Zhi‐Yong Li, Li‐Yan Song, Xiao‐Bin Guo, Jia‐Zhi Bian, Li‐Gong Zhou, Lei Lu, Di Deng, Xing‐Li 1755-5930 1755-5949 Wiley Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology http://dx.doi.org/10.1111/cns.13149 <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Neural stem cells (NSCs) transplantation is considered a promising treatment for Parkinson's disease. But most NSCs are differentiated into glial cells rather than neurons, and only a few of them survive after transplantation due to the inflammatory environment.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In this study, neural stem cells (NSCs) and microglial cells both forced with the <jats:italic>Nurr1</jats:italic> gene were transplanted into the striatum of the rat model of PD. The results were evaluated through reverse transcription polymerase chain reaction (RT‐PCR), Western blot, and immunofluorescence analysis.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The behavioral abnormalities of PD rats were improved by combined transplantation of NSCs and microglia, both forced with <jats:italic>Nurr1</jats:italic>. The number of tyrosine hydroxylase+ cells in the striatum of PD rats increased, and the number of Iba1+ cells decreased compared with the other groups. Moreover, the dopamine neurons differentiated from grafted NSCs could still be detected in the striatum of PD rats after 5 months.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The results suggested that transplantation of Nurr1‐overexpressing NSCs and microglia could improve the inhospitable host brain environments, which will be a new potential strategy for the cell replacement therapy in PD.</jats:p></jats:sec> Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats CNS Neuroscience & Therapeutics |
| spellingShingle | Qian, Yuan, Chen, Xiao‐Xiang, Wang, Wei, Li, Jun‐Jun, Wang, Xian‐Peng, Tang, Zhi‐Wei, Xu, Jiao‐Tian, Lin, Hai, Yang, Zhi‐Yong, Li, Li‐Yan, Song, Xiao‐Bin, Guo, Jia‐Zhi, Bian, Li‐Gong, Zhou, Lei, Lu, Di, Deng, Xing‐Li, CNS Neuroscience & Therapeutics, Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats, Pharmacology (medical), Physiology (medical), Psychiatry and Mental health, Pharmacology |
| title | Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats |
| title_full | Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats |
| title_fullStr | Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats |
| title_full_unstemmed | Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats |
| title_short | Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats |
| title_sort | transplantation of nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats |
| title_unstemmed | Transplantation of Nurr1‐overexpressing neural stem cells and microglia for treating parkinsonian rats |
| topic | Pharmacology (medical), Physiology (medical), Psychiatry and Mental health, Pharmacology |
| url | http://dx.doi.org/10.1111/cns.13149 |