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mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory
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| Zeitschriftentitel: | Learning & Memory |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Learning & Memory, 22, 2015, 12, S. 577-583 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Cold Spring Harbor Laboratory
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| Schlagwörter: |
| author_facet |
Xiong, Hui Cassé, Frédéric Zhou, Yang Zhou, Ming Xiong, Zhi-Qi Joëls, Marian Martin, Stéphane Krugers, Harm J. Xiong, Hui Cassé, Frédéric Zhou, Yang Zhou, Ming Xiong, Zhi-Qi Joëls, Marian Martin, Stéphane Krugers, Harm J. |
|---|---|
| author |
Xiong, Hui Cassé, Frédéric Zhou, Yang Zhou, Ming Xiong, Zhi-Qi Joëls, Marian Martin, Stéphane Krugers, Harm J. |
| spellingShingle |
Xiong, Hui Cassé, Frédéric Zhou, Yang Zhou, Ming Xiong, Zhi-Qi Joëls, Marian Martin, Stéphane Krugers, Harm J. Learning & Memory mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory Cellular and Molecular Neuroscience Cognitive Neuroscience Neuropsychology and Physiological Psychology |
| author_sort |
xiong, hui |
| spelling |
Xiong, Hui Cassé, Frédéric Zhou, Yang Zhou, Ming Xiong, Zhi-Qi Joëls, Marian Martin, Stéphane Krugers, Harm J. 1549-5485 Cold Spring Harbor Laboratory Cellular and Molecular Neuroscience Cognitive Neuroscience Neuropsychology and Physiological Psychology http://dx.doi.org/10.1101/lm.039420.115 <jats:p>Glucocorticoid hormones, via activation of their receptors, promote memory consolidation, but the exact underlying mechanisms remain elusive. We examined how corticosterone regulates AMPA receptors (AMPARs), which are crucial for synaptic plasticity and memory formation. Combining a live imaging fluorescent recovery after photobleaching approach with the use of the pH-sensitive GFP-AMPAR tagging revealed that corticosterone enhances the AMPAR mobile fraction and increases synaptic trapping of AMPARs in hippocampal cells. In parallel, corticosterone-enhanced AMPAR-mediated synaptic transmission. Blocking the mammalian target of rapamycin (mTOR) pathway prevented the effects of corticosterone on both AMPAR trapping—but not on the mobile fraction—and synaptic transmission. Blocking the mTOR pathway also prevented the memory enhancing effects of corticosterone in a contextual fear-conditioning paradigm. We conclude that activation of the mTOR pathway is essential for the effects of corticosterone on synaptic trapping of AMPARs and, possibly as a consequence, fearful memory formation.</jats:p> mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory Learning & Memory |
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10.1101/lm.039420.115 |
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Cold Spring Harbor Laboratory, 2015 |
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| title |
mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory |
| title_unstemmed |
mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory |
| title_full |
mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory |
| title_fullStr |
mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory |
| title_full_unstemmed |
mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory |
| title_short |
mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory |
| title_sort |
mtor is essential for corticosteroid effects on hippocampal ampa receptor function and fear memory |
| topic |
Cellular and Molecular Neuroscience Cognitive Neuroscience Neuropsychology and Physiological Psychology |
| url |
http://dx.doi.org/10.1101/lm.039420.115 |
| publishDate |
2015 |
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577-583 |
| description |
<jats:p>Glucocorticoid hormones, via activation of their receptors, promote memory consolidation, but the exact underlying mechanisms remain elusive. We examined how corticosterone regulates AMPA receptors (AMPARs), which are crucial for synaptic plasticity and memory formation. Combining a live imaging fluorescent recovery after photobleaching approach with the use of the pH-sensitive GFP-AMPAR tagging revealed that corticosterone enhances the AMPAR mobile fraction and increases synaptic trapping of AMPARs in hippocampal cells. In parallel, corticosterone-enhanced AMPAR-mediated synaptic transmission. Blocking the mammalian target of rapamycin (mTOR) pathway prevented the effects of corticosterone on both AMPAR trapping—but not on the mobile fraction—and synaptic transmission. Blocking the mTOR pathway also prevented the memory enhancing effects of corticosterone in a contextual fear-conditioning paradigm. We conclude that activation of the mTOR pathway is essential for the effects of corticosterone on synaptic trapping of AMPARs and, possibly as a consequence, fearful memory formation.</jats:p> |
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| author | Xiong, Hui, Cassé, Frédéric, Zhou, Yang, Zhou, Ming, Xiong, Zhi-Qi, Joëls, Marian, Martin, Stéphane, Krugers, Harm J. |
| author_facet | Xiong, Hui, Cassé, Frédéric, Zhou, Yang, Zhou, Ming, Xiong, Zhi-Qi, Joëls, Marian, Martin, Stéphane, Krugers, Harm J., Xiong, Hui, Cassé, Frédéric, Zhou, Yang, Zhou, Ming, Xiong, Zhi-Qi, Joëls, Marian, Martin, Stéphane, Krugers, Harm J. |
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| description | <jats:p>Glucocorticoid hormones, via activation of their receptors, promote memory consolidation, but the exact underlying mechanisms remain elusive. We examined how corticosterone regulates AMPA receptors (AMPARs), which are crucial for synaptic plasticity and memory formation. Combining a live imaging fluorescent recovery after photobleaching approach with the use of the pH-sensitive GFP-AMPAR tagging revealed that corticosterone enhances the AMPAR mobile fraction and increases synaptic trapping of AMPARs in hippocampal cells. In parallel, corticosterone-enhanced AMPAR-mediated synaptic transmission. Blocking the mammalian target of rapamycin (mTOR) pathway prevented the effects of corticosterone on both AMPAR trapping—but not on the mobile fraction—and synaptic transmission. Blocking the mTOR pathway also prevented the memory enhancing effects of corticosterone in a contextual fear-conditioning paradigm. We conclude that activation of the mTOR pathway is essential for the effects of corticosterone on synaptic trapping of AMPARs and, possibly as a consequence, fearful memory formation.</jats:p> |
| doi_str_mv | 10.1101/lm.039420.115 |
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| imprint_str_mv | Cold Spring Harbor Laboratory, 2015 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
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| series | Learning & Memory |
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| spelling | Xiong, Hui Cassé, Frédéric Zhou, Yang Zhou, Ming Xiong, Zhi-Qi Joëls, Marian Martin, Stéphane Krugers, Harm J. 1549-5485 Cold Spring Harbor Laboratory Cellular and Molecular Neuroscience Cognitive Neuroscience Neuropsychology and Physiological Psychology http://dx.doi.org/10.1101/lm.039420.115 <jats:p>Glucocorticoid hormones, via activation of their receptors, promote memory consolidation, but the exact underlying mechanisms remain elusive. We examined how corticosterone regulates AMPA receptors (AMPARs), which are crucial for synaptic plasticity and memory formation. Combining a live imaging fluorescent recovery after photobleaching approach with the use of the pH-sensitive GFP-AMPAR tagging revealed that corticosterone enhances the AMPAR mobile fraction and increases synaptic trapping of AMPARs in hippocampal cells. In parallel, corticosterone-enhanced AMPAR-mediated synaptic transmission. Blocking the mammalian target of rapamycin (mTOR) pathway prevented the effects of corticosterone on both AMPAR trapping—but not on the mobile fraction—and synaptic transmission. Blocking the mTOR pathway also prevented the memory enhancing effects of corticosterone in a contextual fear-conditioning paradigm. We conclude that activation of the mTOR pathway is essential for the effects of corticosterone on synaptic trapping of AMPARs and, possibly as a consequence, fearful memory formation.</jats:p> mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory Learning & Memory |
| spellingShingle | Xiong, Hui, Cassé, Frédéric, Zhou, Yang, Zhou, Ming, Xiong, Zhi-Qi, Joëls, Marian, Martin, Stéphane, Krugers, Harm J., Learning & Memory, mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory, Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neuropsychology and Physiological Psychology |
| title | mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory |
| title_full | mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory |
| title_fullStr | mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory |
| title_full_unstemmed | mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory |
| title_short | mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory |
| title_sort | mtor is essential for corticosteroid effects on hippocampal ampa receptor function and fear memory |
| title_unstemmed | mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory |
| topic | Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neuropsychology and Physiological Psychology |
| url | http://dx.doi.org/10.1101/lm.039420.115 |