mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory

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Bibliographische Detailangaben
Zeitschriftentitel:	Learning & Memory
Personen und Körperschaften:	Xiong, Hui, Cassé, Frédéric, Zhou, Yang, Zhou, Ming, Xiong, Zhi-Qi, Joëls, Marian, Martin, Stéphane, Krugers, Harm J.
In:	Learning & Memory, 22, 2015, 12, S. 577-583
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	Cold Spring Harbor Laboratory
Schlagwörter:	Cellular and Molecular Neuroscience Cognitive Neuroscience Neuropsychology and Physiological Psychology

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Zusammenfassung:	<jats:p>Glucocorticoid hormones, via activation of their receptors, promote memory consolidation, but the exact underlying mechanisms remain elusive. We examined how corticosterone regulates AMPA receptors (AMPARs), which are crucial for synaptic plasticity and memory formation. Combining a live imaging fluorescent recovery after photobleaching approach with the use of the pH-sensitive GFP-AMPAR tagging revealed that corticosterone enhances the AMPAR mobile fraction and increases synaptic trapping of AMPARs in hippocampal cells. In parallel, corticosterone-enhanced AMPAR-mediated synaptic transmission. Blocking the mammalian target of rapamycin (mTOR) pathway prevented the effects of corticosterone on both AMPAR trapping—but not on the mobile fraction—and synaptic transmission. Blocking the mTOR pathway also prevented the memory enhancing effects of corticosterone in a contextual fear-conditioning paradigm. We conclude that activation of the mTOR pathway is essential for the effects of corticosterone on synaptic trapping of AMPARs and, possibly as a consequence, fearful memory formation.</jats:p>
Umfang:	577-583
ISSN:	1549-5485
DOI:	10.1101/lm.039420.115