Immune evasion via PD-1/PD-L1 on NK cells and monocyte/macrophages is more prominent in Hodgkin lymphoma than DLBCL

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Bibliographische Detailangaben
Zeitschriftentitel:	Blood
Personen und Körperschaften:	Vari, Frank, Arpon, David, Keane, Colm, Hertzberg, Mark S., Talaulikar, Dipti, Jain, Sanjiv, Cui, Qingyan, Han, Erica, Tobin, Josh, Bird, Robert, Cross, Donna, Hernandez, Annette, Gould, Clare, Birch, Simone, Gandhi, Maher K.
In:	Blood, 131, 2018, 16, S. 1809-1819
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	American Society of Hematology
Schlagwörter:	Cell Biology Hematology Immunology Biochemistry

Details
Zusammenfassung:	<jats:title>Key Points</jats:title> <jats:p>Expansion of PD-1+ CD3−CD56hiCD16-ve NK cells and PD-L1+ monocytes/macrophages is more prominent in cHL than DLBCL. PD-1 blockade reverses the immune evasion mediated by the interaction of PD-1+ NK cells and PD-L1+ monocytes/macrophages.</jats:p>
Umfang:	1809-1819
ISSN:	0006-4971 1528-0020
DOI:	10.1182/blood-2017-07-796342