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High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells
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| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | Blood, 128, 2016, 7, S. 934-947 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
|
| Schlagwörter: |
| author_facet |
Oppermann, Sina Ylanko, Jarkko Shi, Yonghong Hariharan, Santosh Oakes, Christopher C. Brauer, Patrick M. Zúñiga-Pflücker, Juan C. Leber, Brian Spaner, David E. Andrews, David W. Oppermann, Sina Ylanko, Jarkko Shi, Yonghong Hariharan, Santosh Oakes, Christopher C. Brauer, Patrick M. Zúñiga-Pflücker, Juan C. Leber, Brian Spaner, David E. Andrews, David W. |
|---|---|
| author |
Oppermann, Sina Ylanko, Jarkko Shi, Yonghong Hariharan, Santosh Oakes, Christopher C. Brauer, Patrick M. Zúñiga-Pflücker, Juan C. Leber, Brian Spaner, David E. Andrews, David W. |
| spellingShingle |
Oppermann, Sina Ylanko, Jarkko Shi, Yonghong Hariharan, Santosh Oakes, Christopher C. Brauer, Patrick M. Zúñiga-Pflücker, Juan C. Leber, Brian Spaner, David E. Andrews, David W. Blood High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells Cell Biology Hematology Immunology Biochemistry |
| author_sort |
oppermann, sina |
| spelling |
Oppermann, Sina Ylanko, Jarkko Shi, Yonghong Hariharan, Santosh Oakes, Christopher C. Brauer, Patrick M. Zúñiga-Pflücker, Juan C. Leber, Brian Spaner, David E. Andrews, David W. 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2015-12-687814 <jats:title>Key Points</jats:title> <jats:p>Patient-specific pathways of resistance to venetoclax can be identified by high-content screening of clinical samples with a KI library. Sunitinib may overcome resistance to venetoclax for many patients by downregulating the expression of Bcl-xl, Mcl-1, and A1 in CLL cells.</jats:p> High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells Blood |
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10.1182/blood-2015-12-687814 |
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American Society of Hematology, 2016 |
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American Society of Hematology, 2016 |
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| title |
High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells |
| title_unstemmed |
High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells |
| title_full |
High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells |
| title_fullStr |
High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells |
| title_full_unstemmed |
High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells |
| title_short |
High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells |
| title_sort |
high-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated cll cells |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood-2015-12-687814 |
| publishDate |
2016 |
| physical |
934-947 |
| description |
<jats:title>Key Points</jats:title>
<jats:p>Patient-specific pathways of resistance to venetoclax can be identified by high-content screening of clinical samples with a KI library. Sunitinib may overcome resistance to venetoclax for many patients by downregulating the expression of Bcl-xl, Mcl-1, and A1 in CLL cells.</jats:p> |
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| author | Oppermann, Sina, Ylanko, Jarkko, Shi, Yonghong, Hariharan, Santosh, Oakes, Christopher C., Brauer, Patrick M., Zúñiga-Pflücker, Juan C., Leber, Brian, Spaner, David E., Andrews, David W. |
| author_facet | Oppermann, Sina, Ylanko, Jarkko, Shi, Yonghong, Hariharan, Santosh, Oakes, Christopher C., Brauer, Patrick M., Zúñiga-Pflücker, Juan C., Leber, Brian, Spaner, David E., Andrews, David W., Oppermann, Sina, Ylanko, Jarkko, Shi, Yonghong, Hariharan, Santosh, Oakes, Christopher C., Brauer, Patrick M., Zúñiga-Pflücker, Juan C., Leber, Brian, Spaner, David E., Andrews, David W. |
| author_sort | oppermann, sina |
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| description | <jats:title>Key Points</jats:title> <jats:p>Patient-specific pathways of resistance to venetoclax can be identified by high-content screening of clinical samples with a KI library. Sunitinib may overcome resistance to venetoclax for many patients by downregulating the expression of Bcl-xl, Mcl-1, and A1 in CLL cells.</jats:p> |
| doi_str_mv | 10.1182/blood-2015-12-687814 |
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| physical | 934-947 |
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| spelling | Oppermann, Sina Ylanko, Jarkko Shi, Yonghong Hariharan, Santosh Oakes, Christopher C. Brauer, Patrick M. Zúñiga-Pflücker, Juan C. Leber, Brian Spaner, David E. Andrews, David W. 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2015-12-687814 <jats:title>Key Points</jats:title> <jats:p>Patient-specific pathways of resistance to venetoclax can be identified by high-content screening of clinical samples with a KI library. Sunitinib may overcome resistance to venetoclax for many patients by downregulating the expression of Bcl-xl, Mcl-1, and A1 in CLL cells.</jats:p> High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells Blood |
| spellingShingle | Oppermann, Sina, Ylanko, Jarkko, Shi, Yonghong, Hariharan, Santosh, Oakes, Christopher C., Brauer, Patrick M., Zúñiga-Pflücker, Juan C., Leber, Brian, Spaner, David E., Andrews, David W., Blood, High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells, Cell Biology, Hematology, Immunology, Biochemistry |
| title | High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells |
| title_full | High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells |
| title_fullStr | High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells |
| title_full_unstemmed | High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells |
| title_short | High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells |
| title_sort | high-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated cll cells |
| title_unstemmed | High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood-2015-12-687814 |