High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells

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Bibliographische Detailangaben
Zeitschriftentitel:	Blood
Personen und Körperschaften:	Oppermann, Sina, Ylanko, Jarkko, Shi, Yonghong, Hariharan, Santosh, Oakes, Christopher C., Brauer, Patrick M., Zúñiga-Pflücker, Juan C., Leber, Brian, Spaner, David E., Andrews, David W.
In:	Blood, 128, 2016, 7, S. 934-947
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	American Society of Hematology
Schlagwörter:	Cell Biology Hematology Immunology Biochemistry

Details
Zusammenfassung:	<jats:title>Key Points</jats:title> <jats:p>Patient-specific pathways of resistance to venetoclax can be identified by high-content screening of clinical samples with a KI library. Sunitinib may overcome resistance to venetoclax for many patients by downregulating the expression of Bcl-xl, Mcl-1, and A1 in CLL cells.</jats:p>
Umfang:	934-947
ISSN:	0006-4971 1528-0020
DOI:	10.1182/blood-2015-12-687814