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Varying responses of PML-RARA with different genetic mutations to arsenic trioxide
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| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Blood, 127, 2016, 2, S. 243-250 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
|
| Schlagwörter: |
| author_facet |
Liu, Jiangying Zhu, Hong-Hu Jiang, Hao Jiang, Qian Huang, Xiao-Jun Liu, Jiangying Zhu, Hong-Hu Jiang, Hao Jiang, Qian Huang, Xiao-Jun |
|---|---|
| author |
Liu, Jiangying Zhu, Hong-Hu Jiang, Hao Jiang, Qian Huang, Xiao-Jun |
| spellingShingle |
Liu, Jiangying Zhu, Hong-Hu Jiang, Hao Jiang, Qian Huang, Xiao-Jun Blood Varying responses of PML-RARA with different genetic mutations to arsenic trioxide Cell Biology Hematology Immunology Biochemistry |
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liu, jiangying |
| spelling |
Liu, Jiangying Zhu, Hong-Hu Jiang, Hao Jiang, Qian Huang, Xiao-Jun 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2015-04-637678 <jats:title>Key Points</jats:title> <jats:p>Different point mutations in the PML moiety of PML-RARA mediate varying responses to arsenic treatment. Increasing the concentration of arsenic trioxide or combining it with ATRA may overcome the arsenic resistance driven by the acquired point mutations.</jats:p> Varying responses of PML-RARA with different genetic mutations to arsenic trioxide Blood |
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10.1182/blood-2015-04-637678 |
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American Society of Hematology, 2016 |
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American Society of Hematology, 2016 |
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| title |
Varying responses of PML-RARA with different genetic mutations to arsenic trioxide |
| title_unstemmed |
Varying responses of PML-RARA with different genetic mutations to arsenic trioxide |
| title_full |
Varying responses of PML-RARA with different genetic mutations to arsenic trioxide |
| title_fullStr |
Varying responses of PML-RARA with different genetic mutations to arsenic trioxide |
| title_full_unstemmed |
Varying responses of PML-RARA with different genetic mutations to arsenic trioxide |
| title_short |
Varying responses of PML-RARA with different genetic mutations to arsenic trioxide |
| title_sort |
varying responses of pml-rara with different genetic mutations to arsenic trioxide |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood-2015-04-637678 |
| publishDate |
2016 |
| physical |
243-250 |
| description |
<jats:title>Key Points</jats:title>
<jats:p>Different point mutations in the PML moiety of PML-RARA mediate varying responses to arsenic treatment. Increasing the concentration of arsenic trioxide or combining it with ATRA may overcome the arsenic resistance driven by the acquired point mutations.</jats:p> |
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| author | Liu, Jiangying, Zhu, Hong-Hu, Jiang, Hao, Jiang, Qian, Huang, Xiao-Jun |
| author_facet | Liu, Jiangying, Zhu, Hong-Hu, Jiang, Hao, Jiang, Qian, Huang, Xiao-Jun, Liu, Jiangying, Zhu, Hong-Hu, Jiang, Hao, Jiang, Qian, Huang, Xiao-Jun |
| author_sort | liu, jiangying |
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| description | <jats:title>Key Points</jats:title> <jats:p>Different point mutations in the PML moiety of PML-RARA mediate varying responses to arsenic treatment. Increasing the concentration of arsenic trioxide or combining it with ATRA may overcome the arsenic resistance driven by the acquired point mutations.</jats:p> |
| doi_str_mv | 10.1182/blood-2015-04-637678 |
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| imprint | American Society of Hematology, 2016 |
| imprint_str_mv | American Society of Hematology, 2016 |
| institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1 |
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| spelling | Liu, Jiangying Zhu, Hong-Hu Jiang, Hao Jiang, Qian Huang, Xiao-Jun 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2015-04-637678 <jats:title>Key Points</jats:title> <jats:p>Different point mutations in the PML moiety of PML-RARA mediate varying responses to arsenic treatment. Increasing the concentration of arsenic trioxide or combining it with ATRA may overcome the arsenic resistance driven by the acquired point mutations.</jats:p> Varying responses of PML-RARA with different genetic mutations to arsenic trioxide Blood |
| spellingShingle | Liu, Jiangying, Zhu, Hong-Hu, Jiang, Hao, Jiang, Qian, Huang, Xiao-Jun, Blood, Varying responses of PML-RARA with different genetic mutations to arsenic trioxide, Cell Biology, Hematology, Immunology, Biochemistry |
| title | Varying responses of PML-RARA with different genetic mutations to arsenic trioxide |
| title_full | Varying responses of PML-RARA with different genetic mutations to arsenic trioxide |
| title_fullStr | Varying responses of PML-RARA with different genetic mutations to arsenic trioxide |
| title_full_unstemmed | Varying responses of PML-RARA with different genetic mutations to arsenic trioxide |
| title_short | Varying responses of PML-RARA with different genetic mutations to arsenic trioxide |
| title_sort | varying responses of pml-rara with different genetic mutations to arsenic trioxide |
| title_unstemmed | Varying responses of PML-RARA with different genetic mutations to arsenic trioxide |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood-2015-04-637678 |