Varying responses of PML-RARA with different genetic mutations to arsenic trioxide

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Bibliographische Detailangaben
Zeitschriftentitel:	Blood
Personen und Körperschaften:	Liu, Jiangying, Zhu, Hong-Hu, Jiang, Hao, Jiang, Qian, Huang, Xiao-Jun
In:	Blood, 127, 2016, 2, S. 243-250
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	American Society of Hematology
Schlagwörter:	Cell Biology Hematology Immunology Biochemistry

Details
Zusammenfassung:	<jats:title>Key Points</jats:title> <jats:p>Different point mutations in the PML moiety of PML-RARA mediate varying responses to arsenic treatment. Increasing the concentration of arsenic trioxide or combining it with ATRA may overcome the arsenic resistance driven by the acquired point mutations.</jats:p>
Umfang:	243-250
ISSN:	0006-4971 1528-0020
DOI:	10.1182/blood-2015-04-637678