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TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients
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| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , |
| In: | Blood, 124, 2014, 17, S. 2705-2712 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
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| Schlagwörter: |
| author_facet |
Bejar, Rafael Lord, Allegra Stevenson, Kristen Bar-Natan, Michal Pérez-Ladaga, Albert Zaneveld, Jacques Wang, Hui Caughey, Bennett Stojanov, Petar Getz, Gad Garcia-Manero, Guillermo Kantarjian, Hagop Chen, Rui Stone, Richard M. Neuberg, Donna Steensma, David P. Ebert, Benjamin L. Bejar, Rafael Lord, Allegra Stevenson, Kristen Bar-Natan, Michal Pérez-Ladaga, Albert Zaneveld, Jacques Wang, Hui Caughey, Bennett Stojanov, Petar Getz, Gad Garcia-Manero, Guillermo Kantarjian, Hagop Chen, Rui Stone, Richard M. Neuberg, Donna Steensma, David P. Ebert, Benjamin L. |
|---|---|
| author |
Bejar, Rafael Lord, Allegra Stevenson, Kristen Bar-Natan, Michal Pérez-Ladaga, Albert Zaneveld, Jacques Wang, Hui Caughey, Bennett Stojanov, Petar Getz, Gad Garcia-Manero, Guillermo Kantarjian, Hagop Chen, Rui Stone, Richard M. Neuberg, Donna Steensma, David P. Ebert, Benjamin L. |
| spellingShingle |
Bejar, Rafael Lord, Allegra Stevenson, Kristen Bar-Natan, Michal Pérez-Ladaga, Albert Zaneveld, Jacques Wang, Hui Caughey, Bennett Stojanov, Petar Getz, Gad Garcia-Manero, Guillermo Kantarjian, Hagop Chen, Rui Stone, Richard M. Neuberg, Donna Steensma, David P. Ebert, Benjamin L. Blood TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients Cell Biology Hematology Immunology Biochemistry |
| author_sort |
bejar, rafael |
| spelling |
Bejar, Rafael Lord, Allegra Stevenson, Kristen Bar-Natan, Michal Pérez-Ladaga, Albert Zaneveld, Jacques Wang, Hui Caughey, Bennett Stojanov, Petar Getz, Gad Garcia-Manero, Guillermo Kantarjian, Hagop Chen, Rui Stone, Richard M. Neuberg, Donna Steensma, David P. Ebert, Benjamin L. 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2014-06-582809 <jats:title>Key Points</jats:title> <jats:p>Higher abundance TET2 mutations are associated with increased response to hypomethylating agents, particularly when ASXL1 is not mutated. TP53 and PTPN11 mutations are associated with shorter overall survival after hypomethylating agent treatment, but do not predict response.</jats:p> TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients Blood |
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10.1182/blood-2014-06-582809 |
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| title |
TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients |
| title_unstemmed |
TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients |
| title_full |
TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients |
| title_fullStr |
TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients |
| title_full_unstemmed |
TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients |
| title_short |
TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients |
| title_sort |
tet2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood-2014-06-582809 |
| publishDate |
2014 |
| physical |
2705-2712 |
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<jats:title>Key Points</jats:title>
<jats:p>Higher abundance TET2 mutations are associated with increased response to hypomethylating agents, particularly when ASXL1 is not mutated. TP53 and PTPN11 mutations are associated with shorter overall survival after hypomethylating agent treatment, but do not predict response.</jats:p> |
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| author | Bejar, Rafael, Lord, Allegra, Stevenson, Kristen, Bar-Natan, Michal, Pérez-Ladaga, Albert, Zaneveld, Jacques, Wang, Hui, Caughey, Bennett, Stojanov, Petar, Getz, Gad, Garcia-Manero, Guillermo, Kantarjian, Hagop, Chen, Rui, Stone, Richard M., Neuberg, Donna, Steensma, David P., Ebert, Benjamin L. |
| author_facet | Bejar, Rafael, Lord, Allegra, Stevenson, Kristen, Bar-Natan, Michal, Pérez-Ladaga, Albert, Zaneveld, Jacques, Wang, Hui, Caughey, Bennett, Stojanov, Petar, Getz, Gad, Garcia-Manero, Guillermo, Kantarjian, Hagop, Chen, Rui, Stone, Richard M., Neuberg, Donna, Steensma, David P., Ebert, Benjamin L., Bejar, Rafael, Lord, Allegra, Stevenson, Kristen, Bar-Natan, Michal, Pérez-Ladaga, Albert, Zaneveld, Jacques, Wang, Hui, Caughey, Bennett, Stojanov, Petar, Getz, Gad, Garcia-Manero, Guillermo, Kantarjian, Hagop, Chen, Rui, Stone, Richard M., Neuberg, Donna, Steensma, David P., Ebert, Benjamin L. |
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| description | <jats:title>Key Points</jats:title> <jats:p>Higher abundance TET2 mutations are associated with increased response to hypomethylating agents, particularly when ASXL1 is not mutated. TP53 and PTPN11 mutations are associated with shorter overall survival after hypomethylating agent treatment, but do not predict response.</jats:p> |
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| spelling | Bejar, Rafael Lord, Allegra Stevenson, Kristen Bar-Natan, Michal Pérez-Ladaga, Albert Zaneveld, Jacques Wang, Hui Caughey, Bennett Stojanov, Petar Getz, Gad Garcia-Manero, Guillermo Kantarjian, Hagop Chen, Rui Stone, Richard M. Neuberg, Donna Steensma, David P. Ebert, Benjamin L. 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2014-06-582809 <jats:title>Key Points</jats:title> <jats:p>Higher abundance TET2 mutations are associated with increased response to hypomethylating agents, particularly when ASXL1 is not mutated. TP53 and PTPN11 mutations are associated with shorter overall survival after hypomethylating agent treatment, but do not predict response.</jats:p> TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients Blood |
| spellingShingle | Bejar, Rafael, Lord, Allegra, Stevenson, Kristen, Bar-Natan, Michal, Pérez-Ladaga, Albert, Zaneveld, Jacques, Wang, Hui, Caughey, Bennett, Stojanov, Petar, Getz, Gad, Garcia-Manero, Guillermo, Kantarjian, Hagop, Chen, Rui, Stone, Richard M., Neuberg, Donna, Steensma, David P., Ebert, Benjamin L., Blood, TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients, Cell Biology, Hematology, Immunology, Biochemistry |
| title | TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients |
| title_full | TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients |
| title_fullStr | TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients |
| title_full_unstemmed | TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients |
| title_short | TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients |
| title_sort | tet2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients |
| title_unstemmed | TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood-2014-06-582809 |