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TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients

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Bibliographische Detailangaben
Zeitschriftentitel: Blood
Personen und Körperschaften: Bejar, Rafael, Lord, Allegra, Stevenson, Kristen, Bar-Natan, Michal, Pérez-Ladaga, Albert, Zaneveld, Jacques, Wang, Hui, Caughey, Bennett, Stojanov, Petar, Getz, Gad, Garcia-Manero, Guillermo, Kantarjian, Hagop, Chen, Rui, Stone, Richard M., Neuberg, Donna, Steensma, David P., Ebert, Benjamin L.
In: Blood, 124, 2014, 17, S. 2705-2712
Format: E-Article
Sprache: Englisch
veröffentlicht:
American Society of Hematology
Schlagwörter:
Cell Biology
Hematology
Immunology
Biochemistry
Details
Zusammenfassung: <jats:title>Key Points</jats:title> <jats:p>Higher abundance TET2 mutations are associated with increased response to hypomethylating agents, particularly when ASXL1 is not mutated. TP53 and PTPN11 mutations are associated with shorter overall survival after hypomethylating agent treatment, but do not predict response.</jats:p>
Umfang: 2705-2712
ISSN: 1528-0020
0006-4971
DOI: 10.1182/blood-2014-06-582809