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Anti-Babesial Compounds from Berberis Vulgaris
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| Zeitschriftentitel: | Natural Product Communications |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Natural Product Communications, 2, 2007, 2, S. 1934578X0700200 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
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| Schlagwörter: |
| author_facet |
Elkhateeb, A. Yamada, K. Takahashi, K. Matsuura, H. Yamasaki, M. Maede, Y. Katakura, K. Nabeta, K. Elkhateeb, A. Yamada, K. Takahashi, K. Matsuura, H. Yamasaki, M. Maede, Y. Katakura, K. Nabeta, K. |
|---|---|
| author |
Elkhateeb, A. Yamada, K. Takahashi, K. Matsuura, H. Yamasaki, M. Maede, Y. Katakura, K. Nabeta, K. |
| spellingShingle |
Elkhateeb, A. Yamada, K. Takahashi, K. Matsuura, H. Yamasaki, M. Maede, Y. Katakura, K. Nabeta, K. Natural Product Communications Anti-Babesial Compounds from Berberis Vulgaris Complementary and alternative medicine Plant Science Drug Discovery Pharmacology General Medicine |
| author_sort |
elkhateeb, a. |
| spelling |
Elkhateeb, A. Yamada, K. Takahashi, K. Matsuura, H. Yamasaki, M. Maede, Y. Katakura, K. Nabeta, K. 1934-578X 1555-9475 SAGE Publications Complementary and alternative medicine Plant Science Drug Discovery Pharmacology General Medicine http://dx.doi.org/10.1177/1934578x0700200213 <jats:p> Extracts of nine North African medicinal plants have been evaluated for their anti-babesial properties in vitro. The extracts of Berberis vulgaris and Rosa damascena showed more than 90% inhibition of the parasite growth at a test concentration of 100 μg/mL. In addition to berberine alkaloids, we isolated nine active ingredients from B. vulgaris: E-coniferyl alcohol, (-)-simulanol, p-hydroxybenzaldehyde, 3-hydroxy-4,5-dimethoxybenzoic acid, trans-ferulic acid, syringic acid, vanillic acid, cis-ferulic acid, and syringaresinol-β-D-glucoside. These compounds are all known, but are newly reported for B. vulgaris. Among them, trans-ferulic acid showed the lowest IC<jats:sub>50</jats:sub> value (7.33 μg/mL), not much above that of the standard drug, diminazene aceturate (0.60 μg/mL). </jats:p> Anti-Babesial Compounds from <i>Berberis Vulgaris</i> Natural Product Communications |
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| title |
Anti-Babesial Compounds from Berberis Vulgaris |
| title_unstemmed |
Anti-Babesial Compounds from Berberis Vulgaris |
| title_full |
Anti-Babesial Compounds from Berberis Vulgaris |
| title_fullStr |
Anti-Babesial Compounds from Berberis Vulgaris |
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Anti-Babesial Compounds from Berberis Vulgaris |
| title_short |
Anti-Babesial Compounds from Berberis Vulgaris |
| title_sort |
anti-babesial compounds from <i>berberis vulgaris</i> |
| topic |
Complementary and alternative medicine Plant Science Drug Discovery Pharmacology General Medicine |
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http://dx.doi.org/10.1177/1934578x0700200213 |
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2007 |
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1934578X0700200 |
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<jats:p> Extracts of nine North African medicinal plants have been evaluated for their anti-babesial properties in vitro. The extracts of Berberis vulgaris and Rosa damascena showed more than 90% inhibition of the parasite growth at a test concentration of 100 μg/mL. In addition to berberine alkaloids, we isolated nine active ingredients from B. vulgaris: E-coniferyl alcohol, (-)-simulanol, p-hydroxybenzaldehyde, 3-hydroxy-4,5-dimethoxybenzoic acid, trans-ferulic acid, syringic acid, vanillic acid, cis-ferulic acid, and syringaresinol-β-D-glucoside. These compounds are all known, but are newly reported for B. vulgaris. Among them, trans-ferulic acid showed the lowest IC<jats:sub>50</jats:sub> value (7.33 μg/mL), not much above that of the standard drug, diminazene aceturate (0.60 μg/mL). </jats:p> |
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| author | Elkhateeb, A., Yamada, K., Takahashi, K., Matsuura, H., Yamasaki, M., Maede, Y., Katakura, K., Nabeta, K. |
| author_facet | Elkhateeb, A., Yamada, K., Takahashi, K., Matsuura, H., Yamasaki, M., Maede, Y., Katakura, K., Nabeta, K., Elkhateeb, A., Yamada, K., Takahashi, K., Matsuura, H., Yamasaki, M., Maede, Y., Katakura, K., Nabeta, K. |
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| description | <jats:p> Extracts of nine North African medicinal plants have been evaluated for their anti-babesial properties in vitro. The extracts of Berberis vulgaris and Rosa damascena showed more than 90% inhibition of the parasite growth at a test concentration of 100 μg/mL. In addition to berberine alkaloids, we isolated nine active ingredients from B. vulgaris: E-coniferyl alcohol, (-)-simulanol, p-hydroxybenzaldehyde, 3-hydroxy-4,5-dimethoxybenzoic acid, trans-ferulic acid, syringic acid, vanillic acid, cis-ferulic acid, and syringaresinol-β-D-glucoside. These compounds are all known, but are newly reported for B. vulgaris. Among them, trans-ferulic acid showed the lowest IC<jats:sub>50</jats:sub> value (7.33 μg/mL), not much above that of the standard drug, diminazene aceturate (0.60 μg/mL). </jats:p> |
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| spelling | Elkhateeb, A. Yamada, K. Takahashi, K. Matsuura, H. Yamasaki, M. Maede, Y. Katakura, K. Nabeta, K. 1934-578X 1555-9475 SAGE Publications Complementary and alternative medicine Plant Science Drug Discovery Pharmacology General Medicine http://dx.doi.org/10.1177/1934578x0700200213 <jats:p> Extracts of nine North African medicinal plants have been evaluated for their anti-babesial properties in vitro. The extracts of Berberis vulgaris and Rosa damascena showed more than 90% inhibition of the parasite growth at a test concentration of 100 μg/mL. In addition to berberine alkaloids, we isolated nine active ingredients from B. vulgaris: E-coniferyl alcohol, (-)-simulanol, p-hydroxybenzaldehyde, 3-hydroxy-4,5-dimethoxybenzoic acid, trans-ferulic acid, syringic acid, vanillic acid, cis-ferulic acid, and syringaresinol-β-D-glucoside. These compounds are all known, but are newly reported for B. vulgaris. Among them, trans-ferulic acid showed the lowest IC<jats:sub>50</jats:sub> value (7.33 μg/mL), not much above that of the standard drug, diminazene aceturate (0.60 μg/mL). </jats:p> Anti-Babesial Compounds from <i>Berberis Vulgaris</i> Natural Product Communications |
| spellingShingle | Elkhateeb, A., Yamada, K., Takahashi, K., Matsuura, H., Yamasaki, M., Maede, Y., Katakura, K., Nabeta, K., Natural Product Communications, Anti-Babesial Compounds from Berberis Vulgaris, Complementary and alternative medicine, Plant Science, Drug Discovery, Pharmacology, General Medicine |
| title | Anti-Babesial Compounds from Berberis Vulgaris |
| title_full | Anti-Babesial Compounds from Berberis Vulgaris |
| title_fullStr | Anti-Babesial Compounds from Berberis Vulgaris |
| title_full_unstemmed | Anti-Babesial Compounds from Berberis Vulgaris |
| title_short | Anti-Babesial Compounds from Berberis Vulgaris |
| title_sort | anti-babesial compounds from <i>berberis vulgaris</i> |
| title_unstemmed | Anti-Babesial Compounds from Berberis Vulgaris |
| topic | Complementary and alternative medicine, Plant Science, Drug Discovery, Pharmacology, General Medicine |
| url | http://dx.doi.org/10.1177/1934578x0700200213 |